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Controlled local delivery of chemotherapeutic agents for treating solid tumors

  • US 5,626,862 A
  • Filed: 08/02/1994
  • Issued: 05/06/1997
  • Est. Priority Date: 08/02/1994
  • Status: Expired due to Term
First Claim
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1. A chemotherapeutic composition comprisinga biocompatible polymeric matrix and a water insoluble, lipid insoluble chemotherapeutic agent, which does not cross the blood-brain barrier,wherein the agent is incorporated into and released from the polymeric matrix by degradation of the matrix or diffusion of the agent out of the matrix over a period of time of at least eight hours in an amount effective to inhibit growth of a solid tumor when administered to the tumor.

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