Porous material product and process

• US 5,681,572 A
• Filed: 11/22/1993
• Issued: 10/28/1997
• Est. Priority Date: 10/18/1991
• Status: Expired due to Term

• Current Assignee: SM Technologies LLC
• Original Assignee: William J. Seare Jr
• Inventors: Seare, William J. Jr.
• Primary Examiner(s): Page, Thurman K.
• Assistant Examiner(s): Benston, Jr., William E.
• Application Number:
  US08/156,675
• Time in Patent Office: 1,436 Days
• Field of Search: 424/436, 424/400, 424/422, 424/423, 673/16, 623/16, 3/1.912
• US Class Current: 424/400
• CPC Class Codes: A61F 2310/00161 Carbon; Graphite
• CPC Class Codes: A61L 27/08 Carbon ; Graphite
• CPC Class Codes: A61L 27/56 Porous materials, e.g. foams or sponges
• CPC Class Codes: A61L 27/58 Materials at least partially resorbable by the body
• CPC Class Codes: C08J 9/26 by elimination of a solid phase from a macromolecular composition or article, e.g. leaching out
• CPC Class Codes: C08J 9/405 with polymerisable compounds

Abstract

A method of preparing a device of a selected material to have pores and pore interconnections of predetermined sizes and shapes includes the steps of forming a selectively removable open-celled porous mold form of particles which adhere to one another, with the particles corresponding to the predetermined pore sizes and shapes, and interconnections between the particles which bind them together in the form in which the connections correspond to the predetermined sizes and shapes of the pore connections. Also included are the steps of filling the vacancies between the particles and connections of the form with the selected material, and then removing the form to leave the selected material. The resulting device is at least partly porous, the pores and pore interconnections corresponding in size and shape to the particles and connections respectively.

Claims

1. A device comprising one or more porous portions, said porous portions useful for promoting neovascularization and ingrowth of vascularized tissue, each of said porous portions comprising:

tissue contacting means for promoting ncovascularization and ingrowth of vascularized tissue and for minimizing formation of fibrous, scar, or capsule tissue, said tissue contacting means comprising;

a) a plurality of pores;

b) a plurality of pore interconnections;

c) said pores being each connected to at least one adjacent pore;

d) said pores being substantially continuously interconnected with each other to thereby form an open-cell configuration; and

wherein the pores and pore interconnections have surfaces which are substantially smoothly flowing and substantially free of sharp edges.

2. A device as described in claim 1 wherein the open-cell configuration comprises a depth of greater than one pore in three dimensions substantially throughout the entirety of the porous portion.

3. A device as described in claim 1 wherein a substantial portion of the pores are selectively sized within a range of approximately 20 μ

m to 1,000 μ

m.

4. A device as described in claim 1 wherein a substantial portion of the pores are selectively sized within a range of approximately 25 μ

m to 150 μ

m.

5. A device as described in claim 1 wherein the configured pores and pore interconnections are formed in layers wherein each said layer has a different porosity.

6. A device as described in claim 1 wherein the tissue contacting means further comprises fibers oriented such that portions of the fibers extend into the pores and pore interconnections.

7. A device as described in claim 1 wherein the tissue contacting means further comprises a Dacron mesh material.

8. A device as described in claim 1 wherein the tissue contacting means further comprises a substance within the pores and pore interconnections.

9. A device as described in claim 8 wherein the substance is dissolvable in situ.

10. A device as described in claim 8 wherein the substance comprises a pharmaceutical composition.

11. A device as described in claim 1 wherein the device comprises an electrode.

12. A doubly porous device for promoting neovascularization and ingrowth of vascularized tissue, said device comprising:

a first porous portion and a second porous portion, said first and second porous portions separated by a membrane and wherein at least one of said porous portions includes;

tissue contacting means for promoting neovascularization and ingrowth of vascular tissue and for minimizing formation of fibrous, scar, or capsule tissue, said tissue contacting means comprising;

a) a plurality of pores;

b) a plurality of pore interconnections;

c) said pores being each connected to at least one adjacent pore;

d) said pores being substantially continuously interconnected with each other to thereby form an open-cell configuration; and

wherein the pores and pore interconnections have surfaces which are substantially smoothly flowing and substantially free of sharp edges.

13. A doubly porous device as described in claim 12 further comprising blood oxygenation means for oxygenating blood within vascular tissue ingrown into said first porous portion, said oxygenation means comprising a selected oxygen-containing medium within said second porous portion and wherein said membrane separating said first and second porous portions is permeable to permit oxygen exchange therethrough.

14. A doubly porous device as described in claim 12 further comprising blood dialysis means for dialyzing blood within vascular tissue ingrown into said first porous portion, said dialysis means comprising a selected dialysate within said second porous portion and wherein said membrane separating said first and second porous portions is permeable to permit dialysis therethrough.

15. A doubly porous device as described in claim 12 further comprising a selected material placed within at least one of said porous portions.