Method and system for managing hemodynamic state and oxygen transport
First Claim
1. A method of attaining a preselected combination of MAP, SI and CI in patient comprising the steps of:
- (a) determining the patient'"'"'s mean arterial pressure (MAP), stroke index (SI) and cardiac index (CI);
(b) determining the deviation from ideal of the patient'"'"'s hemodynamic modulators intravascular volume, inotropy, chronotropy and vasoactivity using the MAP, SI and CI determined in step (a);
(c) preselecting a desired combination of MAP, SI and CI; and
(d) administering therapeutic doses of one or more pharmacologically active agents or volume expanders for altering one or more of the hemodynamic modulators to attain the preselected combination of MAP, SI and CI.
1 Assignment
0 Petitions
Accused Products
Abstract
A method of attaining a preselected systemic hemodynamic state in an patient using a per-beat basis, such as for example paired values of MAP and SI, rather than a per-minute basis, such as MAP and CI. A method of utilizing Hemodynamic Management Charts (HMCs) which permits the integration of data concerning systemic hemodynamic modulators and the systemic hemodynamic state, and which allows the identification of deviations in the levels of the hemodynamic modulators from normal levels. Also, a computer-based system which measures hemodynamic parameters and implements at least one HMC into its software, thereby permitting identification of deviations in the levels of hemodynamic modulators from normal levels. Therapeutic corrections of the deviations in hemodynamic modulator levels, such as through pharmacologically active agents or volume expanders, based on the foundation and HMCs enables the clinician to establish and maintain a patient in the normal hemodynamic state and normal perfusion state.
85 Citations
13 Claims
-
1. A method of attaining a preselected combination of MAP, SI and CI in patient comprising the steps of:
-
(a) determining the patient'"'"'s mean arterial pressure (MAP), stroke index (SI) and cardiac index (CI); (b) determining the deviation from ideal of the patient'"'"'s hemodynamic modulators intravascular volume, inotropy, chronotropy and vasoactivity using the MAP, SI and CI determined in step (a); (c) preselecting a desired combination of MAP, SI and CI; and (d) administering therapeutic doses of one or more pharmacologically active agents or volume expanders for altering one or more of the hemodynamic modulators to attain the preselected combination of MAP, SI and CI. - View Dependent Claims (2, 3, 4)
-
-
5. A method of attaining a preselected combination of MAP, SI and CI in patient comprising the steps of:
-
(a) determining the patient'"'"'s mean arterial pressure (MAP), stroke index (SI) and cardiac index (CI); (b) preselecting a desired combination of MAP, SI and CI; and (c) administering therapeutic doses of one or more pharmacologically active agents or volume expanders for altering the patient'"'"'s MAP, heart rate (HR) or SI to attain the preselected combination of MAP, SI and CI. - View Dependent Claims (6, 7, 8)
-
-
9. A method of attaining a preselected combination of MAP, SI and CI, or a preselected combination of LSWI and SSVRI in patient comprising the steps of:
-
(a) determining the patient'"'"'s mean arterial pressure (MAP), stroke index (SI) and cardiac index (CI); (b) determining the patient'"'"'s left stroke work index (LSWI) according to formula;
space="preserve" listing-type="equation">LSWI=A×
{SI×
(MAP-LAP)}and determining the patient'"'"'s stroke systemic vascular resistance index (SSVRI) according to the formula;
space="preserve" listing-type="equation">SSVRI=B×
(MAP-CVP)/SIwhere LAP represents left atrial pressure, CVP represents central venous pressure and A and B are constants; (c) determining the patient'"'"'s deviation of the combined hemodynamic modulators {volume±
inotropy}, d{V±
I}, from normovolemia/normoinotropy according to the formula;
space="preserve" listing-type="equation">d{V±
I}=+(LSWI.sub.actual /LSWI.sub.ideal -1)×
100when LSWIactual >
LSWIideal or from the formula;
space="preserve" listing-type="equation">d{V±
I}=-(LSWI.sub.ideal /LSWI.sub.actual -1)×
100when LSWIactual <
LSWIideal, where LSWIactual is the LSWI determined in step (b) and LSWIideal is known from predetermined values according to the type of patient and clinical state;(d) determining the patient'"'"'s Inotropic State Index (ISI) (e) determining the patient'"'"'s deviation in inotropy (dI) from normoinotropy using the formula;
space="preserve" listing-type="equation">dI=+(ISI.sub.ideal /ISI.sub.ideal -1)×
100when ISIactual >
ISIideal or from the formula;
space="preserve" listing-type="equation">dI=-(ISI.sub.ideal /ISI.sub.actual -1)×
100when ISIactual <
ISIideal, where ISIactual is the ISI determined in step (d) and ISIideal is known from predetermined values according to the type of patient and clinical state;(f) determining the patient'"'"'s deviation in volemia, dV, from normovolenta using the formula;
space="preserve" listing-type="equation">dV=d{V±
I}±
dI(g) determining the patient'"'"'s deviation in vasoactivity, d(Vaso), from normovasoactivity using the formula;
space="preserve" listing-type="equation">d(Vaso)=+(SSVRI.sub.actual /SSVRI.sub.ideal -1)×
100when SSVRIactual >
SSVRIideal, and from the formula;
space="preserve" listing-type="equation">d(Vaso)=-(SSVRI.sub.ideal /SSVRI.sub.actual -1)×
100when SSVRIactual <
SSVRIideal, where SSVRIactual is the SSVRI determined in step (b) and SSVRIideal is known from predetermined values according to the type of patient and clinical state;(h) determining the patient'"'"'s deviation in chronotropy (dC), from normochronotropy using the formula;
space="preserve" listing-type="equation">dC=+(CI.sub.actual /CI.sub.ideal -1)×
100when CIactual >
CIideal, and from the formula;
space="preserve" listing-type="equation">dC=-(CI.sub.ideal /CI.sub.actual -1)×
100when CIactual <
CIideal, where CIactual is the CI determined in step (a) and CIideal is known from predetermined values according to the type of patient and clinical state;(i) preselecting a desired combination of MAP, SI and CI, or a desired combination of LSWI and SSVRI; and (j) administering therapeutic doses of one or more pharmacologically active agents or volume expanders for altering one or more hemodynamic modulators to attain the preselected combination of step (i). - View Dependent Claims (10, 11, 12, 13)
-
Specification