Remote-dosing analyte concentration meter

• US 5,736,103 A
• Filed: 08/09/1996
• Issued: 04/07/1998
• Est. Priority Date: 08/09/1996
• Status: Expired due to Term

• Current Assignee: Lifescan Incorporated (Duv Holding Corporation)
• Original Assignee: Lifescan Incorporated (Duv Holding Corporation)
• Inventors: Pugh, Jerry Thomas
• Primary Examiner(s): Pyon, Harold Y.
• Application Number:
  US08/694,971
• Time in Patent Office: 606 Days
• Field of Search: 422/55, 422/56, 422/57, 422/58, 422/61, 422/68.1, 422/82.05, 422/100, 422/63, 422/101, 422/102, 422/104, 436/8, 436/16, 436/14, 436/18, 436/44, 128/633, 128/632, 128/770
• US Class Current: 422/68.1
• CPC Class Codes: B01L 3/5023 with a sample being transported to, and subsequently stored in an absorbent for analysis
• CPC Class Codes: G01N 21/78 producing a change of colour
• CPC Class Codes: Y10T 436/10 Composition for standardization, calibration, simulation, stabilization, preparation or preservation; processes of use in preparation for chemical testing
• CPC Class Codes: Y10T 436/104998 Glucose, ketone, nitrate standard or control
• CPC Class Codes: Y10T 436/106664 Blood serum or blood plasma standard or control
• CPC Class Codes: Y10T 436/110833 Utilizing a moving indicator strip or tape

Abstract

A meter is used in conjunction with a hollow, frustum-shaped disposable device to measure the concentration of an analyte in a sample of a biological fluid. The smaller end of the frustum has a porous membrane, to which a sample of the fluid may be applied. Preferably, a reagent in the membrane reacts with the analyte to cause a color change. The meter has a frustum-shaped distal section that mates with the device. The meter measures the color change and computes from the change the analyte concentration in the sample. The meter and disposable device permit remote dosing of the device, which minimizes the likelihood of cross-contamination between the user and the meter. Devices can be mounted on the meter and released from the meter without touching them, to further protect against contamination.

Claims

1. A meter for measuring a concentration of an analyte in a sample of biological fluid that is applied to a first surface of a porous membrane that contains a reagent, which reacts with the analyte to cause a change in reflectance of a second surface of the membrane, the membrane being attached to and substantially closing an end of a hollow frustum device, and the meter comprising

(a) a body having a frustum-shaped distal section for mating engagement with the device, the section tapering inwardly to an end that faces the second surface of the membrane,

(b) an optical system in the body to direct a beam of light out from the distal end and to accept light reflected back from the second surface of the membrane,

(c) means for measuring the light reflected back into the body both before and after the sample is applied to the membrane, and

(d) means for computing the analyte concentration in the fluid from the measured values of reflected light.

2. The meter of claim 1 in which the frustum has a substantially rectangular cross section.

3. The meter of claim 1 in which the frustum has a substantially circular cross section.

4. The meter of claim 1 in which the distal section further comprises a peripheral groove for engaging corresponding portions of the device.

5. The meter of claim 1 further comprising a display for depicting the computed analyte concentration.

6. The meter of claim 1, further comprising a push-button means for disengaging the device from the distal end of the meter.

7. A kit for measuring analyte concentration in biological fluids comprising, in combination, the meter of claim 1 and an elongated container for holding a plurality of the devices.

8. The kit of claim 7 in which the devices are arranged in a nested array along the length of the container.

9. The kit of claim 8 in which the distal section of the meter comprises a peripheral groove for engaging corresponding portions of the devices, whereby a meter can be prepared for sample application by engagingly inserting the distal section of the meter into a device and removing the device from the container.