Dry mix formulation for bisphosphonic acids

  • US 5,681,590 A
  • Filed: 07/26/1995
  • Issued: 10/28/1997
  • Est. Priority Date: 12/02/1992
  • Status: Expired due to Fees
First Claim
Patent Images

1. A process for the preparation of a tablet containing an active ingredient selected from:

  • 4-amino-1-hydroxybutylidene-1,1-bisphosphonic acid;

    N-methyl-4-amino-1-hydroxybutylidene-1,1-bis-phosphonic acid;

    4-(N,N-dimethylamino)-1-hydroxybutylidene-1,1-bisphosphonic acid;

    3-amino-1-hydroxypropylidene-1,1-bisphosphonic acid;

    3-(N,N-dimethylamino)-1-hydroxypropylidene-1,1-bisphosphonic acid;

    1-hydroxy-3-(N-methyl-N-pentylamino)propylidene-1,1-bisphosphonic acid;

    1-hydroxy-2- 3-pyridyl!ethylidene-1,1-bisphosphonic acid;

    4-(hydroxymethylene-1,1-bisphosphonic acid)piperidine;

    or a pharmaceutically acceptable salts thereof;

    which process comprises;

    forming a mixture by mixing the active ingredient with;

    a diluent, selected from;

    anhydrous lactose and hydrous fastflow lactose,a dry binder,a disintegrant,and optionally one or more additional ingredients selectedfrom the group consisting of;

    compression aids, flavors,flavor enhancers, sweeteners and preservatives;

    lubricating the mixture with a lubricant; and

    compressing the resultant lubricated mixture into a desiredtablet form.

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