Absorbent paper for liquid sampling and impregnated paper calibrators and controls

• US 5,516,487 A
• Filed: 06/22/1994
• Issued: 05/14/1996
• Est. Priority Date: 06/22/1994
• Status: Expired due to Term

• Current Assignee: PerkinElmer LAS, Inc. (Perkinelmer Incorporated)
• Original Assignee: Isolab Inc.
• Inventors: Rosenthal, Murray A., Simkins, Ronald A., Greczanik, Vincent J.
• Primary Examiner(s): ALEXANDER, LYLE
• Application Number:
  US08/263,580
• Time in Patent Office: 692 Days
• Field of Search: 422/55, 422/58, 422/61, 422/99, 436/174, 73/863
• US Class Current: 422/420
• CPC Class Codes: G01N 33/521 Single-layer analytical elements
• CPC Class Codes: Y10T 436/25 including sample preparation

Abstract

The present invention is an absorbent paper piece having a plurality of samples zones adapted to receive a liquid sample. The paper comprises an absorbent paper piece having a plurality of sample zones, each sample zone having a perforation extending substantially around its perimeter, so as to substantially obstruct the capillary flow of the liquid sample from one of the sample zones having an there sample zone adjacent thereto, to the other sample zone. It is preferred that the absorbent paper piece be provided with barrier perforations interposed between adjacent sample zones, so as to provide a gap between the sample zones as an additional capillary flow barrier. The absorbent paper piece may be adapted to hold any desired sample in liquid form such as laboratory reagents, and biological samples, such as blood samples (here used to include blood, products or components of blood, and blood hemolysate). The blood or blood products may also be arrayed in a series of sample zones for purposes of control and calibration, in accordance with practices known in the art.

Claims

1. An absorbent paper piece having a plurality of sample zones adapted to receive a liquid sample, said paper piece comprising:

an absorbent paper piece having a plurality of sample zones, each said sample zone defined by a respective perimeter, and each said sample zone having a perforation, said perforation comprising a series of elongated cuts, each of said cuts block capillary flow across said gap, extending substantially around said perimeter, so as to substantially obstruct the capillary flow of said liquid sample from one of said sample zones having an other sample zone adjacent thereto, to said other sample zone.

2. An absorbent paper piece according to claim 1 wherein said absorbent paper piece comprises a pure cotton linter, white, binderless paper.

3. An absorbent paper piece according to claim 1 wherein said plurality of sample zones is divided into at least two sample zone subseries, said at least two sample zone subseries separated by a perforation so as to allow each said sample zone subseries to be separated from each other.

4. An absorbent paper piece according to claim 1 wherein said plurality of sample zones is divided into at least two sample zone subseries, said at least two sample zone subseries separated by a perforation so as to allow each said sample zone subseries to be separated from each other, and wherein each of said at least two sample zone subseries is contained on a respective sub-part of said absorbent paper piece, each said sub-part of said absorbent paper piece having sufficiently small dimensions to allow a portion of said subpart to be punched out of each its said respective sample zone subseries.

5. An absorbent paper piece according to claim 1 wherein said plurality of sample zones comprises from 2 to 100 sample zones.

6. An absorbent paper piece according to claim 5 wherein said absorbent paper piece comprises a pure cotton linter, white, binderless paper.

7. An absorbent paper piece according to claim 5 wherein said plurality of sample zones is divided into at least two sample zone subseries, said at least two sample zone subseries separated by a perforation so as to allow each said sample zone subseries to be separated from each other.

8. An absorbent paper piece according to claim 5 wherein said plurality of sample zones is divided into at least two sample zone subseries, said at least two sample zone subseries separated by a perforation so as to allow each said sample zone subseries to be separated from each other, and wherein each of said at least two sample zone subseries is contained on a respective sub-part of said absorbent paper piece, each said sub-part of said absorbent paper piece having sufficiently small dimensions to allow a portion of said sub-part to be punched out of each its said respective sample zone subseries.

9. An absorbent paper piece according to claim 1 wherein said sample zones are of a shape selected from the group consisting of circles, ovals and ovoids, and wherein said sample zone perforation comprises a series of arcuate cuts.

10. An absorbent paper piece according to claim 9 Wherein said absorbent paper piece comprises a pure cotton linter, white, binderless paper.

11. An absorbent paper piece according to claim 9 wherein said plurality of sample zones is divided into at least two sample zone subseries, said at least two sample zone subseries separated by a perforation so as to allow each said sample zone subseries to be separated from each other.

12. An absorbent paper piece according to claim 9 wherein said plurality of sample zones is divided into at least two sample zone subseries, said at least two sample zone subseries separated by a perforation so as to allow each said sample zone subseries to be separated from each other, and wherein each of said at least two sample zone subseries is contained on a respective sub-part of said absorbent paper piece, each said sub-part of said absorbent paper piece having sufficiently small dimensions to allow a portion of said sub-part to be punched out of each its said respective sample zone subseries.

13. An absorbent paper piece according to claim 1 wherein said absorbent paper additionally comprises barrier perforations interposed between adjacent sample zones.

14. An absorbent paper piece according to claim 13 wherein said absorbent paper piece comprises a pure cotton linter, white, binderless paper.

15. An absorbent paper piece according to claim 13 wherein said plurality of sample zones is divided into at least two sample zone subseries, said at least two sample zone subseries separated by a perforation so as to allow each said sample zone subseries to be separated from each other.

16. An absorbent paper piece according to claim 13 wherein said plurality of sample zones is divided into at least two sample zone subseries, said at least two sample zone subseries separated by a perforation so as to allow each said sample zone subseries to be separated from each other, and wherein each of said at least two sample zone subseries is contained on a respective sub-part of said absorbent paper piece, each said sub-part of said absorbent paper piece having sufficiently small dimensions to allow a portion of said sub-part to be punched out of each its said respective sample zone subseries.

17. An absorbent paper piece according to claim 13 wherein said barrier perforations comprise a single elongated cut.

18. An absorbent paper piece according to claim 17 wherein said absorbent paper piece comprises a pure cotton linter, white, binderless paper.

19. An absorbent paper piece according to claim 17 wherein said plurality of sample zones is divided into at least two sample zone subseries, said at least two sample zone subseries separated by a perforation so as to allow each said sample zone subseries to be separated from each other.

20. An absorbent paper piece according to either of claim 17 wherein said plurality of sample zones is divided into at least two sample zone subseries, said at least two sample zone subseries separated by a perforation so as to allow each said sample zone subseries to be separated from each other, and wherein each of said at least two sample zone subseries is contained on a respective sub-part of said absorbent paper piece, each said sub-part of said absorbent paper piece having sufficiently small dimensions to allow a portion of said sub-part to be punched out of each its said respective sample zone subseries.

21. An absorbent paper piece having a plurality of samples zones adapted to receive a blood product sample, said paper comprising:

an absorbent paper piece having a plurality of sample zones, each said sample zone defined by a respective perimeter, and each said sample zone having a perforation extending substantially around its said respective perimeter, so as to substantially obstruct the capillary flow of said blood sample from one of said sample zones having an other sample zone adjacent thereto, to said other sample zone;

at least one of said sample zones containing said blood product sample.

22. An absorbent paper piece according to claim 21 wherein said blood product sample contains sucrose.

23. An absorbent paper piece according to either of claim 22 wherein said blood sample contains sucrose present in an amount in the range of from about 0.5% to about 20% by weight of said blood product sample.