Process for the sulfinylation of heterocyclic compounds

  • US 5,618,945 A
  • Filed: 02/22/1995
  • Issued: 04/08/1997
  • Est. Priority Date: 02/22/1994
  • Status: Expired due to Term
First Claim
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1. A process for the sulfinylation of a heterocyclic compound comprising reacting a compound of the formula RS(O)X, wherein R is straight or branched alkyl having from 1 to 4 carbon atoms, which is substituted with one or more identical or different halogen atoms, and X is a halogen atom, a hydroxyl group or salt thereof, a radical of the formula --NR2 R3 wherein R2 and R3 are alkyl or haloalkyl having from 1 to 4 carbon atoms, or an aryloxy or aralkoxy radical, the aryl portion of which is unsubstituted or is substituted with one or more halogen atoms or alkyl or haloalkyl radicals having from 1 to 4 carbon atoms, with a heterocyclic compound Het selected from the group consisting of pyrroles, pyrazoles, imidazoles, oxazoles, isoxazoles, thiazoles, isothiazoles and triazoles, said heterocyclic compound Het being unsubstituted or being substituted with one or more members selected from the group consisting of halogen, amino which is unsubstituted or is substituted with one or two alkyl having from 1 to 4 carbon atoms, nitrile, aryl, and aryl having one or more substituents selected from the group consisting of halogen, alkyl, haloalkyl and SF5, in the presence of (a) a compound selected from the group consisting of the tosylates, hydrochlorides and mesylates of primary, secondary and tertiary amines, or (b) hydrochloric acid.

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