Method of making a intralumenal drug eluting prosthesis

• US 5,725,567 A
• Filed: 04/27/1995
• Issued: 03/10/1998
• Est. Priority Date: 02/28/1990
• Status: Expired due to Term

• Current Assignee: Medtronic Incorporated (Medtronic Plc)
• Original Assignee: Medtronic Incorporated (Medtronic Plc)
• Inventors: Wolff, Rodney G., Hull, Vincent W.
• Primary Examiner(s): Brittingham, Debra S.
• Application Number:
  US08/430,526
• Time in Patent Office: 1,048 Days
• Field of Search: 623/1, 623/11, 623/12, 604/194, 604/195, 604/191, 600/36
• US Class Current: 623/1.42
• CPC Class Codes: A61F 2/852 Two or more distinct overlapping stents
• CPC Class Codes: A61F 2/90 characterised by a net-like or mesh-like structure
• CPC Class Codes: A61F 2/958 Inflatable balloons for placing stents or stent-grafts
• CPC Class Codes: A61F 2210/0076 multilayered, e.g. laminated structures
• CPC Class Codes: A61F 2250/0048 differing in mechanical expandability, e.g. in mechanical, self- or balloon expandability
• CPC Class Codes: A61F 2250/0063 Nested prosthetic parts
• CPC Class Codes: A61F 2250/0067 Means for introducing or releasing pharmaceutical products into the body
• CPC Class Codes: A61L 2300/416 Anti-neoplastic or anti-proliferative or anti-restenosis or anti-angiogenic agents, e.g. paclitaxel, sirolimus
• CPC Class Codes: A61L 31/16 Biologically active materials, e.g. therapeutic substances A61L31/047 takes precedence
• CPC Class Codes: A61M 31/002 Devices for releasing a drug at a continuous and controlled rate for a prolonged period of time artificial gland structures or devices A61F2/022; intra-uterine contraceptive devices A61F6/14; tampons for introducing into the vagina A61F13/20, A61L15/00; suppositories or bougies for intra-vaginal or intra-uterine application A61K9/02; physical forms of medicinal preparations for sustained or differential drug release A61K9/20, A61K9/50
• CPC Class Codes: D04C 1/02 made from particular materials
• CPC Class Codes: D10B 2509/06 Vascular grafts; stents

Abstract

A prosthesis for insertion into a lumen to limit restenosis of the lumen. The prosthesis carries restenosis-limiting drugs which elute after the device is positioned in the lumen.

Claims

1. A method for making a device for local intralumenal administration of drugs comprising:

(a) providing a plurality of a first, structural filament;

(b) providing a second, bioabsorbable polymeric filament having a drug compounded therein,

(c) weaving the first, structural filaments and the second, bioabsorbable polymeric filament into a tubular, open-ended body, said first and second filaments woven helically along a center line of the tubular body as a common axis and woven in opposing helical directions such that the tubular body is variable in radial diameter under axial movement of opposite ends of the body relative to each other and woven with at least a portion of the second, bioabsorbable filament exposed at an exterior surface of the tubular body.

2. The method of claim 1 wherein the plurality of first, structural support elements are made from a bioabsorbable polymer.

3. The method of claim 1 also comprising the steps of:

(a) providing a catheter; and

(b) loading the woven body into the catheter.

4. The method of claim 3 wherein the step of loading the woven body into the catheter includes loading the woven body at a distal end of the catheter.

5. The method of claim 3 wherein the step of loading the woven body into the catheter includes pulling the woven body longitudinally.

6. The method of claim 1 wherein the step of weaving the filaments in opposing helical directions includes forming an angle of 60 degrees to 90 degrees between the woven filaments.

7. The method of claim 1 wherein the step of weaving the filaments in opposing helical directions includes forming junctures between the filaments and then bonding the filaments together at the junctures to prevent the filaments from sliding relative to each other.

8. The method of claim 7 wherein the step of bonding the filaments includes the heating the filaments to a melting temperature.

9. The method of claim 1 wherein the step of weaving the filaments in opposing helical directions includes forming junctures between the filaments and then kinking the filaments at the junctures to prevent the filaments from sliding relative to each other.

10. The method of claim 9 wherein the step of kinking the filaments includes of heating the filaments.

11. The method of claim 1 wherein the second, bioabsorbable polymeric filament is provided as a high surface area multifilar filament comprised of a plurality of strands.

12. The method of claim 1 wherein the step of weaving the filaments includes forming an angle of 60 degrees to 90 degrees between the woven filaments.