Method and apparatus for progressive recruitment of cardiac fibrillation

• US 5,522,853 A
• Filed: 11/21/1994
• Issued: 06/04/1996
• Est. Priority Date: 10/27/1992
• Status: Expired due to Fees

• Current Assignee: Angeion Corporation (Niterra Co., Ltd.)
• Original Assignee: Angeion Corporation (Niterra Co., Ltd.)
• Inventors: Kroll, Mark W.
• Primary Examiner(s): Kamm, William E.
• Assistant Examiner(s): Getzow, Scott M.
• Application Number:
  US08/344,281
• Time in Patent Office: 561 Days
• Field of Search: 607/5, 607/6, 607/7, 607/8
• US Class Current: 607/5
• CPC Class Codes: A61N 1/3906 characterised by the form of the shockwave
• CPC Class Codes: A61N 1/3912 Output circuitry therefor, e.g. switches
• CPC Class Codes: A61N 1/3918 characterised by shock pathway, e.g. by electrode configuration
• CPC Class Codes: A61N 1/3956 Implantable devices for applying electric shocks to the heart, e.g. for cardioversion
• CPC Class Codes: A61N 1/3975 Power supply A61N1/378 takes precedence
• CPC Class Codes: H01M 16/00 Structural combinations of different types of electrochemical generators
• CPC Class Codes: Y02E 60/10 Energy storage using batteries

Abstract

A method and apparatus for progressive recruitment of cardiac fibrillation uses an implantable defibrillator to deliver a multiple, discontinuous pulse waveform that is comprised of a series of smaller recruitment pulses delivered prior to delivery of a larger defibrillating pulse. Instead of using multiple identical pulses to accomplish defibrillation, the present invention decreases the overall energy required for effective defibrillation with a single, larger defibrillation pulse by using multiple, smaller recruitment pulses to recruit or capture as many heart cells as possible into a primary one of the many activation wavefronts in a fibrillating heart. By synchronizing the heart cells recruited in this manner, the effectiveness of the single, larger defibrillation pulse is increased, thereby decreasing the maximum stored energy required for defibrillation.

Claims

1. An improved implantable defibrillator system for producing a multiple pulse capacitive-discharge countershock to be delivered through at least two electrodes adapted for implantation in a human patient, the implantable defibrillator system being a self-contained human implantable housing containing a waveform-generating capacitor means for storing an electrical charge, means for charging the waveform-generating capacitor means, means for sensing a cardiac dysrhythmia in the human patient, and means for selectively discharging the electrical charge in the waveform-generating capacitor means as a countershock to be delivered through the at least two electrodes in response to the means for sensing the cardiac dysrhythmia, the improvement comprising:

the means for selectively discharging including;

means for selectively discharging a plurality of recruitment pulses, each recruitment pulse spaced apart by a first time interval and delivering an electrical charge from the waveform-generating capacitor means that is less than a maximum recruitment charge; and

means for selectively discharging a defibrillation pulse spaced apart by a second time interval from the plurality of recruitment pulses and delivering an electrical charge that is greater than the maximum recruitment charge,

wherein the maximum recruitment charge is determined by an amount of electrical charge which the charging means can recharge the waveform-generating capacitor means during the second time interval.

2. The implantable defibrillator system of claim 1 wherein the means for selectively discharging the plurality of recruitment pulses includes means for delivering at least one recruitment pulse as a biphasic pulse.

3. The implantable defibrillator system of claim 1 wherein the means for selectively discharging the plurality of recruitment pulses includes means for selectively varying a discharge pathway between the at least two electrodes for successive recruitment pulses.

4. The implantable defibrillator system of claim 1 wherein the means for selectively discharging the plurality of recruitment pulses includes means for reducing a discharge voltage of the recruitment pulses in relation to a charging voltage applied to the waveform-generating capacitor means by the means for charging.

5. The implantable defibrillator system of claim 1 wherein the means for selectively discharging the plurality of recruitment pulses includes means for selectively varying the first time interval between successive recruitment pulses.

6. The implantable defibrillator system of claim 5 wherein the means for sensing includes means for sensing a fibrillation rate and wherein the means for selectively varying the first time interval between successive recruitment pulses varies the first time interval based on a percentage of the fibrillation rate.

7. The implantable defibrillator system of claim 1 wherein the means for sensing includes means for sensing a fibrillation rate and wherein the means for selectively discharging the recruitment pulses includes means for establishing the first time interval between successive recruitment pulses based on a percentage of the fibrillation rate.

8. The implantable defibrillator system of claim 1 wherein the means for selectively discharging the plurality of recruitment pulses includes means for selectively varying a polarity of the recruitment pulses.

9. The implantable defibrillator system of claim 1 wherein the means for selectively discharging limits the first and second time intervals to between 25 milliseconds and 1 second.

10. A method for operating an implantable defibrillator device electrically connected to at least two electrodes adapted for implantation in a human patient to treat cardiac dysrhythmia by delivering a multiple pulse capacitive-discharge countershock, the method comprising the device-implemented steps of:

(a) sensing for a cardiac dysrhythmia in a human patient;

(b) in response to sensing the cardiac dysrhythmia, charging a capacitive charge storage system within the implantable defibrillator device to a charge value;

(c) selectively discharging less than a first portion of the charge value stored in the capacitive charge storage system through the at least two electrodes to produce a plurality of recruitment pulses, each recruitment pulse spaced apart by a first time interval;

(d) recharging the capacitive charge storage system to the charge value after each recruitment pulse; and

(e) discharging more than the first portion of the charge value stored in the capacitive charge storage system through the at least two electrodes to produce a defibrillation pulse that is spaced apart by a second time interval from the plurality of recruitment pulses.

