Closed porous chambers for implanting tissue in a host

• US 5,653,756 A
• Filed: 09/02/1994
• Issued: 08/05/1997
• Est. Priority Date: 10/31/1990
• Status: Expired due to Term

• Current Assignee: Baxalta GmbH (Shire plc), Baxalta Incorporated (Shire plc)
• Original Assignee: Baxter International Inc.
• Inventors: Clarke, Robert A., Brauker, James H., Boggs, Daniel R., Sternberg, Shmuel, Pauley, Robin G., Hill, Ronald S.
• Primary Examiner(s): Clarke, Robert A.
• Application Number:
  US08/300,173
• Time in Patent Office: 1,068 Days
• Field of Search: 623/11, 623/66, 623/901, 424/422, 424/423, 424/424, 424/425, 604/890.1-892.1, 435/240, 435/241, 435/284, 435/285, 435/301
• US Class Current: 623/11.11
• CPC Class Codes: A61B 5/14532 for measuring glucose, e.g. by tissue impedance measurement
• CPC Class Codes: A61F 2/022 Artificial gland structures using bioreactors hemodialysis A61M1/16; hemofiltration A61M1/34; other extracorporeal blood treatment A61M1/36
• CPC Class Codes: A61K 9/0024 Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue compositions for intravenous administration, normal injectable solutions or dispersions for, e.g. subcutaneous administration A61K9/0019; brain implants A61K9/0085; (coated) prostheses, catheters or stents A61L
• CPC Class Codes: A61L 27/38 containing added animal cells organs or tissue containing native cells A61L27/36
• CPC Class Codes: A61L 27/56 Porous materials, e.g. foams or sponges
• CPC Class Codes: A61L 29/005 Ingredients of undetermined constitution or reaction products thereof
• CPC Class Codes: A61L 29/146 Porous materials, e.g. foams or sponges
• CPC Class Codes: Y10S 623/901 Method of manufacturing prosthetic device

Abstract

Improved Implant assemblies and methodologies provide immuno-protection for implanted allografts, xenografts, and isografts. The assemblies and methodologies establish an improved chamber for holding the implanted cells. The chambers include first and second wall elements and an intermediate sealing element. The first and second wall elements overlie an open area in the sealing member to form a chamber for holding cells for implantation. A sealed region is created between the wall elements and the sealing element body to close the chamber. In one arrangement, the sealed region is created by means of a sonic weld made while the implanted cells are present in the chamber. In another arrangement, the sealed region is created by means of applying an external force to compress the peripheral edges of the wall elements and the sealing element together while the implanted cells are present in the chamber.

Claims

1. A chamber and cells for implanting into host tissue comprising

a first and second wall elements, each having a peripheral edge,

a quantity of living cells intended for implantation in host tissue,

a sealing element having a body peripherally surrounding an open area, the sealing element being located between the first and second wall elements with the sealing element body sandwiched between the peripheral edges of the first and second wall elements and the first and second wall elements jointly overlying the open area of the sealing member to form a chamber for holding the living cells,

means for creating a sealed region between the peripheral edges of the wall elements and the sealing element body to close the chamber comprising a sonic weld made while the implanted cells are present in the chamber, and

both the first and second wall elements together with the sealed region isolating the living cells within the chamber from an immune response of the host tissue, at least one of the first and second wall elements being sufficiently permeable to nutrients for transferring the nutrients from host tissue through the at least one wall element to the living cells present within the chamber.