Non-invasive localization of a light-emitting conjugate in a mammal

  • US 5,650,135 A
  • Filed: 07/01/1994
  • Issued: 07/22/1997
  • Est. Priority Date: 07/01/1994
  • Status: Expired due to Term
First Claim
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1. A noninvasive method for detecting the localization of an entity under study from within a mammalian subject, comprising(a) administering to the subject a conjugate or transformed cell of the entity and a light-generating moiety or a transformed cell expressing the light-generating moiety,(b) after a period of time in which the conjugate or transformed cell can achieve localization in the subject, immobilizing the subject within the detection field of a photodetector device,(c) maintaining the subject in an immobilized condition,(d) during said maintaining, measuring photon emission from the light-generating moiety, localized in the subject, with the photodetector device until an image of photon emission can be constructed, and(e) detecting said image through an opaque tissue of said mammal.

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