Human drug delivery device for tinnitus

• US 5,713,847 A
• Filed: 02/06/1996
• Issued: 02/03/1998
• Est. Priority Date: 02/09/1994
• Status: Expired due to Term

• Current Assignee: University of Iowa Research Foundation
• Original Assignee: University of Iowa Research Foundation
• Inventors: McCulloch, Timothy M., Howard, Matthew A. III, Bauer, Carol A.
• Primary Examiner(s): Kamm, William E.
• Application Number:
  US08/597,348
• Time in Patent Office: 728 Days
• Field of Search: 604/21, 607/3, 607/55, 607/115, 607/116, 607/120, 607/124, 607/137, 128/642
• US Class Current: 604/21
• CPC Class Codes: A61B 18/148 having a short, rigid shaft for accessing the inner body transcutaneously, e.g. for neurosurgery or arthroscopy
• CPC Class Codes: A61B 2018/00434 Neural system
• CPC Class Codes: A61B 2018/00577 Ablation
• CPC Class Codes: A61B 2018/00839 Bioelectrical parameters, e.g. ECG, EEG
• CPC Class Codes: A61B 90/10 for stereotaxic surgery, e.g. frame-based stereotaxis
• CPC Class Codes: A61F 11/00 Methods or devices for treatment of the ears or hearing sense implantable prostheses that substitute or replace internal ear parts, e.g. ear-drums, A61F2/18; methods or devices to cause a change in the state of auditory consciousness A61M21/00; electrotherapy applying electrical stimulation of the auditory system, or circuits therefor A61N1/36; radiotherapy using optical stimulation of the auditory system A61N5/06; electro-acoustic hearing aids H04R25/00; Non-electric hearing aids; Methods or devices for enabling ear patients to achieve auditory perception through physiological senses other than hearing sense; Protective devices for the ears, carried on the body or in the hand headwear, e.g. caps or helmets, with means for protecting the ears A42B1/0188, A42B3/16
• CPC Class Codes: A61F 11/20 Ear surgery
• CPC Class Codes: A61F 5/0026 Anti-eating devices using electrical stimulation
• CPC Class Codes: A61M 2210/0693 Brain, cerebrum
• CPC Class Codes: A61M 27/006 Cerebrospinal drainage; Accessories therefor, e.g. valves
• CPC Class Codes: A61M 5/14276 specially adapted for implantation
• CPC Class Codes: A61M 5/1428 with manual pumping action
• CPC Class Codes: A61M 5/1723 using feedback of body parameters, e.g. blood-sugar, pressure measurement of body parameters A61B5/00
• CPC Class Codes: A61N 1/05 for implantation or insertion into the body, e.g. heart electrode A61N1/06 takes precedence
• CPC Class Codes: A61N 1/0529 Electrodes for brain stimulation
• CPC Class Codes: A61N 1/0531 Brain cortex electrodes
• CPC Class Codes: A61N 1/0539 Anchoring of brain electrode systems, e.g. within burr hole
• CPC Class Codes: A61N 1/0541 Cochlear electrodes
• CPC Class Codes: A61N 1/326 for promoting growth of cells, e.g. bone cells
• CPC Class Codes: A61N 1/36082 Cognitive or psychiatric applications, e.g. dementia or Alzheimer's disease
• CPC Class Codes: A61N 1/361 : Phantom sensations, e.g. tinnitus

Abstract

A neural prosthetic drug delivery apparatus for reducing or eliminating the effects of tinnitus. The apparatus includes a catheter which is inserted into the patient'"'"'s auditory cortex or thalamus. The catheter microinfuses drugs which suppress or eliminate abnormal neural activity into geometrically separate locations of the patient'"'"'s brain, thereby reducing or eliminating the effects of tinnitus. In one embodiment the apparatus includes a stimulation device for outputting processed electrical signals and an electrode having a plurality of electrical contacts which is arranged in a target zone of the patient'"'"'s brain. Each of the plurality of electrical contacts independently outputs electrical discharges in accordance with the electrical signals.

Claims

1. A neural therapeutic apparatus for treatment of a patient with tinnitus, comprising:

a drug reservoir-pump for containing and pumping a drug, wherein said drug is capable of reducing abnormal neural activity associated with tinnitus; and

a drug delivering catheter for arrangement in the patient'"'"'s auditory, cortex or thalamus, said drug delivering catheter operatively connected to said drug reservoir-pump, and said drug delivering catheter having a plurality of ports, each of said plurality of ports capable of outputting said drug to predetermined geometric locations within said one of the patient'"'"'s auditory, cortex and thalamus.

