Angiotensin II antagosist 1-biphenylmethylimidazole compounds and their therapeutic use
DC
First Claim
Patent Images
1. A compound of formula (I):
- ##STR24## wherein;
R1 represents an alkyl group having from 2 to 5 carbon atoms or an alkenyl group having from 3 to 5 carbon atoms;
R2 and R3 are independently selected from the group consisting of;
alkyl groups having from 1 to 4 carbon atoms;
R4 represents;
a hydrogen atom;
a methyl group;
an ethyl group;
oran alkanoyl group having from 1 to 5 carbon atoms;
R5 represents a group of formula --COOR5a or a group of formula --CONR8 R9,R5a representsa hydrogen atom,an alkyl group having from 1 to 4 carbon atoms,a benzyl group,an alkanoyloxyalkyl group, in which the alkanoyl part has from 1 to 5 carbon atoms, and the alkyl part is a methyl or ethyl group,a cycloalkanoyloxyalkyl group, in which the cycloalkanoyl part has 6 or 7 carbon atoms, and the alkyl part is a methyl or ethyl group,an alkoxycarbonyloxyalkyl group, in which the alkoxy part has from 1 to 4 carbon atoms, and the alkyl part is a methyl or ethyl group,a cycloalkoxycarbonyloxyalkyl group, in which the cycloalkoxy part has 5 or 6 carbon atoms, and the alkyl part is a methyl or ethyl group,a (5-phenyl-2-oxo-1,3-dioxolen-4-yl)methyl group, a (5-methyl-2-oxo-1,3-dioxolen-4-yl)methyl group, a (5-ethyl-2-oxo-1,3dioxolen-4-yl)methyl group or a phthalidyl group;
R8 and R9 are independently selected from the group consisting of hydrogen atoms,methyl groups, ethyl groups, methoxycarbonylmethyl groups, ethoxycarbonylmethyl groups and carboxymethyl groups;
or R8 and R9 together representa tetramethylene, pentamethylene, 1-carboxytetramethylene or 1-carboxypentamethylene group;
R6 represents a hydrogen atom,a methyl group, a methoxy group or a fluorine atom or a chlorine atom at the 6-position of the benzene ring;
R7 represents a carboxy group or a tetrazol-5-yl group at the 2-position of the benzene ring;
the benzyl ring which bears the substituents represented by R6 and R7 is at the 4-position of the benzyl group to which it is attached;
and pharmaceutically acceptable salts and esters thereof.
2 Assignments
Litigations
0 Petitions
Accused Products
Abstract
Compounds of the following formula (I) or the formula (I)p : ##STR1## wherein R1 is alkyl or alkenyl; R2 and R3 are hydrogen, alkyl, alkenyl, cycloalkyl, aralkyl, aryl, or aryl fused to cycloalkyl; R4 is hydrogen, alkyl, alkanoyl, alkenoyl, arylcarbonyl, alkoxycarbonyl, tetrahydropyranyl, tetrahydrothiopyranyl, tetrahydrothienyl, tetrahydrofuryl, a group of formula --SiRa Rb Rc, in which Ra, Rb and Rc are alkyl or aryl, alkoxymethyl, (alkoxyalkoxy)methyl, haloalkoxymethyl, aralkyl, aryl or alkanoyloxymethoxycarbonyl; R5 is carboxy or --CONR8 R9, wherein R8 and R9 hydrogens or alkyl, or R8 and R9 together form alkylene; R6 is hydrogen, alkyl, alkoxy or halogen; R7 is carboxy or tetrazol-5-yl; Rp1 is hydrogen, alkyl, cycloalkyl or alkanoyl; Rp2 is a single bond, alkylene or alkylidene; Rp3 and Rp4 are each hydrogen or alkyl; Rp6 is carboxy or tetrazol-5-yl; and Xp is oxygen or sulfur; and pharmaceutically acceptable salts and esters thereof. The compounds are AII receptor antagonists and thus have hypotensive activity and can be used for the treatment and prophylaxis of hypertension. The compounds may be prepared by reacting a biphenylmethyl compound with an imidazole compound.
