Instrument and method for non-invasive monitoring of human tissue analyte by measuring the body's infrared radiation
First Claim
1. A method of determining a human body tissue analyte concentration by non invasive measurement of emission spectral lines characteristic to a body tissue analyte in an infrared spectral region emitted naturally by a human body as heat, comprising:
- a. measuring a spectral intensity of said emission spectral lines;
b. said emission spectral lines having a wavelength dependence of tissue constituents;
c. detecting the emission spectral lines at a predetermined emission wavelength;
d. analyzing the emission spectral lines in said infrared spectral region;
e. correlating said spectral intensity of emission spectral lines with body analyte concentrations.
2 Assignments
0 Petitions
Accused Products
Abstract
A method and an instrument for the non-invasive detection of an analyte (e.g. glucose) concentration in human body tissue such as blood is disclosed. The instrument measures analyte (e.g. glucose) concentration by detecting the infrared radiation naturally emitted by a human body using infrared detector with combination of adequate filters such as for example negative correlation filter or narrow band filters or other detector-filter assemblies. The method and instrument is based on the discovery that natural infrared emission from the human body, especially from the tympanic membrane, is modulated by the state of the emitting tissue. Spectral emissivity of human infrared radiation from the tympanic membrane consists of spectral information of the tissue (e.g. blood) analyte (e.g. glucose). This can be directly correlated with the blood analyte concentration, for example, the blood glucose concentration.
181 Citations
9 Claims
-
1. A method of determining a human body tissue analyte concentration by non invasive measurement of emission spectral lines characteristic to a body tissue analyte in an infrared spectral region emitted naturally by a human body as heat, comprising:
-
a. measuring a spectral intensity of said emission spectral lines; b. said emission spectral lines having a wavelength dependence of tissue constituents; c. detecting the emission spectral lines at a predetermined emission wavelength; d. analyzing the emission spectral lines in said infrared spectral region; e. correlating said spectral intensity of emission spectral lines with body analyte concentrations. - View Dependent Claims (2)
-
-
3. An instrument for determining a human body tissue analyte concentration by non-invasive measurement of emission spectral lines characteristic to a body tissue analyte in an infrared spectral region emitted naturally by a human body as heat, comprising:
-
a. a means for detecting said emission spectral lines at a predetermined infrared wavelength; b. a means for detecting a spectral intensity of the emission spectral lines; c. a means for correlating the intensity of emission spectral lines with the tissue analyte concentration. - View Dependent Claims (4, 5, 6, 7, 8)
-
-
9. An instrument for non-invasive tissue analyte concentration measurement based on measurement of emission spectral lines characteristic to a human body tissue analyte in an infrared spectral region emitted naturally by a tympanic membrane as heat, comprising:
-
a. a speculum for insertion into an ear canal; b. a plastic cover made of a material transparent to radiation in an infrared spectral region; c. an infrared wave guide for receiving infrared radiation from the tympanic membrane and for illuminating all windows of a detecting system; d. the infrared wave guide is selected from the group consisting of a mirror, reflector, lens, hollow tube, and a fiber optic; e. an optical valve consisting of a shutter or chopper; f. the detecting system consisting of an optical infrared filter set and a detector sensitive in an infrared region of human body heat radiation; g. an optical infrared filter set consisting of a negative correlating filter or narrow band filters; h. a detector system sensitive in the infrared region of human body heat radiation consisting of at least two sensing areas electronically connected so that their outputs are subtracted; i. said detector connected with electronics, a microprocessor and a display system for forming, calculating, and displaying an electrical signal from the detector to show a numerical value of the analyte concentration.
-
Specification