Intravenous-line air-detection system

• US 5,641,892 A
• Filed: 06/07/1995
• Issued: 06/24/1997
• Est. Priority Date: 06/07/1995
• Status: Expired due to Term

• Current Assignee: Deka Products Limited Partnership
• Original Assignee: Deka Products Limited Partnership
• Inventors: Beavis, Russell, Kamen, Dean L., Larkins, William T.
• Primary Examiner(s): Williams, Hezron E.
• Assistant Examiner(s): Politzer, Jay L.
• Application Number:
  US08/477,380
• Time in Patent Office: 748 Days
• Field of Search: 73/19.03, 73/149, 73/290 B, 73/290 V, 73/61.75
• US Class Current: 73/19.03
• CPC Class Codes: A61M 2005/1402 Priming
• CPC Class Codes: A61M 5/16809 by repeated filling and emptying of an intermediate volume pressure infusion using positive displacement pumps A61M5/142
• CPC Class Codes: A61M 5/365 Air detectors A61M5/1684 takes precedence; in extracorporeal blood circuits A61M1/3626
• CPC Class Codes: G01N 2291/02433 Gases in liquids, e.g. bubbles, foams
• CPC Class Codes: G01N 29/036 by measuring frequency or resonance of acoustic waves
• CPC Class Codes: G01N 29/12 by measuring frequency or resonance of acoustic waves measuring frequency or resonant frequency of mechanical vibrations or acoustic waves in general G01H1/06, G01H3/04, G01H13/00; acoustic resonators G10K11/04; vibration or shock testing of structures G01M7/00

Abstract

The flow of an intravenous (IV) fluid from a IV source through an IV line to a patient is controlled, while monitoring whether there is any bubble in the liquid being delivered to the patient. Disposed in the line is a region having a first portion containing a measurement gas and a second portion containing a segment of the liquid flowing through the line. The liquid in this region is tested for the presence of an air bubble. The sum of the first portion'"'"'s volume and the second portion'"'"'s volume should be a constant volume. The region is part of an acoustically resonant system, in the volume of the measurement gas in the first portion of the region can be determined from the resonant frequency. Preferably, the acoustically resonant system is tuned so as to prevent the presence of a bubble from significantly affecting the measurement of the volume of the region'"'"'s first portion. The region should be isolatable from pressure effects in the rest of the line, preferably by means of a first valve that controls flow from the source and a second valve that controls flow to the patient. The resonant system includes at least one speaker and one microphone, arranged so that the resonant frequency of the system can be detected. In addition, some means for changing the pressure of the measurement gas in the resonant system is provided.

Claims

1. A method for detecting the presence of a bubble in a liquid, the method comprising:

providing an acoustically resonant system having a region, the region having a first portion containing a measurement gas and a second portion containing the liquid in which the presence of the bubble is to be detected, the sum of the first portion'"'"'s volume and the second portion'"'"'s volume being a constant volume;

determining the resonant frequency of the system at a first pressure of the measurement gas;

changing the pressure of the measurement gas to a second pressure;

determining the resonant frequency of the system at the second pressure;

determining, based on the resonant frequency measured at the first pressure and the resonant frequency measured at the second pressure, whether the volume of the first portion has changed due to the change in pressure; and

if the volumes at the first and second pressures are different, generating a signal indicating the presence of a bubble in the liquid.

2. A method according to claim 1, wherein the acoustically resonant system is tuned so as to prevent the presence of a bubble from significantly affecting a determination of the volume of the region'"'"'s first portion based on the resonant frequency.

3. A method for controlling the flow of a liquid from a intravenous fluid source through an intravenous line to a patient and detecting the presence of a bubble in the liquid, the method comprising:

providing in the line a region having a first portion containing a measurement gas and a second portion containing a segment of the liquid flowing through the line, the sum of the first portion'"'"'s volume and the second portion'"'"'s volume being a constant volume, the region being part of an acoustically resonant system, the region being isolatable from pressure effects in the rest of the line by means of a first valve that controls flow from the source and a second valve that controls flow to the patient;

closing the second valve and opening the first valve to permit flow from the source into the region;

after liquid has flowed from the source into the region, closing the first valve so as to isolate the region from pressure effects in the line;

determining the resonant frequency of the system at a first pressure of the measurement gas;

after closing the first valve, changing the pressure of the measurement gas to a second pressure;

determining the resonant frequency of the system at the second pressure;

determining, based on the resonant frequency measured at the first pressure and the resonant frequency measured at the second pressure, whether the volume of the first portion has changed due to the change in pressure; and

if no change in volume is detected due to the change in pressure, opening the second valve to permit flow to the patient, and if a change in volume is detected, generating a signal indicating the presence of a bubble in the liquid.

4. A method according to claim 3, further including the step of purging liquid from the second portion of the region to the fluid source in response to the signal indicating the presence of a bubble in the liquid.

5. A method according to claim 4, wherein the acoustically resonant system is tuned so as to prevent the presence of a bubble from significantly affecting a determination of the volume of the region'"'"'s first portion based on a resonant frequency.

