Apparatus and method for activating photoactive agents

• US 5,762,867 A
• Filed: 09/01/1994
• Issued: 06/09/1998
• Est. Priority Date: 09/01/1994
• Status: Expired due to Term

• Current Assignee: Fenwal Incorporated (Fresenius SE & Co. KGaA)
• Original Assignee: Baxter International Inc.
• Inventors: D'Silva, Edmund D.
• Primary Examiner(s): Warden, Robert J.
• Assistant Examiner(s): Dawson, Elizabeth
• Application Number:
  US08/299,398
• Time in Patent Office: 1,377 Days
• Field of Search: 422/186, 422/23, 422/44, 250/455.11, 362/800, 362/373, 362/294, 435/2, 313/12, 313/23, 313/28, 313/32, 313/35, 313/36, 313/40, 604/4, 604/20
• US Class Current: 422/44
• CPC Class Codes: A61M 1/3616 Batch-type treatment
• CPC Class Codes: A61M 1/3681 by irradiation
• CPC Class Codes: A61M 1/3683 using photoactive agents
• CPC Class Codes: A61N 2005/0652 Arrays of diodes

Abstract

The present invention provides improved methods and apparatus for irradiating a product with light of a specific wavelength to activate the photoactive agent that is contained therein. To this end, in an embodiment, a device is provided that comprises a source of radiation including a plurality of light emitting diodes. Each light emitting diode includes a body portion through which radiation is transmitted. The body of the diode is surrounded by a fluid. In this regard, a first housing is provided that includes an interior that contains the light emitting diodes and a fluid. The housing includes a transparent window for allowing radiation generated by the light emitting diodes to flow through the window and irradiate a product that is in juxtaposition to the window.

Claims

1. A device for irradiating a product with light of a specific wavelength, the device comprising:

a source of radiation including a plurality of light emitting diodes, the light emitting diodes including a body portion through which radiation is transmitted, the body portion surrounded by a fluid;

a first housing enclosing the light emitting diodes and the fluid thereof, the first housing including a transparent window on an exterior wall of the first housing allowing radiation to flow through the transparent window and to irradiate the product in juxtaposition to the transparent window of the first housing; and

a body defining an interior that supports the first housing wherein an opening in the body allows the product to be placed in juxtaposition to the transparent window of the first housing removed from the body.

2. The device of claim 1 further comprising:

a second housing enclosing a second plurality of light emitting diodes, the second housing including a transparent window wherein the second housing is remotely situated such that the product is between the first housing and the second housing.

3. The device of claim 2 wherein the first housing and the second housing are located in planes that are substantially parallel to each other.

4. The device of claim 1 wherein the housing includes an inlet allowing fluid to flow into the interior and an outlet allowing fluid to flow out of the interior.

5. The device of claim 4 wherein the inlet and the outlet are connected to fluid conduits and a pump is provided to pump fluid through a first fluid conduit into the inlet.

6. The device of claim 4 further comprising:

means for cooling fluid before it enters the fluid inlet.

7. The device of claim 1 wherein the fluid is chosen from the group consisting of:

distilled water;

propylene glycol containing fluids; and

oil based fluids.

8. A system for irradiating a container including a product that includes a photoactive agent, the system comprising:

a housing including an interior receiving the container;

a first and second photo diode device on each side of the housing, each photo diode device including a body defining a chamber that includes a plurality of photo diodes generating radiation of a specific wavelength, the chamber including a fluid therein to cool the photo diodes, the first and second photo diode devices located in planes that are substantially parallel to each other and defining a space therebetween in the interior to receive the container wherein the housing includes an opening allowing the container to be placed within the space and removed therefrom.

9. The system of claim 8 wherein the first photodiode device defines a surface for supporting the container.

10. The system of claim 8 further comprising:

means for cooling the fluid.

11. The system of claim 8 wherein each photodiode device includes a fluid inlet and a fluid outlet.

12. The device of claim 8 wherein the fluid is chosen from the group consisting of:

distilled water;

propylene glycol containing fluids; and

oil based fluids.

13. A system for irradiating a container including a product that includes a photoactive agent, the system comprising:

a housing including an interior receiving the container; and

a photo diode device including a first body defining a chamber that includes a plurality of photo diodes generating radiation of a specific wavelength, the chamber including a fluid therein cooling the photo diodes, the first body including a transparent window that supports the container when it is placed in the interior of the housing wherein the photo diode device is incorporated into the housing.

14. The system of claim 13 further comprising:

a second body enclosing a second plurality of light emitting diodes, the second body including a transparent window.

15. The system of claim 14 wherein the first body and the second body are arranged substantially parallel to each other.

16. The system of claim 13 wherein the first body includes an inlet allowing the fluid to flow into the interior and an outlet allowing the fluid to flow out of the interior.

17. The system of claim 16 wherein the inlet and the outlet are connected to fluid conduits and a pump is provided to pump the fluid through a first fluid conduit into the inlet.

18. The system of claim 16 further comprising:

means for cooling fluid before it enters a fluid inlet.

19. The system of claim 16 wherein the fluid is chosen from the group consisting of:

distilled water;

propylene glycol containing fluids; and

oil based fluids.