Non-aqueous colonic purgative formulations
DCFirst Claim
1. An orally administrable composition capable of dispersal in the stomach for inducing purgation of the colon in humans consisting essentially of an effective colonic purgative amount of at least one sodium phosphate salt wherein said composition is in a non-aqueous form selected from the group consisting of tablets and gelatin capsules and wherein one or more additives selected from the group consisting of buffering agents, dispersal agents and binding agents are optionally present.
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Abstract
Orally administered colonic purgative formulations and methods of its use for effecting partial or complete purgation of the colon in mammals, the formulations consisting of non-aqueous admixtures of monobasic, dibasic and tribasic sodium phosphates administered in tablet or capsule form in concentrations of from 0.01 to 0.85 grams per kilogram body weight. Preferred embodiments include the addition of binders, dispersants and buffers which do not adversely affect osmolality or effectiveness of the purgative formulations.
48 Citations
19 Claims
- 1. An orally administrable composition capable of dispersal in the stomach for inducing purgation of the colon in humans consisting essentially of an effective colonic purgative amount of at least one sodium phosphate salt wherein said composition is in a non-aqueous form selected from the group consisting of tablets and gelatin capsules and wherein one or more additives selected from the group consisting of buffering agents, dispersal agents and binding agents are optionally present.
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9. A method of inducing purgation in the colon of humans comprising the steps of:
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(a) preparing a non-aqueous mixture consisting essentially of at least one sodium phosphate salt to form a purgative formulation; (b) forming an orally administrable, dry dosage form of said purgative formulation; (c) orally administering a pharmaceutically effective amount of said formulation to a human without dispersing said dry dosage form into water prior to administration; and (d) allowing said administered dry dosage form to induce purgation. - View Dependent Claims (10, 11, 12, 13, 14, 15, 16)
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17. A method of inducing purgation of the colon in mammals comprising the steps of:
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(a) preparing a non-aqueous admixture of approximately 72% by weight monobasic and approximately 26% by weight dibasic sodium phosphate salts to form a purgative formulation; (b) forming orally administrable tablets of said purgative formulation; (c) orally administering said tablets to said mammal at a rate of from 0.1 to 0.5 grams per kilogram body weight of dibasic sodium phosphate; and (d) allowing said administered dosage to induce purgation. - View Dependent Claims (18)
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19. An orally administrable, nonaqueous composition capable of dispersal within the stomach for inducing purgation in the colon of humans comprising an effective colonic purgative amount of approximately 70 to 73% monobasic sodium phosphate, approximately 26 to 30% dibasic sodium phosphate and approximately 1 to 4% inert additives selected from the group consisting of tablet binders, dispersants and buffering agents, wherein said composition is in a form selected from the group consisting of tablets and gelatin capsules.
Specification