System and method for providing hemodynamically optimal pacing therapy

• US 5,549,650 A
• Filed: 06/13/1994
• Issued: 08/27/1996
• Est. Priority Date: 06/13/1994
• Status: Expired due to Term

• Current Assignee: Pacesetter Incorporated (Abbott Laboratories Incorporated)
• Original Assignee: Pacesetter Incorporated (Abbott Laboratories Incorporated)
• Inventors: Moberg, Sheldon B., McClure, Kelly H., Bornzin, Gene A., Mouchawar, Gabriel
• Primary Examiner(s): Kamm, William E.
• Assistant Examiner(s): Jastrzab, Jeffrey R.
• Application Number:
  US08/259,084
• Time in Patent Office: 806 Days
• Field of Search: 607/17-19, 607/24-25, 607/9
• US Class Current: 607/24
• CPC Class Codes: A61N 1/36542 controlled by body motion, e.g. acceleration
• CPC Class Codes: A61N 1/3682 with a variable atrioventricular delay

Abstract

A system and method for a pacemaker are provided, for using cardiac wall motion sensor signals to provide hemodynamically optimal pacing therapy to patient at rest, and for providing rate-responsive pacing therapy. The cardiac wall motion sensor signals are provided by an implantable lead that incorporates an accelerometer for measuring cardiac mechanical activity. The cardiac wall motion sensor signals are processed to derive cardiac wall velocity signals and cardiac wall displacement signals. The derived signals are further processed to derive physiologic parameters indicative of cardiac performance, including stroke volume, contractility, pre-ejection period, and ejection time. The physiological parameters, in turn, are used by the pacemaker to provide hemodynamically optimal pacing therapy at rest, and rate-responsive pacing therapy.

Claims

1. A rate-responsive pacemaker for providing pacing pulses to a patient'"'"'s heart in accordance with metabolic need, the pacemaker comprising:

a cardiac wall motion sensor for providing signals representative of ventricular or cardiac wall motion;

a pulse generator for generating pacing pulses at a selectable rate;

a processor, coupled to the cardiac wall motion sensor and the pulse generator, for processing the cardiac wall motion sensor signals to derive physiologic parameters indicative of the patient'"'"'s level of metabolic need and for selecting the rate at which the pulse generator generates pacing pulses in accordance with the derived physiologic parameters.

2. The pacemaker of claim 1, wherein the processor comprises means for processing the cardiac wall motion sensor signals to derive a physiological parameter selected from the group consisting of:

stroke volume, contractility, pre-ejection period and ejection time.

3. The pacemaker of claim 2, wherein:

the cardiac wall motion sensor comprises means for measuring cardiac wall accelerations; and

the signals representative of cardiac wall motion comprise cardiac wall acceleration signals.

4. The pacemaker of claim 3, wherein the processing means for deriving stroke volume comprises:

means for twice integrating the cardiac wall acceleration signals over time to derive cardiac wall displacement signals that include a maximum displacement signal and a minimum displacement signal within a heartbeat cycle; and

means for measuring a difference between the maximum displacement signal and the minimum displacement signal, the difference being proportional to stroke volume.

5. The pacemaker of claim 4, wherein the processor comprises means for selecting the rate at which the pulse generator generates pacing pulses in accordance with the derived stroke volume.

6. The pacemaker of claim 3, wherein the processor derives contractility by:

integrating the cardiac wall acceleration signals over time to derive cardiac wall velocity signals that include a maximum velocity signal within a heartbeat cycle; and

measuring the maximum velocity signal, the measured maximum velocity signal being indicative of contractility.

7. The pacemaker of claim 6, wherein the processor selects the rate at which the pulse generator generates pacing pulses in accordance with the signal which is indicative of contractility.

8. The pacemaker of claim 3, further comprising an IEGM sensing circuit coupled to the processor, for sensing IEGM signals, wherein the processor derives pre-ejection period by:

monitoring the IEGM signals to determine a time at which an R-wave occurs within a heartbeat cycle;

integrating the cardiac wall acceleration signals over time to derive cardiac wall velocity signals that include a maximum velocity signal within the heartbeat cycle or peak acceleration;

measuring a time at which the maximum velocity signal occurs; and

measuring a time difference between the occurrence of the R-wave and the occurrence of the maximum velocity signal or peak acceleration, the time difference being representative of the pre-ejection period.

