Durable hydrophilic surface coatings

• US 5,700,559 A
• Filed: 12/16/1994
• Issued: 12/23/1997
• Est. Priority Date: 12/16/1994
• Status: Expired due to Term

• Current Assignee: Surface Technology Limited Liability Company
• Original Assignee: Surface Technology Limited Liability Company
• Inventors: Sheu, Min-Shyan, Loh, Ih-Houng
• Primary Examiner(s): NAKARANI, DHIRAJLAL S
• Application Number:
  US08/357,415
• Time in Patent Office: 1,103 Days
• Field of Search: 428/319.7, 428/319.9, 428/407, 428/420
• US Class Current: 428/319.7
• CPC Class Codes: A61L 27/34 Macromolecular materials
• CPC Class Codes: B01D 67/0088 Physical treatment with compounds, e.g. swelling, coating or impregnation
• CPC Class Codes: B01D 67/0093 Chemical modification
• CPC Class Codes: C08J 2479/00 Characterised by the use of macromolecular compounds obtained by reactions forming in the main chain of the macromolecule a linkage containing nitrogen with or without oxygen, or carbon only, not provided for in groups C08J2461/00 - C08J2477/00
• CPC Class Codes: C08J 7/0427 with only one layer of a composition containing a polymer binder with more layers C08J7/042
• CPC Class Codes: C08J 7/046 Forming abrasion-resistant coatings; Forming surface-hardening coatings
• CPC Class Codes: C08J 7/056 Forming hydrophilic coatings
• CPC Class Codes: Y10T 428/249992 Linear or thermoplastic
• CPC Class Codes: Y10T 428/249993 Hydrocarbon polymer
• CPC Class Codes: Y10T 428/2991 Coated
• CPC Class Codes: Y10T 428/2998 including synthetic resin or polymer
• CPC Class Codes: Y10T 428/31507 Of polycarbonate
• CPC Class Codes: Y10T 428/31511 Of epoxy ether
• CPC Class Codes: Y10T 428/31536 Including interfacial reaction product of adjacent layers
• CPC Class Codes: Y10T 428/3154 Of fluorinated addition polymer from unsaturated monomers
• CPC Class Codes: Y10T 428/31573 Next to addition polymer of ethylenically unsaturated monomer
• CPC Class Codes: Y10T 428/31663 As siloxane, silicone or silane
• CPC Class Codes: Y10T 428/31721 Of polyimide
• CPC Class Codes: Y10T 428/31743 Next to addition polymer from unsaturated monomer[s]
• CPC Class Codes: Y10T 428/31797 Next to addition polymer from unsaturated monomers
• CPC Class Codes: Y10T 428/31855 : Of addition polymer from unsaturated monomers
• CPC Class Codes: Y10T 428/31909 : Next to second addition polymer from unsaturated monomers
• CPC Class Codes: Y10T 428/31913 : Monoolefin polymer

Abstract

A hydrophilic article for use in aqueous environments, including a substrate, an ionic polymeric layer on said substrate, and a disordered polyelectrolyte coating ionically bonded to said polymeric layer.

Claims

1. A hydrophilic article for use in aqueous environments, comprising

a porous substrate;

an ionic polymeric layer on said substrate; and

a disordered polyelectrolyte coating ionically bonded to said polymeric layer;

wherein said porous substrate has a surface with pores of an average diameter between 0.01 microns and 1 mm, or is made of perforated material.

2. The article of claim 1, wherein a drop of water placed on said coating is absorbed in less than 1 second after said article is subjected to dry storage at 25°

C. for 3 months.

3. The hydrophilic article of claim 2, wherein

said polymeric layer comprises a polymer selected from the group consisting of (A) polyethylene, polypropylene, polystyrene, polyester, polycarbonates, silicone polymers, polyurethane, polyamides, polyimides, polyalkylacrylates, polyalkylmethacrylates, and fluorocarbon polymers;

(B) poly-2-hydroxylethylmethacrylate, polyhydroxylalkyl methacrylates, polyhydroxylalkyl acrylates, polyacrylic amides, polymethacrylic amides, polyvinyl alcohols, polyethylene oxide, and polyvinyl pyrrolidone;

(C) polylactic acid, polyglycolic acid, polyglycolide-co-lactides, polydioxanones, poly(glycolide-co-trimethylene carbonates), polyethylene carbonates, polyiminocarbonates, poly-β

-hydroxybutyrates, polyesteramides, polyorthoesters, polyanhydrides, and cyanoacrylates; and

(D) copolymers of members of (A), (B) and (C); and

said polyelectrolyte coating comprises a polyelectrolyte selected from the group consisting of polyethyleneimine, polyaminoalkyl methacrylate, polyvinylpyridine, polylysine, polyacrylic acid, polymethacrylic acid, polysulfonic acid, polyvinyl sulfate, polyacrylamido-2-methyl-1-propanesulfonic acid, and polystyrene sulfonic acid.