162 Citations
42 Claims
-
1. A compound of formula (I):
- ##STR24## wherein;
R1 represents an alkyl group having from 2 to 5 carbon atoms or an alkenyl group having from 3 to 5 carbon atoms;R2 and R3 are independently selected from the group consisting of; alkyl groups having from 1 to 4 carbon atoms; R4 represents; a hydrogen atom;
a methyl group;
an ethyl group;
oran alkanoyl group having from 1 to 5 carbon atoms; R5 represents a group of formula --COOR5a or a group of formula --CONR8 R9, R5a represents a hydrogen atom, an alkyl group having from 1 to 4 carbon atoms, a benzyl group, an alkanoyloxyalkyl group, in which the alkanoyl part has from 1 to 5 carbon atoms, and the alkyl part is a methyl or ethyl group, a cycloalkanoyloxyalkyl group, in which the cycloalkanoyl part has 6 or 7 carbon atoms, and the alkyl part is a methyl or ethyl group, an alkoxycarbonyloxyalkyl group, in which the alkoxy part has from 1 to 4 carbon atoms, and the alkyl part is a methyl or ethyl group, a cycloalkoxycarbonyloxyalkyl group, in which the cycloalkoxy part has 5 or 6 carbon atoms, and the alkyl part is a methyl or ethyl group, a (5-phenyl-2-oxo-1,3-dioxolen-4-yl)methyl group, a (5-methyl-2-oxo-1,3-dioxolen-4-yl)methyl group, a (5-ethyl-2-oxo-1,3dioxolen-4-yl)methyl group or a phthalidyl group; R8 and R9 are independently selected from the group consisting of hydrogen atoms, methyl groups, ethyl groups, methoxycarbonylmethyl groups, ethoxycarbonylmethyl groups and carboxymethyl groups;
or R8 and R9 together representa tetramethylene, pentamethylene, 1-carboxytetramethylene or 1-carboxypentamethylene group; R6 represents a hydrogen atom, a methyl group, a methoxy group or a fluorine atom or a chlorine atom at the 6-position of the benzene ring;
R7 represents a carboxy group or a tetrazol-5-yl group at the 2-position of the benzene ring;the benzyl ring which bears the substituents represented by R6 and R7 is at the 4-position of the benzyl group to which it is attached; and pharmaceutically acceptable salts and esters thereof. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 35, 36, 37, 38, 39, 40, 41, 42)
- ##STR24## wherein;
-
34. A compound of formula (I):
- ##STR26## wherein;
R1 represents an alkyl group having from 1 to 6 carbon atoms or an alkenyl group having from 3 to 6 carbon atoms;R2 and R3 are independently alkyl groups having from 1 to 6 carbon atoms; R4 represents; a hydrogen atom; an alkyl group having from 1 to 6 carbon atoms; an alkanoyl group having from 1 to 6 carbon atoms; a substituted alkanoyl group having from 2 to 6 carbon atoms and substituted by at least one substituent selected from the group consisting of halogen atoms and alkoxy groups having from 1 to 6 carbon atoms; an alkenoyl group having from 3 to 6 carbon atoms; an arylcarbonyl group in which the aryl part is as defined below; an alkoxycarbonyl group in which the alkyl part has from 1 to 6 carbon atoms; a tetrahydropyranyl, tetrahydrothiopyranyl, tetrahydrothienyl or tetrahydrofuryl group; a substituted tetrahydropyranyl, tetrahydrofuryl group which is substituted by at least one substituent selected from the group consisting of halogen atoms and alkoxy groups having from 1 to 6 carbon atoms; alkoxymethyl groups in which the alkoxy part has from 1 to 6 carbon atoms; (alkoxyalkoxy)methyl groups in which each alkoxy part has from 1 to 6 carbon atoms; haloalkoxymethyl groups in which the alkoxy part has from 1 to 6 carbon atoms; aralkyl groups, in which an alkyl group having from 1 to 6 carbon atoms is substituted by at least one aryl group, as defined below;
oralkanoyloxymethoxycarbonyl groups in which the alkanoyl part has from 1 to 6 carbon atoms; R5 represents a carboxy group or a group of formula --CONR8 R9, wherein R8 and R9 are independently selected from the group consisting of hydrogen atoms, unsubstituted alkyl groups having from 1 to 6 carbon atoms, and substituted alkyl groups which have from 1 to 6 carbon atoms and which are substituted by at least one substituent selected from the group consisting of substituents (a), defined below, or R8 and R9 together represent an unsubstituted alkylene group having from 2 to 6 carbon atoms or a substituted alkylene group which has from 2 to 6 carbon atoms and which is substituted by at least one substituent selected from the group consisting of carboxy groups and alkoxycarbonyl groups in which the alkyl part has from 1 to 6 carbon atoms; R6 represents a hydrogen atom, an alkyl group having from 1 to 6 carbon atoms, an alkoxy group having from 1 to 6 carbon atoms or a halogen atom; R7 represents a carboxy group or a tetrazol-5-yl group;
said substituents (a) are selected from the group consisting of;aryl groups as defined below; heterocyclic groups having 5 or 6 ring atoms, of which from 1 to 4 are hetero-atoms selected from the group consisting of nitrogen, oxygen and sulfur atoms; halogen atoms; hydroxy groups; alkoxy groups having from 1 to 6 carbon atoms; carboxy groups alkoxycarbonyl groups in which the alkyl part has from 1 to 6 carbon atoms; amino groups; and acylamino groups, in which the acyl part is an alkanoyl group having from 1 to 6 carbon atoms or an arylcarbonyl group, in which the aryl part is as defined below; said aryl groups are aromatic carbocyclic groups which have from 6 to 14 ring atoms and which are unsubstituted or are substituted by at least one substituent selected from the group consisting of substituents (b), defined below; and said substituents (b) are selected from the group consisting of nitro groups, cyano groups, halogen atoms, unsubstituted carbocyclic aryl groups having from 6 to 10 ring atoms, alkyl groups having from 1 to 6 carbon atoms, alkoxy groups having from 1 to 6 carbon atoms, carboxy groups, alkoxycarbonyl groups in which the alkoxy part has from 1 to 6 carbon atoms and alkylenedioxy and alkylidene-dioxy groups having from 1 to 3 carbon atoms; and pharmaceutically acceptable salts thereof.
- ##STR26## wherein;
Specification
-
- Resources
Litigation Campaign Assessment
Thank you for your request. You will receive a custom alert email when the Litigation Campaign Assessment is available.
×
Litigation Data
-
Current AssigneeDaiichi Sankyo Company Limited
-
Original AssigneeSankyo Company Limited (Daiichi Sankyo Company Limited)
-
InventorsKanazaki, Takuro, Koike, Hiroyuki, Sada, Toshio, Fujimoto, Koichi, Yanagisawa, Hiroaki, Amemiya, Yoshiya, Shimoji, Yasuo
-
Primary Examiner(s)Springer, David B.
-
Application NumberUS08/378,650Time in Patent Office796 DaysField of Search548/253, 548/315.1, 548/315.4, 548/334.5, 514/381, 514/382, 514/396, 514/397US Class Current514/381CPC Class CodesC07D 233/90 Carbon atoms having three b...C07D 403/10 linked by a carbon chain co...C07D 405/12 linked by a chain containin...C07D 405/14 containing three or more he...C07F 7/1804 Compounds having Si-O-C lin...
