Piperidine derivatives and process for their production

CAFC
  • US 5,750,703 A
  • Filed: 02/02/1995
  • Issued: 05/12/1998
  • Est. Priority Date: 06/24/1993
  • Status: Expired due to Term
First Claim
Patent Images

1. A process of preparing a piperidine derivative compound of the formula:

  • ##STR42## wherein R1 is hydrogen or hydroxy;

    R2 is hydrogen;

    or R1 and R2 taken together form a second bond between the carbon atoms bearing R1 and R2 ;

    R3 is --COOH or --COOR4 ;

    R4 has 1 to 6 carbon atoms;

    A, B, and D are the substituents of their aromatic rings, each of which may be different or the same, and are selected from the group consisting of hydrogen, halogens, alkyl, hydroxy, alkoxy, or other substituents,said process comprising;

    providing a substantially pure regioisomer of the following formula;

    ##STR43## converting the substantially pure regioisomer to the piperidine derivative compound with a piperidine compound of the formula;

    ##STR44## .

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