Suppressant of corneal subepithelial clouding

• US 5,585,354 A
• Filed: 03/14/1995
• Issued: 12/17/1996
• Est. Priority Date: 04/18/1994
• Status: Expired due to Fees

• Current Assignee: Asubio Pharma Co., Ltd. (Daiichi Sankyo Company Limited)
• Original Assignee: Suntory Ltd (Kotobuki Realty Co., Ltd.)
• Inventors: Ohashi, Yuichi, Takahashi, Keizo
• Primary Examiner(s): FAY, ZOHREH A
• Application Number:
  US08/404,150
• Time in Patent Office: 644 Days
• Field of Search: 514/12, 514/912
• US Class Current: 424/85.4
• CPC Class Codes: A61K 38/217 IFN-gamma
• CPC Class Codes: A61P 27/02 Ophthalmic agents

Abstract

Suppressant of corneal subepithelial clouding, in particular, one that is capable of effective suppression of corneal subepithelial clouding which can potentially develop after superficial keratectomy with an excimer laser. The suppressant contains gamma-interferon or variants thereof as an active ingredient and it is formulated in dosage forms suitable for topical administration. In may be commonly applied as an eye drop or an ophthalmic ointment after formulation with additives such as isotonizers, buffer agents, stabilizers, antiseptics, pH modifiers and ophthalmic ointment bases.

Claims

1. Method of suppressing corneal subepithelial clouding by topical administration of an effective dose of γ

-interferon or a variant thereof.

2. Method according to claim 1 wherein γ

-interferon or a variant thereof is administered as an eye drop or an ophthalmic ointment.

3. Method according to claim 1 wherein γ

-interferon or a variant thereof is administered in a daily dose of 0.0001-0.1 mg.

4. A suppressant of corneal subepithelial clouding that contains γ

-interferon or a variant thereof as an active ingredient.

5. A suppressant of corneal subepithelial clouding according to claim 4 which is formulated as an eye drop or an ophthalmic ointment.