Biosensor and interface membrane
First Claim
1. A biosensing system including a selectively permeable interface membrane which is separate and distinct from an electrode and protein receiving matrix, and which is used to separate biochemical, optical or other processes from an analyte matrix, said membrane comprising a supporting mesh and a perfluorosulfonic acid polymer impregnated substrate.
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Accused Products
Abstract
A regenerable biosensor probe adapted for positioning in a bioreactor comprises a selectively permeable interface membrane, a porous protein-receiving matrix adjacent to the interface membrane, an indicating electrode, an inlet conduit through which fresh protein conjugate may flow to the protein-receiving matrix, and an outlet conduit through which spent protein conjugate may be removed from the protein-receiving matrix. A selectively permeable interface membrane, which may be used in a biosensor system to separate biochemical, optical or other processes from an analyte matrix comprises a supporting mesh, a perfluorosulfonic acid polymer impregnated substrate and a homogenous film of perfluorosulfonic acid polymer.
A method of preparing this interface membrane comprises fixing a substrate on to a supporting mesh to form a substrate membrane, casting a perfluorosulfonic and polymer on the substrate membrane and curing the product to so formed.
734 Citations
12 Claims
- 1. A biosensing system including a selectively permeable interface membrane which is separate and distinct from an electrode and protein receiving matrix, and which is used to separate biochemical, optical or other processes from an analyte matrix, said membrane comprising a supporting mesh and a perfluorosulfonic acid polymer impregnated substrate.
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4. A method of preparing a selectively permeable interface membrane in a biosensor system which is separate and distinct from an electrode and protein-receiving matrix, and which is used to separate biochemical, optical or other processes from an analyte matrix which comprises:
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fixing a substrate onto a supporting mesh to form a substrate membrane; casting a perfluorosulfonic acid polymer on the substrate membrane; and curing the product so formed. - View Dependent Claims (5, 6, 7, 8, 9)
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10. A regenerable biosensor probe for positioning in an environment characterized by the presence of biological molecules which are substrates for or products produced by enzymes in order to determine the presence of said molecules, said biosensor probe comprising:
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a selectively permeable interface membrane which separates the biochemical and electrochemical processes from the environment when the probe is in place; a porous protein-receiving matrix adjacent to the interface membrane; an indicating electrode covered with an electrically insulative material, said electrode abutting, at one of its ends, the protein-receiving matrix; an inlet conduit through which fresh protein conjugate may flow to the protein-receiving matrix; and an outlet conduit through which spent protein conjugate may be removed from the protein-receiving matrix. - View Dependent Claims (11, 12)
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Specification