DNA encoding antibodies with altered effector functions

  • US 5,648,260 A
  • Filed: 06/07/1995
  • Issued: 07/15/1997
  • Est. Priority Date: 03/18/1987
  • Status: Expired due to Term
First Claim
Patent Images

1. Isolated DNA encoding at least part of a constant region of an immunoglobulin heavy chain in which at least one amino acid selected from the group consisting of amino acid residues 234, 235, 236, 237, 297, 318, 320 and 322 is substituted with an amino acid which is different from that present in an unmodified antibody thereby causing an alteration in an effector function while retaining binding to antigen as compared with the unmodified antibody.

View all claims

    Thank you for your feedback