Multilayered bioelectronic sensors
First Claim
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1. A method of forming a crystalline electrically conducting surfactant layer comprising:
- spreading over an aqueous subphase on a solid substrate a solution of surfactant comprising polymerizable surfactants capable of forming an electrically conducting surfactant polymer, wherein said aqueous subphase comprises at least one water miscible organic compound;
evaporating the solvent of said surfactant solution to produce films;
heating said substrate at a temperature and for a time sufficient to cause surfactant melting;
cooling said melted dry patches to a temperature of less than about 10°
C.; and
polymerizing said polymerizable surfactants to said electrically conducting surfactant polymer.
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Abstract
Bioelectronic sensors are provided employing a thin surfactant polymeric electrically conducting layer to which may be bound members of specific binding pairs. Binding of an analyte or a reagent to the specific binding pair member layer may change the electrical, optical, or structural properties of the layer for measurement of analyte. The change in the polymeric layer provides for a sensitive measurement.
167 Citations
8 Claims
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1. A method of forming a crystalline electrically conducting surfactant layer comprising:
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spreading over an aqueous subphase on a solid substrate a solution of surfactant comprising polymerizable surfactants capable of forming an electrically conducting surfactant polymer, wherein said aqueous subphase comprises at least one water miscible organic compound; evaporating the solvent of said surfactant solution to produce films; heating said substrate at a temperature and for a time sufficient to cause surfactant melting; cooling said melted dry patches to a temperature of less than about 10°
C.; andpolymerizing said polymerizable surfactants to said electrically conducting surfactant polymer. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8)
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Specification