Methods, primers and probes for detection of hepatitis C and novel variants

  • US 5,527,669 A
  • Filed: 05/10/1994
  • Issued: 06/18/1996
  • Est. Priority Date: 08/27/1991
  • Status: Expired due to Term
First Claim
Patent Images

1. An oligonucleotide probe for detecting the presence of Hepatitis C virus (HCV) nucleic acids, consisting of a nucleic acid sequence at least 14 nucleotides in length that hybridizes under sequence-specific, stringent hybridization conditions to a nucleotide sequence that distinguishes and is specific to an HCV strain selected from the group consisting of Japan, US, and C9 prototype, and wherein said nucleic acid sequence is contained within a sequence selected from the group consisting ofKY78 (SEQ ID NO. 18), KY81 (SEQ ID NO. 11), KY86 (SEQ ID NO. 13),KY150 (SEQ ID NO. 43), KY145 (SEQ ID NO. 19), KY83 (SEQ ID NO. 7),KY87 (SEQ ID NO. 14), KY84 (SEQ ID NO. 8), KY88 CSEO ID NO. 12),KY85 (SEQ ID NO. 9), KY100 (SEO ID NO. 21), KY148 (SEQ ID NO. 17),KY149 (SEQ ID NO. 16), KY82 (SEQ ID NO. 28), KY109 (SEO ID NO. 24),KY111(SEQ ID NO. 25), KY80 (SEQ ID NO. 5), KY144 (SEQ ID NO. 6),KY153 (SEQ ID NO. 15), SEQ ID NO. 34. SEQ ID NO. 35,SEQ ID NO. 36, SEQ ID NO. 37, SEQ ID NO. 38,SEQ ID NO. 39, SEQ ID NO. 40, SEQ ID NO. 41,SEQ ID NO. 42, and sequences complementary thereto.

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