Non-antigenic branched polymer conjugates

  • US 5,643,575 A
  • Filed: 10/27/1993
  • Issued: 07/01/1997
  • Est. Priority Date: 10/27/1993
  • Status: Expired due to Term
First Claim
Patent Images

1. A branched substantially non-antigenic polymer comprising the formula:

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    space="preserve" listing-type="equation">(R).sub.n L-Awherein (R) is a water soluble, substantially non-antigenic polymer containing a C1 -C4 terminal group;

    (n)=2 or 3;

    (A) is a functional group capable of bonding with a biologically active nucleophile selected from the group consisting of proteins, peptides, polypeptides, enzymes and chemotherapeutic molecules or a moiety capable of being functionalized to react with said nucleophile; and

    (L) is selected from the group consisting of ##STR16## wherein (α

    ) is 1 to 5.

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