Method for treatment with dimercaptosuccinic acid (DMSA) of hypertension, diabetic neuphropathy and atherosclerosis
First Claim
1. A method for decreasing accumulation of reactive oxygen metabolites in a human or other animal, comprising administering to said human or other animal an amount of dimercapsuccinic acid effective in ameliorating hypertension-related nephrosclerosis, diabetic nephropathy, or atherosclerosis.
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Abstract
Methods for treatment of humans and other animals with dimercaptosuccinic acid (DMSA). DMSA is administered to reduce levels of silicon in blood and tissue, reduce blood pressure, improve kidney function, prevent or retard the progression of chronic renal failure, treat the accumulation of silicon in advanced kidney disease, decrease accumulation of reactive oxygen metabolites, increase superoxide dismutase activity, and/or prevent the onset or improve the current status of senile dementia or Alzheimer'"'"'s disease.
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1 Claim
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1. A method for decreasing accumulation of reactive oxygen metabolites in a human or other animal, comprising administering to said human or other animal an amount of dimercapsuccinic acid effective in ameliorating hypertension-related nephrosclerosis, diabetic nephropathy, or atherosclerosis.
Specification
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Current AssigneeCedars-Sinai Medical Center (Cedars Sinai Health System)
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Original AssigneeCedars-Sinai Medical Center (Cedars Sinai Health System)
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InventorsWeiler, Elmar W. J., Khalil-Manesh, Farhad, Gonick, Harvey C.
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Primary Examiner(s)CRIARES, THEODORE J
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Application NumberUS08/168,780Time in Patent Office888 DaysField of Search514/824, 514/578, 514/866US Class Current514/578CPC Class CodesA61K 31/19 Carboxylic acids, e.g. valp...