9. The pacemaker of claim 8, wherein the processor selects the rate at which the pulse generator generates pacing pulses in accordance with the measured pre-ejection period.

10. The pacemaker of claim 3, wherein the processor derives ejection time by:

integrating the cardiac wall acceleration signals over time to derive cardiac wall velocity signals that include a maximum velocity signal within a heartbeat cycle; and

measuring the time at which the maximum velocity occurs, and measuring the time at which the velocity signal is equal to zero;

determining the difference between the time at which the maximum velocity occurs and the time at which the velocity signal is equal to zero, the measured difference being representative of ejection time.

11. The pacemaker of claim 10, wherein the processor selects the rate at which the pulse generator generates pacing pulses in accordance with the measured ejection time.

12. The pacemaker of claim 10, wherein processor further processes the ejection time to derive stroke volume.

13. The pacemaker of claim 12, wherein the processor selects the rate at which the pulse generator generates pacing pulses in accordance with the derived stroke volume.

14. A pacemaker for providing hemodynamically optimal pacing therapy to a patient'"'"'s heart, the pacemaker comprising:

a cardiac wall motion sensor for generating signals representative of ventricular cardiac wall motion;

a pulse generator for generating pacing pulses in accordance with pacing parameters;

a processor, coupled to the cardiac wall motion sensor and the pulse generator, for processing the cardiac wall motion sensor signals to derive physiologic parameters indicative of cardiac performance and for optimally setting the pacing parameters in accordance with the physiologic parameters.

15. The pacemaker of claim 14, wherein the processor comprises means for processing the cardiac wall motion sensor signals to derive a physiological parameter selected from the group consisting of:

stroke volume, contractility, pre-ejection period and ejection time.

16. The pacemaker of claim 15, wherein:

the cardiac wall motion sensor comprises means for measuring cardiac wall accelerations; and

the signals representative of cardiac wall motion comprise cardiac wall acceleration signals.

17. The pacemaker of claim 16, wherein the processing means for deriving stroke volume comprises:

means for twice integrating the cardiac wall acceleration signals over time to derive cardiac wall displacement signals that include a maximum displacement signal and a minimum displacement signal within a heartbeat cycle; and

means for measuring a difference between the maximum displacement signal and the minimum displacement signal, the difference being proportional to stroke volume.

18. The pacemaker of claim 17, wherein the processor comprises means for selecting the pacing parameters in accordance with the derived stroke volume.

19. The pacemaker of claim 16, wherein the processor derives contractility by:

integrating the cardiac wall acceleration signals over time to derive cardiac wall velocity signals that include a maximum velocity signal within a heartbeat cycle; and

measuring the maximum velocity signal, the measured maximum velocity signal being indicative of contractility.

20. The pacemaker of claim 19, wherein the processor selects the pacing parameters in accordance with the signal which is indicative of contractility.

21. The pacemaker of claim 16, further comprising an IEGM sensing circuit coupled to the processor, for sensing IEGM signals, wherein the processor derives pre-ejection period by:

monitoring the IEGM signals to determine a time at which an R-wave occurs within a heartbeat cycle;

integrating the cardiac wall acceleration signals over time to derive cardiac wall velocity signals that include a maximum velocity signal within the heartbeat cycle or peak acceleration;

measuring a time at which the maximum velocity signal occurs; and

measuring a time difference between the occurrence of the R-wave and the occurrence of the maximum velocity signal or peak acceleration, the time difference being representative of the pre-ejection period.

22. The pacemaker of claim 21, wherein the processor selects the pacing parameters in accordance with the measured pre-ejection period.

23. The pacemaker of claim 16, wherein the processor derives ejection time by:

integrating the cardiac wall acceleration signals over time to derive cardiac wall velocity signals that include a maximum velocity signal within a heartbeat cycle; and

measuring the time at which the maximum velocity occurs, and measuring the time at which the velocity signal is equal to zero;

determining the difference between the time at which the maximum velocity occurs and the time at which the velocity signal is equal to zero, the measured difference being representative of ejection time.

24. The pacemaker of claim 23, wherein the processor selects the pacing parameters in accordance with the measured ejection time.

25. The pacemaker of claim 23, wherein processor further processes the ejection time to derive stroke volume.

26. The pacemaker of claim 25, wherein the processor selects the pacing parameters in accordance with the derived stroke volume.