4. The article of claim 3, wherein said article is a matrix which retains solids, cells, or a target component.

5. The article of claim 1, wherein a drop of water placed on said coating is absorbed in less than 1 second after said article is subjected to aqueous storage at 50°

C. for 3 months and dried.

6. The article of claim 5, wherein

said polymeric layer comprises a polymer selected from the group consisting of (A) polyethylene, polypropylene, polystyrene, polyester, polycarbonates, silicone polymers, polyurethane, polyamides, polyimides, polyalkylacrylates, polyalkylmethacrylates, and fluorocarbon polymers;

(B) poly-2-hydroxylethylmethacrylate, polyhydroxylalkyl methacrylates, polyhydroxylalkyl acrylates, polyacrylic amides, polymethacrylic amides, polyvinyl alcohols, polyethylene oxide, and polyvinyl pyrrolidone;

(C) polylactic acid, polyglycolic acid, polyglycolide-co-lactides, polydioxanones, poly(glycolide-co-trimethylene carbonates), polyethylene carbonates, polyiminocarbonates, poly-β

-hydroxybutyrates, polyesteramides, polyorthoesters, polyanhydrides, and cyanoacrylates; and

(D) copolymers of members of (A), (B) and (C); and

said polyelectrolyte coating comprises a polyelectrolyte selected from the group consisting of polyethyleneimine, polyaminoalkyl methacrylate, polyvinylpyridine, polylysine, polyacrylic acid, polymethacrylic acid, polysulfonic acid, polyvinyl sulfate, polyacrylamido-2-methyl-1-propanesulfonic acid, and polystyrene sulfonic acid.

7. The article of claim 6, wherein said article is a microcarrier for cultering cells.

8. The article of claim 1, wherein a drop of water placed on said coating is absorbed in less than 1 second after 30 ultrasonic wash cycles with deionized water.

9. The article of claim 1, wherein a drop of water placed on said coating is absorbed in less than 2 seconds after 60 ultrasonic wash cycles with deionized water.

10. The article of claim 8, wherein

said polymeric layer comprises a polymer selected from the group consisting of (A) polyethylene, polypropylene, polystyrene, polyester, polycarbonates, silicone polymers, polyurethane, polyamides, polyimides, polyalkylacrylates, polyalkylmethacrylates, and fluorocarbon polymers;

(B) poly-2-hydroxylethylmethacrylate, polyhydroxylalkyl methacrylates, polyhydroxylalkyl acrylates, polyacrylic amides, polymethacrylic amides, polyvinyl alcohols, polyethylene oxide, and polyvinyl pyrrolidone;

(C) polylactic acid, polyglycolic acid, polyglycolide-co-lactides, polydioxanones, poly(glycolide-co-trimethylene carbonates), polyethylene carbonates, polyiminocarbonates, poly-β

-hydroxybutyrates, polyesteramides, polyorthoesters, polyanhydrides, and cyanoacrylates; and

(D) copolymers of members of (A), (B) and (C); and

said polyelectrolyte coating comprises a polyelectrolyte selected from the group consisting of polyethyleneimine, polyaminoalkyl methacrylate, polyvinylpyridine, polylysine, polyacrylic acid, polymethacrylic acid, polysulfonic acid, polyvinyl sulfate, polyacrylamido-2-methyl-1-propanesulfonic acid, and polystyrene sulfonic acid.

11. The article of claim 1, wherein

said polymeric layer comprises a polymer selected from the group consisting of (A) polyethylene, polypropylene, polystyrene, polyester, polycarbonates, silicone polymers, polyurethane, polyamides, polyimides, polyalkylacrylates, polyalkylmethacrylates, and fluorocarbon polymers;

(B) poly-2-hydroxylethylmethacrylate, polyhydroxylalkyl methacrylates, polyhydroxylalkyl acrylates, polyacrylic amides, polymethacrylic amides, polyvinyl alcohols, polyethylene oxide, and polyvinyl pyrrolidone;

(C) polylactic acid, polyglycolic acid, polyglycolide-co-lactides, polydioxanones, poly(glycolide-co-trimethylene carbonates), polyethylene carbonates, polyiminocarbonates, poly-β

-hydroxybutyrates, polyesteramides, polyorthoesters, polyanhydrides, and cyanoacrylates; and

(D) copolymers of members of (A), (B) and (C); and

said polyelectrolyte coating comprises a polyelectrolyte selected from the group consisting of polyethyleneimine, polyaminoalkyl methacrylate, polyvinylpyridine, polylysine, polyacrylic acid, polymethacrylic acid, polysulfonic acid, polyvinyl sulfate, polyacrylamido-2-methyl-1-propanesulfonic acid, and polystyrene sulfonic acid.

12. The article of claim 11, wherein said polymeric layer is selected from polyester, polypropylene, polyethylene, polystyrene, polymethylmethacrylate, polyglycolic acid, and polylactic acid;

and said polyelectrolyte coating comprises polyethyleneimine.

13. The article of claim 1, wherein said article is a matrix which retains solids, cells, or a target component.

14. The article of claim 1, wherein said article is a microcarrier for culturing cells.