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Reduction of skin irritation during electrotransport

  • US 5,533,971 A
  • Filed: 09/03/1993
  • Issued: 07/09/1996
  • Est. Priority Date: 09/03/1993
  • Status: Expired due to Term
First Claim
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1. In a method of operating an electrotransport delivery device which delivers an agent by electrotransport under the influence of an electric current through a skin site, the device comprising an anodic electrode assembly, a cathodic electrode assembly, a source of electrical power electrically connected to the electrode assemblies and an agent reservoir in at least one of the electrode assemblies;

  • the improvement whereby electrotransport-induced irritation of the skin site can be reduced or avoided;

    which improvement comprises;

    a) monitoring potassium concentration in the cathodic electrode assembly during electrotransport agent delivery; and

    b) reducing the electric current flowing through the skin site when the potassium concentration reaches a value which corresponds to a predetermined potassium efflux level associated with electrotransport-induced irritation of the skin.

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