Techniques for adjusting the locus of excitation of neural tissue in the spinal cord or brain

• US 5,713,922 A
• Filed: 04/25/1996
• Issued: 02/03/1998
• Est. Priority Date: 04/25/1996
• Status: Expired due to Term

• Current Assignee: Medtronic Incorporated (Medtronic Plc)
• Original Assignee: Medtronic Incorporated (Medtronic Plc)
• Inventors: King, Gary William
• Primary Examiner(s): Kamm, William E.
• Assistant Examiner(s): EVANISKO, GEORGE ROBERT
• Application Number:
  US08/637,361
• Time in Patent Office: 649 Days
• Field of Search: 607/2, 607/43, 607/45, 607/54, 607/58, 607/67, 607/72, 607/117, 607/118, 607/116, 607/139-141
• US Class Current: 607/2
• CPC Class Codes: A61N 1/0529 Electrodes for brain stimulation
• CPC Class Codes: A61N 1/0531 Brain cortex electrodes
• CPC Class Codes: A61N 1/0534 Electrodes for deep brain stimulation
• CPC Class Codes: A61N 1/0551 Spinal or peripheral nerve electrodes

Abstract

A method of controlling a volume of neural tissue stimulation with electrodes placed in the intraspinal tissue, on the surface of the brain or deep in the brain in which first, second and third electrodes are implanted in or adjacent to the desired neural tissue. Anode/cathode relationships are established between the electrodes and pulses are presented to the electrodes so that fibers or cell bodies in said neural tissue are activated. Amplitude and/or pulse width of the pulses are varied to steer the locus of cell body or axon activation.

Claims

1. A method of controlling for therapeutic purposes a volume of neural tissue stimulation of a predetermined portion of a brain of a patient, the method comprising the steps of:

placing a first electrode, a second electrode, and a third electrode at least near said predetermined portion of the brain;

establishing anode/cathode relationships between said first electrode and said second electrode and between said first electrode and said third electrode; and

presenting electrical pulses to each established anode/cathode relationship to cause a steerable locus of excitation of nerve fibers or cells of said brain;

whereby said nerve fibers or cells are activated in said predetermined portion of said brain.

2. A method, as claimed in claim 1, wherein said pulses overlap in time.

3. A method, as claimed in claim 1, further comprising the step of adjusting said electrical pulses whereby said volume of neural tissue stimulation is adjusted.

4. A method, as claimed in claim 1, wherein said pulses are independently variable in amplitude.

5. A method, as claimed in claim 1, wherein said pulses are variable in pulse width.

6. A method, as claimed in claim 1, wherein said first, second and third electrodes are placed in a generally planar configuration.

7. A method, as claimed in claim 1, wherein said first, second and third electrodes are placed generally along a common axis.

8. A method, as claimed in claim 1, wherein said predetermined portion is adjacent the central sulcus.

9. A method, as claimed in claim 1, wherein said predetermined portion is deep in the brain.

10. A method, as claimed in claim 1, wherein said predetermined portion is on the surface of said brain.

11. A method, as claimed in claim 1, wherein one or more of said electrodes are implanted in brain tissue, and others are in fluid spaces outside or inside the said brain tissue.

12. A method of controlling a volume of neural tissue stimulation of a predetermined portion of a brain of a patient. the method comprising the steps of:

placing a first electrode, a second electrode, and a third electrode at least near said predetermined portion of the brain;

establishing anode/cathode relationships between said first electrode and said second electrode and between said first electrode and said third electrode; and

presenting electrical pulses to each established anode/cathode relationship,

whereby nerve fibers or cells are activated in said predetermined portion of said brain and wherein said pulses are independently variable in amplitude.

13. A method, as claimed in claim 12, wherein said pulses are variable in pulse width.

14. A method, as claimed in claim 12, wherein said step of placing includes placing said first electrode, said second electrode, and said third electrode in a generally planar configuration.

15. A method, as claimed in claim 12, wherein said step of placing includes placing said first electrode, said second electrode, and said third electrode generally along a common axis.

16. A method, as claimed in claim 12, wherein said predetermined portion is adjacent the central sulcus.

17. A method, as claimed in claim 12, wherein said predetermined portion is deep in the brain.

18. A method, as claimed in claim 12, wherein said predetermined portion is on the surface of said brain.

19. A method, as claimed in claim 12, wherein said step of placing includes placing at least one of said electrodes in brain tissue, and includes placing other electrodes in fluid spaces outside or inside said brain tissue.

20. A method, as claimed in claim 12, further comprising the step of adjusting said electrical pulses whereby said volume of neural tissue stimulation is adjusted.

21. A method of controlling a volume of neural tissue stimulation of a predetermined portion of a brain of a patient, the method comprising the steps of:

placing a first electrode, a second electrode, and a third electrode at least near said predetermined portion of the brain;

establishing anode/cathode relationships between said first electrode and said second electrode and between said first electrode and said third electrode; and

presenting electrical pulses to each established anode/cathode relationship,

whereby nerve fibers or cells are activated in said predetermined portion of said brain and wherein said pulses are variable in pulse width.

