Delayed release microtablet of .beta.-phenylpropiophenone derivatives

  • US 5,681,588 A
  • Filed: 10/03/1995
  • Issued: 10/28/1997
  • Est. Priority Date: 04/03/1993
  • Status: Expired due to Term
First Claim
Patent Images

1. A cylindrical delayed release microtablet with a convex or flat upper side and lower side of β

  • -phenylpropiophenone derivatives of the formula I as active ingredient ##STR2## where R is n-propyl or 1,1-dimethylpropyl, and their pharmacologically acceptable salts, whereina) the height and diameter are, independently of one another, 1-3 mm,b) the active ingredient content is in the range from 81 to 99.9% of the weight of the microtablet,c) the active ingredient density is greater than 1,d) the release of active ingredient in the USP paddle method at 50 rpm is 80% as a maximum after 3 hours and as a minimum after 24 hours,e) the release rate is virtually independent of the pressure when compressing the tablets, andf) the tablet contains no release-delaying ancillary substance but 0.1-5% by weight of a lubricant and 0-18.9% by weight of other conventional ancillary substances.

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