Single high dose fluoroquinolone treatment

• US 5,756,506 A
• Filed: 05/27/1997
• Issued: 05/26/1998
• Est. Priority Date: 06/27/1995
• Status: Expired due to Term

• Current Assignee: Bayer Healthcare LLC (Bayer AG)
• Original Assignee: Bayer Corporation (Bayer AG)
• Inventors: Ewert, Kathleen M., Copeland, Dennis D., Wollen, Terry S.
• Primary Examiner(s): Jarvis, William R. A.
• Application Number:
  US08/863,384
• Time in Patent Office: 364 Days
• Field of Search: 514/254, 514/230.2
• US Class Current: 514/254.11
• CPC Class Codes: A61K 31/496 Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
• CPC Class Codes: A61P 11/00 Drugs for disorders of the respiratory system
• CPC Class Codes: A61P 31/04 Antibacterial agents

Abstract

The present invention relates to treatment of bacterial infections in animals with fluoroquinolones. More specifically, the present invention relates to the use of fluoroqunolones in a single high dose to replace multiple lower doses.

Claims

1. A process for treating a bacterial infection in an animal in need thereof comprising administering to said animal a pharmaceutically effective composition comprising a fluoroquinolone, an ester, or a salt thereof in one high dose, single treatment.

2. A composition of claim 1 wherein the fluoroquinolone is selected from the group consisting of amifloxacin, benofloxacin, danofloxacin, difloxacin, enrofloxacin, flerofloxacin, fleroxacin, lomefloxacin, marbofloxacin, norfloxacin, ofloxacin, perfloxacin, rufloxacin, sarafloxacin, and temafloxacin.

3. The composition of claim 2 wherein the fluoroquinolone is enrofloxacin.

4. The process of claim 1, wherein the bacterial infection is bovine respiratory disease.

5. The process of claim 4 wherein the bovine respiratory disease is caused by Pasteurella, haemolytica or Pasteurella multocida.

6. The process of claim 1, wherein the bacterial infection is swine pneumonia.

7. The process of claim 6 wherein the swine pneumonia is caused by Actinobacillius pleuropneumonia.