22. A method, as claimed in claim 21, wherein said step of placing includes placing said first electrode, said second electrode, and said third electrode in a generally planar configuration.

23. A method, as claimed in claim 21, wherein said step of placing includes placing said first electrode, said second electrode, and said third electrode generally along a common axis.

24. A method, as claimed in claim 21, wherein said predetermined portion is adjacent the central sulcus.

25. A method, as claimed in claim 21, wherein said predetermined portion is deep in the brain.

26. A method, as claimed in claim 21, wherein said predetermined portion is on the surface of said brain.

27. A method, as claimed in claim 21, wherein said step of placing includes placing at least one of said electrodes in brain tissue, and includes placing other electrodes in fluid spaces outside or inside said brain tissue.

28. A method, as claimed in claim 21, further comprising the step of adjusting said electrical pulses whereby said volume of neural tissue stimulation is adjusted.

29. A method of controlling a volume of neural tissue stimulation of a predetermined portion of a brain of a patient, the method comprising the steps of:

placing a first electrode, a second electrode, and a third electrode at least near said predetermined portion of the brain;

establishing anode/cathode relationships between said first electrode and said second electrode and between said first electrode and said third electrode;

presenting electrical pulses to each established anode/cathode relationship

whereby nerve fibers or cells are activated in said predetermined portion of said brain and wherein said step of placing includes placing said first electrode, said second electrode, and said third electrode in a generally planar configuration.

30. A method of controlling a volume of neural tissue stimulation of a predetermined portion of a brain of a patient, the method comprising the steps of:

placing a first electrode, a second electrode, and a third electrode at least near said predetermined portion of the brain;

establishing anode/cathode relationships between said first electrode and said second electrode and between said first electrode and said third electrode; and

presenting electrical pulses to each established anode/cathode relationship,

whereby nerve fibers or cells are activated in said predetermined portion of said brain and wherein said step of placing includes placing said first electrode, said second electrode, and said third electrode generally along a common axis.

31. A method of controlling a volume of neural tissue stimulation of a predetermined portion of a brain of a patient. the method comprising the steps of:

placing a first electrode, a second electrode, and a third electrode at least near said predetermined portion of the brain;

establishing anode/cathode relationships between said first electrode and said second electrode and between said first electrode and said third electrode; and

presenting electrical pulses to each established anode/cathode relationship,

whereby nerve wherein said predetermined in said predetermined portion of said brain and wherein said predetermined portion is adjacent the central sulcus.

32. A method of controlling a volume of neural tissue stimulation of a predetermined portion of a brain of a patient. the method comprising the steps of:

placing a first electrode, a second electrode, and a third electrode at least near said predetermined portion of the brain;

establishing anode/cathode relationships between said first electrode and said second electrode and between said first electrode and said third electrode; and

presenting electrical pulses to each established anode/cathode relationship;

whereby nerve fibers or cells are activated in said predetermined portion of said brain and wherein said predetermined portion is deep in the brain.

33. A method of controlling a volume of neural tissue stimulation of a predetermined portion of a brain of a patient, the method comprising the steps of:

placing a first electrode, a second electrode, and a third electrode at least near said predetermined portion of the brain;

establishing anode/cathode relationships between said first electrode and said second electrode and between said first electrode and said third electrode; and

presenting electrical pulses to each established anode/cathode relationship.

whereby nerve fibers or cells are activated in said predetermined portion of said brain wherein said predetermined portion is on the surface of said brain.

34. A method of controlling a volume of neural tissue stimulation of a predetermined portion of a brain of a patient, the method comprising the steps of:

placing a first electrode, a second electrode, and a third electrode at least near said predetermined portion of the brain;

establishing anode/cathode relationships between said first electrode and said second electrode and between said first electrode and said third electrode; and

presenting electrical pulses to each established anode/cathode relationship,

whereby nerve fibers or cells are activated in said predetermined portion of said brain and wherein said step of placing includes placing at least one of said electrodes in brain tissue, and includes placing other electrodes in fluid spaces outside or inside said brain tissue.

35. A method of controlling a volume of neural tissue stimulation of a predetermined portion of a brain of a patient, the method comprising the steps of:

placing a first electrode, a second electrode, and a third electrode in a subdural area of said brain;

establishing anode/cathode relationships between said first electrode and said second electrode and between said first electrode and said third electrode; and

presenting electrical pulses to each established anode/cathode relationship to cause a steerable locus of excitation of nerve fibers or cells of said subdural area of said brain,

whereby said nerve fibers or cells are activated in said subdural area of said brain.

36. A method, as claimed in claim 35, wherein said pulses overlap at least partially in time.

37. A method, as claimed in claim 35, wherein said pulses are independently variable in amplitude.

38. A method, as claimed in claim 35, wherein said pulses are variable in pulse width.

39. A method, as claimed in claim 35, wherein said step of placing includes placing said first electrode, said second electrode, and said third electrode in a generally planar configuration.

40. A method, as claimed in claim 35, wherein said step of placing includes placing said first electrode, said second electrode, and said third electrode generally along a common axis.

41. A method, as claimed in claim 35, further comprising the step of adjusting said electrical pulses whereby said volume of neural tissue stimulation is adjusted.