Expiration collecting method and automatic expiration collector

• US 5,573,005 A
• Filed: 10/24/1994
• Issued: 11/12/1996
• Est. Priority Date: 10/25/1993
• Status: Expired due to Term

• Current Assignee: Kyoto Daiichi Kagaku Company Limited
• Original Assignee: Kyoto Daiichi Kagaku Company Limited
• Inventors: Ueda, Hideo, Yamasaki, Yutaka, Hiromoto, Mitsuo, Gang, Meng
• Primary Examiner(s): Cohen, Lee S.
• Application Number:
  US08/327,585
• Time in Patent Office: 750 Days
• Field of Search: 128/718, 128/719, 128/730, 422/84, 73/23.3
• US Class Current: 600/543
• CPC Class Codes: A61B 5/083 Measuring rate of metabolism by using breath test, e.g. measuring rate of oxygen consumption
• CPC Class Codes: G01N 1/24 Suction devices G01N1/22 - G01N1/2294 take precedence
• CPC Class Codes: G01N 2001/247 Syringes
• CPC Class Codes: G01N 33/497 of gaseous biological material, e.g. breath

Abstract

A syringe for collecting expiration is switched, to be connected by a three-way electromagnetic valve, between an expiration blowing part and a measuring part, so that expiration, blown from the expiration blowing part, is collected in the syringe while replacing old expiration. A switching valve is closed upon completion of exhalation so that end-tidal air is collected in the syringe. Thereafter the expiration sample is introduced into the measuring part from the syringe so that a constant amount of the expiration sample is collected by the measuring part to be introduced into a column.

Claims

1. An expiration collecting method, comprising the steps of:

receiving expiration from a subject into a sample collecting vessel having a volume smaller than a single expiration volume under atmospheric pressure and larger than a volume required for analysis and replacing precedently blown expiration in said sample collecting vessel by subsequently blown expiration through an expiration inlet and an expiration outlet; and

collecting a constant amount of end-tidal air of said expiration from said sample collecting vessel upon completion of a single exhalation into said sample collecting vessel and guiding said constant amount of end-tidal air of said expiration to an analyzer.

2. An expiration collecting method, according to claim 1, wherein after the expiration is guided to said analyzer, further comprising the steps of:

a) sucking air from an expiration blowing part into said sample collecting vessel;

b) discharging said sucked air from said sample collecting vessel; and

c) repeating said steps a) and b) two more times to complete a purge node.

3. An expiration collecting method, comprising the steps of:

receiving expiration from a subject into a sample collecting vessel having a volume smaller than a single expiration volume under atmospheric pressure and larger than a volume required for analysis and replacing precedently blown expiration in said sample collecting vessel by subsequently blown expiration through an expiration inlet and an expiration outlet; and

collecting a constant amount of said expiration from said sample collecting vessel after a lapse of a constant period from starting of said expiration from said subject, said constant period belonging to a rear half of a single exhalation into said sample collecting vessel, and guiding said constant amount to an analyzer.

4. An expiration collecting method according to claim 3, wherein after the expiration is guided to said analyzer, further comprising the steps of:

a) sucking air from an expiration blowing part into said sample collecting vessel;

b) discharging said sucked air from said sample collecting vessel; and

c) repeating said steps a) and b) two more times to complete a purge node.

5. An automatic expiration collector comprising:

an expiration blowing part;

a flow sensor being provided in a passage for expiration being blown from said expiration blowing part, said flow sensor for detecting flow of said expiration;

a sample collecting vessel having a variable volume, said sample collecting vessel for replacing precedently received expiration by subsequently received expiration through an expiration inlet, said expiration inlet receiving said expiration being supplied from said expiration blowing part and discharging collected end-tidal air of said expiration and said sample collecting vessel having a switchable expiration outlet for discharging received said expiration, said switchable expiration outlet connected to said flow sensor;

a measuring part being connected to a passage for said end-tidal air of said expiration moved from said sample collecting vessel, said measuring part for collecting a constant amount of said end-tidal air of said expiration and for guiding the end-tidal air of the expiration to an analyzer;

a passage switching part switchably connecting said expiration blowing part, said sample collecting vessel and said measuring part, said passage switching part for switching connection of said expiration inlet of said sample collecting vessel between said expiration blowing part and said measuring part;

a collection control part, associated with said flow sensor, said sample collecting vessel and passage switching part, said collection control part for enlarging said volume of said sample collecting vessel to a constant level smaller than a single expiration volume under atmospheric pressure and larger than a volume required for analysis after detection of said flow of said expiration made by said flow sensor in a state of connecting said expiration blowing part to said expiration inlet of said sample collecting vessel, for closing said expiration outlet of said sample collecting vessel upon detection made by said flow sensor on stopping of said flow of said expiration, for switching said passage switching part for connecting said expiration inlet of said sample collecting vessel to said measuring part, and thereafter moving said end-tidal air of said expiration collected in said sample collecting vessel to said measuring part; and

heating means for heating at least said expiration blowing part, said sample collecting vessel, said measuring part and said passage switching part to a temperature exceeding a body temperature of a subject.

6. An automatic expiration collector in accordance with claim 5, wherein

said sample collecting vessel is a syringe having said expiration inlet and said expiration outlet in its forward end portion and comprising a driving mechanism for varying the volume of said syringe,

said collection control part being adapted to vary said volume of said syringe between a) a state being provided with a small space in said forward end portion of said syringe for allowing flow of said expiration being received from said expiration inlet of said syringe toward said expiration outlet and b) a state of enlarging said constant volume through said driving mechanism.

7. An automatic expiration collector in accordance with claim 5, wherein

said sample collecting vessel is a bag having restoring force being provided with a constant capacity, whose volume is enlarged by supply of said expiration, and comprising a suction mechanism for sucking said expiration being collected in said bag through said measuring part,

said collection control part being adapted to suck said expiration sample from said bag by said suction mechanism thereby moving said expiration sample to said measuring part while reducing said volume of said bag.

8. An automatic expiration collector in accordance with claim 7, wherein

said bag is a flexible bag.

9. An automatic expiration collector in accordance with claim 7, wherein

said bag is a bellows type bag.