2. The neural therapeutic apparatus as claimed in claim 1, further comprising:

a stimulation device for outputting electrical signals; and

a stimulating and recording electrode arranged in said drug delivering catheter, said electrode having a plurality of electrical contacts electrically coupled to said stimulation device, and each of said plurality of electrical contacts outputting one or more electrical discharges in accordance with said electrical signals, wherein each of said electrical contacts is capable of receiving electrical discharges in said one of the patient'"'"'s auditory, cortex and thalamus, and wherein said electrical discharge output blocks abnormal neural activity and alleviates the symptoms of tinnitus.

3. The neural therapeutic apparatus as claimed in claim 1, wherein said drug capable of reducing abnormal neural activity comprises a neurotransmitter inhibitor.

4. The neural therapeutic apparatus as claimed in claim 1, wherein said drug capable of reducing abnormal neural activity comprises an anticonvulsant.

5. The neural therapeutic apparatus as claimed in claim 1, wherein said drug capable of reducing abnormal neural activity comprises dilantin or γ

-aminobutyric acid.

6. The neural therapeutic apparatus of claim 1, wherein said drug delivering catheter comprises silastic material.

7. The neural therapeutic apparatus of claim 1, wherein said drug delivering catheter has a cross-sectional shape which is substantially circular or substantially elliptical.

8. The neural therapeutic apparatus of claim 1, wherein said plurality of ports are arranged at discrete locations on said drug delivering catheter.

9. The neural therapeutic apparatus of claim 8, wherein each of said plurality of ports are substantially circular and are from about 10 micrometers to about 2 millimeters in diameter, and wherein said plurality of ports are spaced from about 6 micrometers to about 2 millimeters apart.

10. The neural therapeutic apparatus of claim 9, wherein the centers of each of said plurality of ports are separated by a distance in the range of from about 20 micrometers to about 2 millimeters.

11. A neural therapeutic apparatus for implantation in a target zone of a patient'"'"'s brain, comprising:

a reservoir-pump for containing a drug, said drug capable of reducing abnormal neural activity, associated with tinnitus;

a catheter for delivering said drug to the target zone of the patient'"'"'s brain, said catheter operably connected to said reservoir-pump, and comprising one or more stimulating and recording electrodes;

a stimulation device for outputting electrical signals to said one or more electrodes, said electrodes outputting electrical discharges in accordance with said electrical signals, wherein said outputted electrical discharges block abnormal neural activity; and

a recording device operably connected to said one or more electrodes, said recording device capable of recording electrophysiologic data received by said one or more electrodes, from said target zone of the patient'"'"'s brain.

12. The neural therapeutic apparatus of claim 11, wherein said catheter includes a plurality of ports, each of said plurality of ports capable of outputting said drug to a geometrically separate, predetermined location within said target zone of the patient'"'"'s brain.

13. The neural therapeutic apparatus of claim 11, wherein said electrode has a plurality of electrical contacts, each of said plurality of electrical contacts electrically coupled to said stimulation device, with each of said plurality of electrical contacts capable of outputting electrical discharges to said target zone of the patient'"'"'s brain, wherein each of said plurality, of electrical contacts is further capable of receiving electrical discharges for recording as electrophysiologic data from said target zone of the patient'"'"'s brain.

14. The neural therapeutic apparatus of claim 11, wherein said reservoir-pump includes a recharging valve, and wherein said recharging valve is externally accessible.

15. The neural therapeutic apparatus of claim 11, wherein said reservoir-pump is adapted for attachment to the patient'"'"'s head, and wherein said reservoir-pump is adjustable by a radio control means.

16. The neural therapeutic apparatus of claim 11, wherein said drug is selected from the group consisting of an anticonvulsant, a neurotransmitter and a local anesthetic.

17. A neural therapeutic drug delivery apparatus for implantation in a target zone of a patient'"'"'s brain, comprising:

means for delivering a drug to said target zone of the patient'"'"'s brain, said drug capable of reducing abnormal neural activity associated with tinnitus;

means for outputting electrical discharges to said target zone of the patient'"'"'s brain; and

means for receiving electrical discharges from said target zone of the patient'"'"'s brain.

18. The neural therapeutic drug delivery, apparatus of claim 17, wherein said means for outputting electrical discharges and said means for receiving electrical discharges comprise one or more stimulating and recording electrodes, and said means for delivering said drug comprises a catheter comprising one or more ports capable of outputting said drug to one or more predetermined, separate locations within said target zone of the patient'"'"'s brain.

19. The neural therapeutic drug delivery apparatus of claim 18, wherein said means for delivering said drug further comprises a radio-controlled pump connected to said catheter, and wherein said target zone is an auxiliary cortex or a medial geniculate nucleus of a thalamus.