Implantable passive bio-sensor

• US 5,704,352 A
• Filed: 11/22/1995
• Issued: 01/06/1998
• Est. Priority Date: 11/22/1995
• Status: Expired due to Term

• Current Assignee: Remon Medical Technologies Ltd. (Boston Scientific Corporation)
• Original Assignee: David S. Buckles, Gerald F. Tremblay
• Inventors: Tremblay, Gerald F., Buckles, David S.
• Primary Examiner(s): Bahr, Jennifer
• Assistant Examiner(s): HUANG, STEPHEN D
• Application Number:
  US08/562,093
• Time in Patent Office: 776 Days
• Field of Search: 128/630, 128/642, 128/748, 128/675, 128/673, 128/903, 128/899
• US Class Current: 600/300
• CPC Class Codes: A61B 2560/0219 of externally powered implanted units
• CPC Class Codes: A61B 5/0031 Implanted circuitry
• CPC Class Codes: A61B 5/01 Measuring temperature of body parts ; Diagnostic temperature sensing, e.g. for malignant or inflamed tissue clinical contact thermometers G01K13/20
• CPC Class Codes: A61B 5/031 Intracranial pressure
• CPC Class Codes: A61M 27/006 Cerebrospinal drainage; Accessories therefor, e.g. valves

Abstract

An implantable, passive bio-sensor (10) for monitoring internal physiological conditions of a patient is disclosed. The bio-sensor (10) includes at least one sensor or transducer (12) for monitoring a physiological condition of the patient and a passive transponder (14) that receives sensor signals from the sensor or sensors (12), digitizes the sensor signals, and transmits the digitized signals out of the patient'"'"'s body when subjected to an externally generated interrogation signal. In one embodiment, the bio-sensor (100) is incorporated into the sidewall of a shunt (102) used for treating hydrocephalus for non-invasively monitoring the operation of the shunt (102).

Claims

1. A bio-sensor for implantation in a patient, said bio-sensor comprising:

sensor means for sensing a physiological condition of the patient and for generating a sensor signal representative of the physiological condition; and

a transponder electrically coupled with said sensor means, said transponder including

processor means for implanatation in the patient and responsive to said sensor means for converting said sensor signal to a digital signal representative of the physiological condition without sending said sensor signal out of the patient'"'"'s body, and

transmitting means coupled with said processor means for transmitting said digital signal out of the patient'"'"'s body, said transmitting means including antenna means for receiving an interrogation signal generated from outside the patient and power converting means coupled with said antenna means for converting the interrogation signal to a power signal for energizing said processor means.

2. The bio-sensor as set forth in claim 1, said transmitting means further including modulating means coupled with said processor means and said antenna means for modulating said interrogation signal in accordance with said digital signal to create a modulated interrogation signal for transmitting said digital signal out of the patient.

3. The bio-sensor as set forth in claim 2, wherein said processor means, modulating means and power converting means are formed on an integrated circuit microprocessor chip.

4. The bio-sensor as set forth in claim 2, further including an interrogator positioned outside the patient'"'"'s body for energizing said processor means, said interrogator including

generating means for generating said interrogation signal, and

transmitting means coupled with said generating means for transmitting said interrogation signal to said transponder and for receiving said modulated interrogation signal from said transponder.

5. The bio-sensor as set forth in claim 4, said interrogator further including demodulating means coupled with said transmitting means for demodulating said modulated interrogation signal to retrieve said digital signal.

6. The bio-sensor as set forth in claim 1, said sensor means including a plurality of sensors, each of said sensors being operable for sensing a separate physiological condition of the patient and for generating a corresponding sensor signal representative of its respective physiological condition.

7. The bio-sensor as set forth in claim 6, said processor means including signal receiving means for receiving a plurality of sensor signals from said sensors.

8. The bio-sensor as set forth in claim 7, said processor means including memory means for storing said plurality of sensor signals and analyzing means for analyzing said plurality of sensor signals.

9. The bio-sensor as set forth in claim 1, wherein said processor means is programmable.

10. The bio-sensor as set forth in claim 9, said processor means including a programmable microprocessor.

11. The bio-sensor as set forth in claim 1 further including a shunt presenting a tubular sidewall and opposed ends, wherein said sensor means and said transponder are embedded in said shunt sidewall.

