19-nor-vitamin D compounds

  • US 5,587,497 A
  • Filed: 05/16/1995
  • Issued: 12/24/1996
  • Est. Priority Date: 03/09/1989
  • Status: Expired due to Term
First Claim
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1. A compound having the formula ##STR10## where X1 and X2 are each selected from hydrogen, acyl, alkylsilyl and alkoxyalkyl, and where R is selected from alkyl, hydrogen, hydroxyalkyl, said hydroxyalkyl having from 4 to 5 carbon atoms, fluoroalkyl and a side chain of the formula ##STR11## wherein R1 represents hydrogen, hydroxy or O-acyl, R2 and R3 are each selected from alkyl, hydroxyalkyl and fluoroalkyl, or, when taken together represent the group --(CH2)m --where m is an integer having a value of from 2 to 5, R4 is selected from hydrogen, hydroxy, fluorine, O-acyl, alkyl, hydroxyalkyl and fluoroalkyl, R5 is selected from hydrogen, fluorine, alkyl, hydroxyalkyl and fluoroalkyl, or R4 and R5 taken together represent double-bonded oxygen, R6 and R7 are each selected from hydrogen, hydroxy, O-acyl, fluorine and alkyl, or, R6 and R7 taken together form a carbon-carbon double bond, and wherein n is an integer having a value of from 1 to 5 and wherein any of the groups -CH(CH3)-, -CH(R7)-, or -CH(R6)- at positions 20, 22 and 23, respectively, may be replaced by an oxygen atom, with the proviso that when n is 2 to 5 each R4 is independently selected from hydrogen, hydroxy, fluorine, O-acyl, alkyl, hydroxyalkyl and fluoroalkyl, and each R5 is independently selected from hydrogen, fluorine, alkyl, hydroxyalkyl and fluoroalkyl.

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