Method of preserving ophthalmic solution and compositions therefor

  • US 5,607,698 A
  • Filed: 11/14/1994
  • Issued: 03/04/1997
  • Est. Priority Date: 08/04/1988
  • Status: Expired due to Term
First Claim
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1. A method of preserving an eye wetting solution, an eye lubrication solution or an ophthalmic drug formulation comprising an ophthalmic active agent which is compatible with hydrogen peroxide, said method comprising the addition to said ophthalmic solution of(a) a source of hydrogen peroxide in sufficient amount to provide hydrogen peroxide in a trace amount from about 0.001% to about 0.01% by weight;

  • and of(b) one or more ocularly compatible hydrogen peroxide stabilizers in a sufficient amount to stabilize the resultant hydrogen peroxide;

    said resulting peroxide preserved eye wetting solution, eye lubrication solution or ophthalmic drug formulation to be directly instilled in the eye of a mammal, and having an ocularly compatible pH of between bout 5.5 and about 8.0.

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