12. The bio-sensor as set forth in claim 1, said sensor means including a sensor selected from the group consisting of a pressure sensor, a temperature sensor, a pH sensor, a blood sugar sensor, a blood oxygen sensor, a motion sensor, a flow sensor, a velocity sensor, an acceleration sensor, a force sensor, a strain sensor, an acoustics sensor, a moisture sensor, an osmolarity sensor, a light sensor, a turbidity sensor, a radiation sensor, an electromagnetic field sensor, a chemical sensor, an ionic sensor, and an enzymatic sensor.

13. The bio-sensor as set forth in claim 1, said transponder further including means for transmitting an identification code identifying said transponder out of the patient'"'"'s body.

14. A bio-sensor for implantation in a patient, said bio-sensor comprising:

a shunt for draining fluid from a portion of a patient'"'"'s body; and

monitoring means coupled with said shunt for non-invasively monitoring said shunt, said monitoring means including

sensor means for sensing a physiological condition of the patient and for generating a sensor signal representative of the physiological condition; and

a transponder electrically coupled with said sensor means, said transponder including

processor means for implantation in the patient and responsive to said sensor means for converting said sensor signal to a digital signal representative of the physiological condition, and

transmitting means coupled with said processor means for transmitting said digital signal out of the patient'"'"'s body, said transmitting means including antenna means for receiving an interrogation signal generated from outside the patient and power converting means coupled with said antenna means for converting the interrogation signal to a power signal for energizing said processor means.

15. The bio-sensor as set forth in claim 14, said transmitting means further including modulating means coupled with said processor means and said antenna means for modulating said interrogation signal in accordance with said digital signal to create a modulated interrogation signal for transmitting said digital signal out of the patient.

16. The bio-sensor as set forth in claim 14, said sensor means including a sensor selected from the group consisting of a pressure sensor, a temperature sensor, a pH sensor, a blood sugar sensor, a blood oxygen sensor, a motion sensor, a flow sensor, a velocity sensor, an acceleration sensor, a force sensor, a strain sensor, an acoustics sensor, a moisture sensor, an osmolarity sensor, a light sensor, a turbidity sensor, a radiation sensor, an electromagnetic field sensor, a chemical sensor, an ionic sensor, and an enzymatic sensor.

17. The bio-sensor as set forth in claim 14, said shunt including a cerebrospinal fluid shunt for draining cerebrospinal fluid from the patient'"'"'s brain, said shunt presenting a tubular sidewall defining a fluid passageway, a ventricular end for placement in a ventricular cavity of the patient'"'"'s brain for delivering cerebrospinal fluid to said passageway and a distal end axially opposed from said ventricular end for placement out of the ventricular cavity for draining cerebrospinal fluid out of said passageway.

18. The bio-sensor as set forth in claim 17, said sensor means including a first pressure sensor positioned within said fluid passageway for sensing the pressure of the cerebrospinal fluid in said fluid passageway and for generating a first pressure signal representative of the pressure.

19. The bio-sensor as set forth in claim 18, wherein said first pressure sensor is coupled with said ventricular end for sensing the pressure of the cerebrospinal fluid entering said shunt, said monitoring means further including a second pressure sensor coupled with said distal end for sensing the pressure of the cerebrospinal fluid flowing from said shunt and for generating a second pressure signal representative of the pressure.

20. The bio-sensor as set forth in claim 19, said processor means including receiving means for receiving said first and second pressure signals from said first and second pressure sensors.

21. The bio-sensor as set forth in claim 20, said processor means including calculating means for calculating the flow of cerebrospinal fluid through said shunt in response to receipt of said first and second pressure signals by said receiving means.

22. The bio-sensor as set forth in claim 20, said processor means including a programmable microprocessor.

23. The bio-sensor as set forth in claim 14, further including an interrogator positioned outside the patient'"'"'s body for energizing said processor means, said interrogator including

generating means for generating said interrogation signal, and

transmitting means coupled with said generating means for transmitting said interrogation signal to said transponder and for receiving said modulated interrogation signal from said transponder.

24. The bio-sensor as set forth in claim 23, said interrogator further including demodulating means coupled with said transmitting means for demodulating said modulated interrogation signal to retrieve said digital signal.