S-nitrosothiols as smooth muscle relaxants and therapeutic uses thereof
First Claim
1. A method of treating an individual to relax non-vascular smooth muscle which comprises treating an individual with S-nitrosothiol which transfers substantially exclusively charged nitric oxide species to relax non-vascular smooth muscle by administering a S-nitrosothiol which transfers substantially exclusively charged nitric oxide species to their site of action in said individual.
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Abstract
S-nitrosothiols exert a potent relaxant effect, mediated both by guanylate cyclase, and a cGMP-independent mechanism, upon non-vascular smooth muscle. Such types of smooth muscle include airway, gastrointestinal, bladder, uterine and corpus cavernosal. Thus, S-nitrosothiols may be used for the treatment or prevention of disorders associated with relation of smooth muscle, such as airway obstruction, and other respiratory disorders, bladder dysfunction, premature labor and impotence. Additionally, S-nitrosothiols may be used to alleviate smooth muscle contraction and spasm, and thus facilitate procedures involving diagnostic instrumentation, such as endoscopy, bronchoscopy, laparoscopy and cystoscopy. S-nitrosothiols also increase the binding affinity between hemoglobin and oxygen, and therefore, may be used to improve hemoglobin-oxygen binding, and oxygen transport to bodily tissues.
125 Citations
62 Claims
- 1. A method of treating an individual to relax non-vascular smooth muscle which comprises treating an individual with S-nitrosothiol which transfers substantially exclusively charged nitric oxide species to relax non-vascular smooth muscle by administering a S-nitrosothiol which transfers substantially exclusively charged nitric oxide species to their site of action in said individual.
- 3. A method of treating an individual to relax airway smooth muscle which comprises treating an individual with a S-nitrosothiol which transfers substantially exclusively charged nitric oxide species to relax airway smooth muscle by administering a S-nitrosothiol which transfers substantially exclusively charged nitric oxide species to their site of action in said individual.
- 8. A method of treating an individual to relax corpus cavernosum smooth muscle which comprises treating an individual with a S-nitrosothiol which transfers substantially exclusively charged nitric oxide species to relax corpus cavernosum smooth muscle by administering a S-nitrosothiol which transfers substantially exclusively charged nitric oxide species to their site of action in said individual.
- 9. A method of treating an individual to relax bladder smooth muscle which comprises treating an individual with a S-nitrosothiol which transfers substantially exclusively charged nitric oxide species to relax bladder smooth muscle by administering an S-nitrosothiol which transfers substantially exclusively charged nitric oxide species to their site of action in said individual.
- 10. A method of treating an individual to relax uterine smooth muscle which comprises treating an individual with a S-nitrosothiol which transfers substantially exclusively charged nitric oxide species to relax uterine smooth muscle by administering a S-nitrosothiol which transfers substantially exclusively charged nitric oxide species to their site of action in said individual.
- 21. A method of treating an individual to relax gastrointestinal smooth muscle which comprises treating an individual with a S-nitrosothiol which transfers substantially exclusively charged nitric oxide species to relax gastrointestinal smooth muscle by administering a S-nitrosothiol which transfers substantially exclusively charged nitric oxide species to their site of action in said individual.
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