Membrane filter and a method of manufacturing the same as well as a membrane

• US 5,753,014 A
• Filed: 05/10/1996
• Issued: 05/19/1998
• Est. Priority Date: 11/12/1993
• Status: Expired due to Term

• Current Assignee: Cornelis Johannes Maria Van Rijn
• Original Assignee: Cornelis Johannes Maria Van Rijn
• Inventors: Van Rijn, Cornelis Johannes Maria
• Primary Examiner(s): SPITZER, ROBERT H
• Application Number:
  US08/646,351
• Time in Patent Office: 739 Days
• Field of Search: 96/8, 96/10-13, 55/524, 55/DIG. 5
• US Class Current: 96/12
• CPC Class Codes: B01D 2325/04 Characteristic thickness
• CPC Class Codes: B01D 39/1692 Other shaped material, e.g. perforated or porous sheets
• CPC Class Codes: B01D 67/0058 by selective elimination of components, e.g. by leaching
• CPC Class Codes: B01D 67/0062 by micromachining techniques, e.g. using masking and etching steps, photolithography
• CPC Class Codes: B01D 67/0072 by deposition from the gaseous phase, e.g. sputtering, CVD, PVD
• CPC Class Codes: B01D 69/02 characterised by their properties
• CPC Class Codes: B01D 69/10 Supported membranes; Membrane supports
• CPC Class Codes: B01D 69/108 Inorganic support material
• CPC Class Codes: B01D 69/12 Composite membranes; Ultra-thin membranes
• CPC Class Codes: B01D 69/1218 Layers having the same chemical composition, but different properties, e.g. pore size, molecular weight or porosity
• CPC Class Codes: B01D 71/02 Inorganic material
• CPC Class Codes: B01D 71/0213 Silicon
• CPC Class Codes: B01D 71/0215 Silicon carbide; Silicon nitride; Silicon oxycarbide
• CPC Class Codes: B01J 35/59 Membranes
• CPC Class Codes: G03F 7/12 Production of screen printing forms or similar printing forms, e.g. stencils
• CPC Class Codes: Y10S 55/05 Methods of making filter

Abstract

A membrane filter comprises a membrane provided with pores with a pore size between 5 nm and 50 μm. The membrane may easily and reliably be processed with use of silicon micromachining through depositing a relatively thin membrane layer on a support, by use of a suitable vapour deposition or spincoating technique, after which perforations are made in the thin membrane layer, for example by etching with aid of photo-lithography or an imprint technique. Such a membrane is very well applicable for the separation of biological cells. A membrane with a thickness smaller than the diameter of the perforations is in particular suited for the separation of vulnerable cells and may be used as a leucocyte filter or as a blood plasma separator of blood concentrates. A microfiltration membrane according to the invention may very well be applied as a support for the deposition of a separation layer for ultrafiltration, gas separation or catalysis.

Claims

1. Membrane filter comprising a membrane provided with pores of a size between 5 nm and 50 μ

m characterized in that said membrane comprises a substantially flat layer of substantially uniform thickness with a surface roughness which is considerably less than the pore size and in that the pores are etched in said substantially flat layer.

2. Membrane filter according to claim 1 characterized in that the membrane thickness is smaller than the average pore size and in that the membrane has a pore density which is larger than 1 million per square centimeter.

3. Membrane filter according to claim 1 characterized in that the membrane as well as the inner surface of the pores have a surface roughness less than 100 nm, and in that the membrane has a thickness which is smaller than the averages diameter of the pores.

4. Membrane filter according to claim 1 characterized in that the pores consist of etched perforations with relatively smooth edges and in that the membrane features a relatively sharp, well defined pore size distribution within a standard deviation of less than 3%.

5. Membrane filter according to claim 1 characterized in that the membrane is carried by a macroporous support with at least one opening at its surface which is spanned by the membrane.

6. Membrane filter according to claim 5 characterized in that the pores are provided within said at least one opening merely at a distance from its boundary and at a distance from its center.

7. Membrane filter according to claim 5 characterized in that the support is at least partially composed of a monocrystalline silicon wafer.

8. Membrane filter according to claim 5 characterized in that an intermediate layer is present:

between the membrane and the support, which intermediate layer provides for bonding enhancement and/or stress relief and comprises a member selected from the group consisting of borax, chromium, nickel, tantalum, aluminum, silicon oxide or phosporous pentoxide.

9. Membrane of the kind applied in the membrane filter according to claim 1.

10. Gas separation filter or an ultra filtration comprising a membrane as claimed in claim 9 characterized in that a gas separation layer respectively an ultra filtration layer is provided in or over the pores of said membrane.

11. Gas separation filter or an ultra filtration filter as claimed in claim 10 characterized in that the gas separation or ultra filtration layer has a thickness below 200 nm and comprises porous silicon.

12. Fractionating system for sorting particles on size comprising at least one membrane as claimed in claim 9.

13. Pump comprising a membrane as claimed in claim 9.

14. Membrane with a monocrystalline molecular sieve crystal obtained by means of the membrane filter according to claim 1.

15. Leuckocyt filter comprising a membrane filter as claimed in claim 1.

20. Method of manufacturing an ultra filtration filter or gas separation filter in which a silicon substrate is covered by a membrane according to claim 9, characterized in that an ultra filtration layer or a gas separation layer is deposited on said membrane, and in that the substrate is locally etched from its back side towards the membrane on top of it in order to expose the back side of the ultra filtration layer or gas separation layer respectively.

16. Method of manufacturing a membrane filter comprising a support which is covered by a membrane having pores of a size between 5 nm and 50 μ

m characterized in that a membrane layer is deposited on said support, in that the pores are etched in the membrane layer is provided with pores by means of a patterned auxiliary layer and in that at least one recess is etched from the backside and over the entire thickness of the support in order to expose the backside of the membrane layer.

17. Method according to claim 16 characterized in that the membrane layer is deposited by means of epitaxial growth, spin coating, vapour deposition or sputtering with a thickness between 20 μ

m and 5 nm, having a thickness uniformity below 10 nm and 100 nm respectively, and with a surface roughness which is considerably less than the pore size.

18. Method according to claim 16 characterized in that the auxiliary layer comprises a deposited masking layer which is patterned by means of a homogeneous mixture of particles added to it before its deposition.

19. Method according to claim 16 characterized in that the pores of the membrane layer are narrowed by coating with an additional layer, by means of spraying, lacquering, spin coating, vapour deposition or sputtering.

21. Method of manufacturing a membrane with ultra fine perforations characterized in that a first layer is deposited on a substrate which is provided with substantially parallel grooves which are deeper man wide, in that a sacrificial layer is conformally deposited over the surface, in that the sacrificial layer is provided with substantially parallel grooves which extend substantially traverse to the grooves in the first layer, in that a second layer is deposited over the entire surface covering the sacrificial layer and filling the grooves, in that the second layer is etched back until the lateral parts of the sacrificial layer are exposed, in that the exposed parts of the sacrificial layer are removed by etching and in that the substrate is etched through the realised openings in the sacrificial layer.