6. A method according to claim 4, further including the steps of

determining, based on a measured resonant frequency, the volume of the measurement gas in the region'"'"'s first portion before opening the second valve to permit flow to the patient;

closing the second valve after a volume of liquid has flowed to the patient;

determining the resonant frequency after the second valve is closed;

determining the first portion'"'"'s volume based on the resonant frequency determined after the second valve was closed; and

determining the volume of liquid delivered to the patient by subtracting the volume of the first portion determined before the second valve was opened from the volume determined after the second valve was closed.

7. A method according to claim 6, wherein the acoustically resonant system is tuned so as to prevent the presence of a bubble from significantly affecting a determination of the volume of the region'"'"'s first portion based on a resonant frequency.

8. An apparatus for detecting the presence of a bubble in a liquid, the apparatus comprising:

an acoustically resonant system having a region isolated from extraneous pressure effects, the region having a first portion containing a measurement gas and a second portion containing the liquid in which the presence of the bubble to be detected, the sum of the first portion'"'"'s volume and the second portion'"'"'s volume being a constant volume;

means for detecting the resonant frequency of the system;

means for changing the pressure of the measurement gas in the system; and

signal generating means for generating a signal indicating the presence of a bubble in the liquid, wherein the signal generating means is in communication with the means for detecting the resonant frequency and the means for changing the pressure of the measurement gas, wherein the signal is generated based upon a first and a second resonant frequency determined by the means for detecting the resonant frequency when the means for changing the pressure has caused the measurement gas to have a first and second pressure, respectively.

9. An apparatus according to claim 8, wherein the acoustically resonant system is tuned so as to prevent the presence of a bubble from significantly affecting a determination of the volume of the region'"'"'s first portion based on a resonant frequency.

10. An apparatus according to claim 8, wherein the acoustically resonant system includes

a back chamber, and

a port containing a resonatable mass and connecting the back chamber to the first portion of the region, and

wherein the resonance-detection means includes

a speaker for introducing acoustic energy into the acoustically resonant system at a variety of frequencies, and

a microphone for detecting the response of the acoustically resonant system to the acoustic energy introduced into the system by the speaker.

11. An apparatus according to claim 10, wherein the microphone is in communication with the back chamber and the speaker forms a portion of a wall of the back chamber.

12. An apparatus according to claim 11, wherein the resonance-detection means further includes

a service chamber, in which the speaker forms a portion of the wall of the service chamber and separates the service chamber from the back chamber, and

a service microphone in communication with the service chamber.

13. An apparatus according to claim 12, wherein the acoustically resonant system is tuned so as to prevent the presence of a bubble from significantly affecting a determination of the volume of the region'"'"'s first portion based on a resonant frequency.

14. An apparatus for controlling the flow of a liquid from a intravenous fluid source through an intravenous line to a patient and detecting the presence of a bubble in the liquid, the apparatus comprising:

a region having a first portion containing a measurement gas and a second portion containing a segment of the liquid flowing through the line in which the presence of the bubble is to be detected, the sum of the first portion'"'"'s volume and the second portion'"'"'s volume being a constant volume, the region being part of an acoustically resonant system, the system having different frequencies of resonance for different volumes of the measurement gas in the first portion of the region, the region being isolatable from pressure effects in the rest of the line by means of a first valve that controls flow from the source and a second valve that controls flow to the patient;

means for detecting the resonant frequency of the system;

means for changing the pressure of the measurement gas; and

a controller for controlling the valves, the resonance-detection means, and the pressure-changing means, for determining, based on the resonant frequencies measured at two different pressures, whether the volume of the first portion changes due to a change in pressure and for generating a signal indicating the presence of a bubble in the liquid if the first portion'"'"'s volume does change due to a change in pressure.

15. An apparatus according to claim 14, wherein the controller causes the second valve to permit flow to the patient if no change in the first portion'"'"'s volume is determined.

16. An apparatus according to claim 15, further including means for purging liquid from the second portion of the region to the fluid source in response to the signal indicating the presence of a bubble in the liquid.

17. An apparatus according to claim 16, wherein the acoustically resonant system is tuned so as to prevent the presence of a bubble from significantly affecting a determination of the volume of the region'"'"'s first portion based on a resonant frequency.

18. An apparatus according to claim 17, further including means for determining the volume of the region'"'"'s first portion based on a measured resonant frequency.

19. An apparatus according to claim 18, wherein the acoustically resonant system includes

a back chamber, and

a port containing a resonatable mass and connecting the back chamber to the first portion of the region,

wherein the resonance-detection means includes

a speaker for introducing acoustic energy into the acoustically resonant system at a variety of frequencies, and

a microphone for detecting the response of the acoustically resonant system to the acoustic energy introduced into the system by the speaker, and

wherein the microphone is in communication with the back chamber and the speaker forms a portion of a wall of the back chamber.

20. An apparatus according to claim 19, wherein the resonance-detection means further includes

a service chamber, in which the speaker forms a portion of the wall of the service chamber and separates the service chamber from the back chamber, and

a service microphone in communication with the service chamber.