Microminiature illuminator for administering photodynamic therapy

• US 5,571,152 A
• Filed: 05/26/1995
• Issued: 11/05/1996
• Est. Priority Date: 05/26/1995
• Status: Expired due to Fees

• Current Assignee: Light Sciences Corporation
• Original Assignee: Light Sciences Limited Partnership
• Inventors: Swanson, Brian D., Chen, James C.
• Primary Examiner(s): Sykes, Angela D.
• Assistant Examiner(s): WINAKUR, ERIC FRANK
• Application Number:
  US08/451,831
• Time in Patent Office: 529 Days
• Field of Search: 606/14, 606/15, 606/16, 606/17, 607/88, 607/89, 607/90, 607/92, 604/19, 604/20, 604/21
• US Class Current: 607/92
• CPC Class Codes: A61N 1/37205 Microstimulators, e.g. implantable through a cannula
• CPC Class Codes: A61N 2005/0651 Diodes
• CPC Class Codes: A61N 5/0601 Apparatus for use inside the body
• CPC Class Codes: A61N 5/062 Photodynamic therapy, i.e. excitation of an agent

Abstract

A plurality of microminiature light sources (10, 10'"'"') are injected at a treatment site to effect photodynamic therapy (PDT). Each of the microminiature light source beads includes an LED chip (12), a rectifier chip (14), and a plurality of electromagnetic receivers (18, 18'"'"') encapsulated within a biocompatible, light transmitting material such as silicone, forming a spherical bead that is only a few millimeters in diameter. The light source beads are sufficiently small so that they can be injected into a treatment site such as a tumor (46) from a syringe (58) through a needle (60). A photoreactive agent, which can serve as a carrier fluid for the microminiature light source beads, sensitizes the tissue at the treatment site so that light emitted by the LED chip when energized with an external electromagnetic transmitter (34) kills the tissue or other pathogens at the treatment site that have absorbed the photoreactive agent. Alternatively, a catheter (66) can be used for emplacing the microminiature light source beads at the treatment site.

Claims

1. A microminiature light source for providing light to an internal treatment site to effect a photodynamic therapy at said site, comprising:

(a) a light emitting device that produces light of a desired wavelength or waveband when energized by an electrical current, said light emitting device including a supporting substrate;

(b) a plurality of electromagnetic receivers electrically connected to the light emitting device, each one of the plurality of electromagnetic receivers comprising a core and a plurality of turns of an electrical conductor wrapped around the core, said plurality of electromagnetic receivers being thus adapted to electromagnetically couple with an external electromagnetic transmitter that produces an electromagnetic field to induce an electrical current to flow in the electromagnetic receivers, said electrical current being applied to the light emitting device to energize it; and

(c) a biocompatible, light transmitting material that encloses the light emitting device and the plurality of electromagnetic receivers to form a bead, said bead being thus adapted for insertion into the internal treatment site to effect the photodynamic therapy by providing light to the treatment site.

2. The microminiature light source of claim 1, wherein the core of each of the plurality of electromagnetic receivers comprises a half toroid.

3. The microminiature light source of claim 2, wherein each of the half toroids is oriented in a different direction relative to each other to improve the coupling with the external electromagnetic transmitter, regardless of the orientation of the bead when inserted at the treatment site.

4. The microminiature light source of claim 1, wherein the core of each of the plurality of electromagnetic receivers comprises a metallic material selected for its high magnetic permeability and low magnetic hysteresis.

5. The microminiature light source of claim 1, wherein the bead is generally spherical and less than 5 mm in diameter.

6. The microminiature light source of claim 1, wherein the light emitting device comprises a LED.

7. The microminiature light source of claim 1, further comprising a lens disposed to diffuse the light emitted by the light emitting device.

8. A system for providing light of a desired wavelength or waveband to a treatment site disposed internally within a patient'"'"'s body, to effect a photodynamic therapy of the treatment site, comprising:

(a) a light source that emits light of the desired wavelength or waveband when energized with an electrical current;

(b) an electromagnetic receiver that includes a core around which is wrapped a plurality of turns of an electrical conductor, said electrical conductor being connected to the light source;

(c) a biocompatible, light transmitting sheath enveloping the light source and the electromagnetic receiver, forming a bead sized to pass through a tube, said tube being adapted to be inserted into a patient'"'"'s body, for delivery of the bead and the light source contained therein to the treatment site;

(d) a power supply that produces an alternating current voltage; and

(e) an electromagnetic transmitter that is connected to the power supply and when energized by the power supply, is electromagnetically coupled to the electromagnetic receiver, thereby inducing an alternating current to flow in the electrical conductor wrapped around the core, said alternating current being used to energize the light source to provide light that effects the photodynamic therapy at the treatment site.