11. The method of claim 10 wherein the first portion of the charge value in step (c) is determined by an amount of electrical charge which step (d) can recharge the capacitive charging storage system during the second time interval.

12. The method of claim 10 wherein step (c) discharges the recruitment pulses as biphasic pulses.

13. The method of claim 10 wherein step (c) further includes the step of selectively varying a discharge pathway between the at least two electrodes for successive recruitment pulses.

14. The method of claim 10 wherein step (c) further includes the step of reducing a discharge voltage of the recruitment pulses in relation to a charging voltage applied to the capacitive charge storage system in steps (b) and (d).

15. The method of claim 10 wherein step (c) further includes the step of selectively varying the first time interval between successive recruitment pulses.

16. The method of claim 10 wherein step (a) senses a fibrillation rate and wherein step (c) further includes the step of selectively varying the first time interval between successive recruitment pulses based on a percentage of the fibrillation rate.

17. The method of claim 10 wherein step (c) further includes the step of selectively varying a polarity of the recruitment pulses.

18. The method of claim 10 wherein the first and second time intervals of step (c) and (e) are limited to between 25 milliseconds and 1 second.

19. The method of claim 10 wherein the capacitive charge storage system comprises at least two separate capacitor systems and wherein step (c) discharges less than the first portion of the charge value from a first capacitor system and step (e) discharges more than the first portion of the charge value from a second capacitor system.

20. The method of claim 19 wherein steps (b) and (d) charges the first capacitor system to a first discharge voltage and step (b) charges the second capacitor system to a second discharge voltage that is greater than the first discharge voltage.

21. An implantable defibrillator apparatus electrically connected to at least two electrodes adapted for implantation in a human patient to treat cardiac dysrhythmia by delivering a multiple pulse capacitive-discharge countershock, the implantable defibrillator apparatus comprising:

an implantable housing which contains;

sensing means for sensing a cardiac dysrhythmia in the human patient;

capacitor means for storing an electrical charge;

power source means for charging the capacitor means to a charging voltage; and

control means for selectively controlling the power source means and the capacitor means in response to the sensing of the cardiac dysrhythmia to deliver a multiple pulse capacitive-discharge countershock to the at least two electrodes including;

means for selectively discharging a plurality of recruitment pulses, each recruitment pulse spaced apart by a first time interval and delivering an electrical charge that is less than a maximum recruitment charge; and

means for selectively discharging a defibrillation pulse spaced apart by a second time interval from the plurality of recruitment pulses and delivering an electrical charge that is greater than the maximum recruitment charge.

22. The implantable defibrillator system of claim 21 wherein the means for selectively discharging the plurality of recruitment pulses includes means for delivering at least one recruitment pulse as a biphasic pulse.

23. The implantable defibrillator system of claim 21 wherein the means for selectively discharging the plurality of recruitment pulses includes means for selectively varying a discharge pathway between the at least two electrodes for successive recruitment pulses.

24. The implantable defibrillator system of claim 21 wherein the means for selectively discharging the plurality of recruitment pulses includes means for reducing a discharge voltage of the recruitment pulses in relation to a charging voltage applied to the waveform-generating capacitor means by the means for charging.

25. The implantable defibrillator system of claim 21 wherein the means for selectively discharging the plurality of recruitment pulses includes means for selectively varying the first time interval between successive recruitment pulses.

26. The implantable defibrillator system of claim 25 wherein the means for sensing includes means for sensing a fibrillation rate and wherein the means for selectively varying the first time interval between successive recruitment pulses varies the first time interval based on a percentage of the fibrillation rate.

27. The implantable defibrillator system of claim 21 wherein the means for sensing includes means for sensing a fibrillation rate and wherein the means for selectively discharging the recruitment pulses includes means for establishing the first time interval between successive recruitment pulses based on a percentage of the fibrillation rate.

28. The implantable defibrillator system of claim 21 wherein the means for selectively discharging the plurality of recruitment pulses includes means for selectively varying a polarity of the recruitment pulses.

29. The implantable defibrillator system of claim 21 wherein the means for selectively discharging limits the first and second time intervals to between 25 milliseconds and 1 second.

30. The implantable defibrillator system of claim 21 wherein the maximum recruitment charge is determined by an amount of electrical charge which the power source means can recharge the capacitor means during the longer of the second time interval.

31. The implantable defibrillator system of claim 21 wherein the capacitor means at least two separate capacitor systems and wherein the recruitment pulses are discharged from a first capacitor system and the defibrillation pulse is discharged from a second capacitor system.

32. The implantable defibrillator system of claim 31 wherein the first capacitor system is charged to a first discharge voltage and the second capacitor system is charged to a second discharge voltage that is greater than the first discharge voltage.

33. The implantable defibrillator system of claim 31 wherein the maximum recruitment charge is determined by an amount of electrical charge which the power source means can recharge the second capacitor system during shortest of the first time intervals.