Method of making blood gas sensors overcoats using permeable polymeric compositions
First Claim
1. A method for making a shaped permeable polymeric material, the method comprising:
- (a) preparing a crosslinkable composition comprising a hydrophobic portion and a hydrophilic portion, wherein the hydrophobic portion is a polymeric material selected from the group consisting of a polysulfone, a polyethersulfone, a polyarylsulfone, a polyimide, a polyarylate, a cellulose acetate, a polyurethane, a polycarbonate, a polyester carbonate a phenoxy resin, a polyether imide, a cellulose acetate butyrate, a nylon, a polyvinyl butyral, a polyarylene oxide, a poly(urea urethane), a polyphenyl quinoxaline, and mixtures thereof;
(b) placing the crosslinkable composition in a mold;
(c) gelling the crosslinkable composition to form a shaped gelled composition comprising a hydrophobic portion, a hydrophilic portion, and a liquid portion; and
(d) exchanging the liquid portion with an exchange liquid to form a shaped permeable polymeric material having a tensile strength, when fully hydrated, of at least about 525 psi (3620 kPa).
2 Assignments
0 Petitions
Accused Products
Abstract
The present invention provides a shaped permeable polymeric material including a hydrophobic portion and a hydrophilic portion, wherein the material is crosslinked. This material is prepared by a method including the steps preparing a crosslinkable composition having a hydrophobic portion and a hydrophilic portion; placing the crosslinkable composition in a mold; gelling the crosslinkable composition to form a shaped gelled polymeric composition comprising a hydrophobic portion, a hydrophilic portion, and a liquid portion; and exchanging the liquid portion with an exchange liquid to form the permeable polymeric material. Preferably this material is used in a blood gas sensor.
97 Citations
39 Claims
-
1. A method for making a shaped permeable polymeric material, the method comprising:
-
(a) preparing a crosslinkable composition comprising a hydrophobic portion and a hydrophilic portion, wherein the hydrophobic portion is a polymeric material selected from the group consisting of a polysulfone, a polyethersulfone, a polyarylsulfone, a polyimide, a polyarylate, a cellulose acetate, a polyurethane, a polycarbonate, a polyester carbonate a phenoxy resin, a polyether imide, a cellulose acetate butyrate, a nylon, a polyvinyl butyral, a polyarylene oxide, a poly(urea urethane), a polyphenyl quinoxaline, and mixtures thereof; (b) placing the crosslinkable composition in a mold; (c) gelling the crosslinkable composition to form a shaped gelled composition comprising a hydrophobic portion, a hydrophilic portion, and a liquid portion; and (d) exchanging the liquid portion with an exchange liquid to form a shaped permeable polymeric material having a tensile strength, when fully hydrated, of at least about 525 psi (3620 kPa). - View Dependent Claims (2, 3, 4, 5, 12, 13, 14, 15, 31, 36, 37)
-
-
6. A method for making a coated blood gas sensor, the method comprising:
-
(a) preparing a crosslinkable composition comprising a hydrophobic portion and a hydrophilic portion, wherein the hydrophobic portion of the crosslinkable composition comprises a hydrophobic polymeric material; (b) placing the crosslinkable composition and a portion of the sensor in a mold; (c) gelling the crosslinkable composition to form a shaped gelled composition comprising a hydrophobic portion, a hydrophilic portion, and a liquid portion; and (d) exchanging the liquid portion with an exchange liquid to form a shaped permeable polymeric material coated on the sensor having a tensile strength, when fully hydrated, of at least about 650 psi (4482 kPa). - View Dependent Claims (7, 8, 9, 10, 11, 32, 33)
-
-
16. A method for making a shaped permeable polymeric material, the method comprising:
-