9. The system of claim 8, further comprising a rectifier that is connected to the electromagnetic receiver, said rectifier converting the alternating current to a direct current, which is supplied to energize the light source.

10. The system of claim 8, further comprising at least one other electromagnetic receiver that is connected to the light source, each of the electromagnetic receivers being oriented differently to improve electromagnetic coupling with the electromagnetic transmitter.

11. The system of claim 8, wherein the core of the electromagnetic receiver comprises a half toroid.

12. The system of claim 8, wherein the electromagnetic transmitter comprises a half-toroid core about which is wrapped a plurality of turns of an electrical conductor that is connected to the power supply.

13. The system of claim 8, further comprising an array of electromagnetic transmitters connected to the power supply, said electromagnetic transmitters being disposed at spaced-apart positions and at different orientations around the treatment site to improve electromagnetic coupling with the electromagnetic receiver.

14. The system of claim 13, wherein the electromagnetic transmitters comprising the array each include a half-toroid core, and opposite ends of the half-toroid core are oriented toward the treatment site.

15. The system of claim 8, wherein the tube comprises a needle that is connected to a syringe for injecting the bead encompassing the light source into the treatment site.

16. The system of claim 8, wherein the tube comprises a catheter having a distal end that is transcutaneously disposed at the treatment site.

17. The system of claim 8, further comprising a diffusing lens disposed within the bead, in a position overlying the light source, said diffusing lens diffusing the light emitted by the light source over the treatment site.

18. A method for providing light of a desired wavelength or waveband to an internal treatment site to effect a photodynamic therapy, comprising the steps of:

(a) providing a microminiature light source that emits light of the desired wavelength or waveband, said microminiature light source being encapsulated within a bead of a light transmissive, biocompatible material, said bead encompassing an electromagnetic receiver;

(b) injecting the bead within the internal treatment site; and

(c) energizing the light source by electromagnetically coupling power to the electromagnetic receiver from an external power source to induce an electrical current to flow in the electromagnetic receiver.

19. The method of claim 18, wherein the step of electromagnetically coupling comprises the step of coupling the external power source to an electromagnetic transmitter that is externally disposed adjacent the treatment site.

20. The method of claim 19, further comprising the step of providing a plurality of electromagnetic transmitters coupled to the external power source, each of the plurality of electromagnetic transmitters comprising a half-toroid core having opposite ends that are oriented in different directions in an array about the internal treatment site.

21. The method of claim 20, further comprising the step of periodically moving the electromagnetic transmitter to minimize exposure of a portion of a patient'"'"'s body that is disposed between the electromagnetic transmitters and the bead to an electromagnetic flux.

22. The method of claim 18, further comprising the step of providing a plurality of electromagnetic receivers within the bead, said plurality of electromagnetic receivers being disposed at different orientations within the bead to improve an efficiency of the electromagnetic coupling.

23. The method of claim 22, wherein each of the electromagnetic receivers includes a half-toroid core having opposed ends, the half-toroid core being wrapped with a plurality of turns of an electrical conductor, further comprising the step of positioning each half-toroid core so that its opposed ends face outwardly of the bead.

24. The method of claim 18, further comprising the step of diffusing the light emitted by the light source to increase an area of the treatment site receiving the light.

25. The method of claim 18, wherein the step of injecting comprises the steps of inserting a distal end of a needle that is connected to a syringe containing the bead into the treatment site, and forcing the bead from the syringe into the treatment site through the needle.

26. The method of claim 18, wherein the step of injecting comprises the steps of inserting a distal end of a catheter that is connected to a syringe containing the bead into the treatment site, and forcing the bead from the syringe into the treatment site through the catheter.

27. The method of claim 18, further comprising the step of injecting a plurality of beads into the treatment site at spaced-apart locations.

28. The method of claim 18, wherein the light source comprises an LED.

29. The method of claim 18, wherein the electrical current induced to flow in the electromagnetic receiver is an alternating current, further comprising the step of rectifying the alternating current to produce a direct current that is input to the light source to energize it.