(a) preparing a crosslinkable composition comprising a hydrophobic polymeric material, a hydrophilic monomeric material, and an organic solvent, wherein the hydrophobic polymeric material is selected from the group consisting of a polysulfone, a polyethersulfone, a polyarylsulfone, a polyimide, a polyarylate, a cellulose acetate, a polyurethane, a polycarbonate, a polyester carbonate, a phenoxy resin, a polyether imide, a cellulose acetate butyrate, a nylon, a polyvinyl butyral, a polyarylene oxide, a poly(urea urethane), a polyphenyl quinoxaline, and mixtures thereof; (b) placing the crosslinkable composition in a mold; (c) gelling the crosslinkable composition to form a shaped gelled composition comprising a hydrophobic portion, a hydrophilic portion, and a liquid portion; and (d) exchanging the liquid portion with an exchange liquid to form a shaped permeable polymeric material having a tensile strength, when fully hydrated, of at least about 525 psi (3620 kPa). - View Dependent Claims (17, 18, 19, 20, 21, 34, 38)
-
-
22. A method for making a shaped permeable polymeric material, the method comprising:
-
(a) preparing a crosslinkable composition comprising a hydrophobic portion and a hydrophilic portion, wherein the hydrophobic portion is a polymeric material selected from the group consisting of a polysulfone, a polyethersulfone, a polyarylsulfone, a polyimide, a polyarylate, a cellulose acetate, a polyurethane, a polycarbonate, a polyester carbonate, a phenoxy resin, a polyether imide, a cellulose acetate butyrate, a nylon, a polyvinyl butyral, a polyarylene oxide, a poly(urea urethane), a polyphenyl quinoxaline, and mixtures thereof; (b) placing the crosslinkable composition in a mold; (c) gelling the crosslinkable composition to form a shaped gelled composition comprising a hydrophobic portion, a hydrophilic portion, and a liquid portion; (d) evaporating the liquid portion; and (e) adding an exchange liquid to form a shaped permeable polymeric material having a tensile strength, when fully hydrated, of at least about 525 psi. - View Dependent Claims (23, 24, 35)
-
-
25. A method for making a coated blood gas sensor, the method comprising:
-
(a) preparing a crosslinkable composition comprising a hydrophobic portion and a hydrophilic portion; (b) placing the crosslinkable composition and a portion of the sensor in a mold; (c) gelling the crosslinkable composition to form a shaped gelled composition comprising a hydrophobic portion, a hydrophilic portion, and a liquid portion; and (d) exchanging the liquid portion with an exchange liquid to form a shaped permeable polymeric material coated on the sensor having a tensile strength, when fully hydrated, of at least about 525 psi. - View Dependent Claims (26, 27, 28, 29, 30)
-
-
39. A method for making a coated blood gas sensor, the method comprising:
-
(a) preparing a crosslinkable composition comprising a hydrophobic portion selected from the group consisting of a polysulfone, a polyethersulfone, a polyarylsulfone, a polyimide, a polyarylate, a cellulose acetate, a polyurethane, a polycarbonate, a polyester carbonate, a phenoxy resin, a silicone, a polyether imide, a cellulose acetate butyrate, a nylon, a polyvinyl butyral, a polyarylene oxide, a poly(urea urethane), a polyphenyl quinoxaline, and mixtures thereof, and a hydrophilic portion selected from the group consisting of N-vinyl pyrrolidone, N,N-dimethyl acrylamide, N-vinyl-N-methyl acetamide, N-vinyl valerolactam, N-vinyl caprolactam, acrylamide, acrylic acid, hydroxy ethyl acrylate, hydroxy ethyl methacrylate, poly(ethylene glycol) methyl ether acrylate, and mixtures or copolymers thereof; (b) placing the crosslinkable composition and a portion of the sensor in a mold; (c) gelling the crosslinkable composition to form a shaped gelled composition comprising a hydrophobic portion, a hydrophilic portion, and a liquid portion; and (d) exchanging the liquid portion with an exchange liquid to form a shaped permeable polymeric material coated on the blood gas sensor.
-
Specification