Apparatus and method for non-invasive blood analyte measurement

• US 5,771,891 A
• Filed: 10/28/1996
• Issued: 06/30/1998
• Est. Priority Date: 05/10/1995
• Status: Expired due to Fees

• Current Assignee: Shai N. Gozani
• Original Assignee: Shai N. Gozani
• Inventors: Gozani, Shai N.
• Primary Examiner(s): Nasser, Robert L.
• Application Number:
  US08/738,183
• Time in Patent Office: 610 Days
• Field of Search: 128/635, 128/630, 128/632, 128/637, 128/741, 128/633
• US Class Current: 600/347
• CPC Class Codes: A61B 5/05 Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves impedance plethysmography A61B5/0295; measuring movement of the entire body or parts thereof A61B5/11; detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof A61B5/24
• CPC Class Codes: A61B 5/14532 for measuring glucose, e.g. by tissue impedance measurement
• CPC Class Codes: A61B 5/14546 for measuring analytes not otherwise provided for, e.g. ions, cytochromes
• CPC Class Codes: A61B 5/24 Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
• CPC Class Codes: A61B 5/4041 Evaluating nerves condition
• CPC Class Codes: A61B 5/681 Wristwatch-type devices

Abstract

A non-invasive blood analyte concentration monitor. The monitor includes a stimulator applying a stimulus to an endogenous tissue responsive to the stimulus and a detector for detecting a response of an endogenous tissue to the stimulus. Also provided is a correlator which correlates the detected response of the endogenous tissue to an analyte concentration. In one embodiment, the monitored blood analyte is glucose.

Claims

1. Apparatus comprising:

a stimulator adapted for applying an electrical or magnetic stimulus to an endogenous tissue responsive to said stimulus;

a detector adapted for detecting a response of an endogenous tissue to said stimulus;

a correlator adapted for correlating said detected response of said endogenous tissue to a quantitive measure of an analyte concentration; and

an indicator adapted for indicating said quantitative measure of said analyte concentration in response to said correlation by said correlator.

2. The apparatus recited in claim 1 wherein said analyte is a physiological analyte.

3. The apparatus recited in claim 1 wherein said analyte is a non-physiological analyte.

4. The apparatus recited in claim 1 wherein said stimulator is adapted for applying said stimulus to a first endogenous tissue and said detector is adapted for detecting a response of a second endogenous tissue to said stimulus.

5. The apparatus recited in claim 1 wherein said stimulator is adapted for applying said stimulus to a first endogenous tissue and said detector is adapted for detecting a response of said first endogenous tissue to said stimulus.

6. The apparatus recited in claim 1 further comprising an occluding mechanism for temporarily obstructing a flow of blood to said stimulated endogenous tissue or to said detected endogenous tissue.

7. The apparatus recited in claim 1 further comprising an output device adapted for providing an indication of said analyte concentration.

8. The apparatus recited in claim 7 wherein said output device comprises a visual display.

9. The apparatus recited in claim 7 wherein said output device comprises a speaker providing an audible indication of said analyte concentration.

10. The apparatus recited in claim 1 wherein said stimulus is an electrical stimulus and said stimulator comprises a pair of electrodes adapted for applying an electrical pulse to said stimulated endogenous tissue.

11. The apparatus recited in claim 10 wherein said electrical pulse is a current pulse.

12. The apparatus recited in claim 10 wherein said electrical pulse is a voltage pulse.

13. The apparatus recited in claim 10 wherein said pair of stimulator electrodes are adapted for positioning adjacent to a stimulated region of said first endogenous tissue.

14. The apparatus recited in claim 13 wherein said pair of stimulator electrodes are housed in a cuff.

15. The apparatus recited in claim 14 wherein said stimulator further comprises a temperature sensor housed in said cuff.

16. The apparatus recited in claim 13 wherein said response of said endogenous tissue to said stimulus is an electrical response signal and said detector comprises an electrode responsive to said electrical response signal.

17. The apparatus recited in claim 16 wherein said detector is adapted for positioning adjacent to a second region of said responsive endogenous tissue.

18. A method for determining a concentration of an analyte, comprising the steps of:

stimulating an endogenous tissue with an electrical or magnetic stimulus;

detecting a response of an endogenous tissue to said stimulus;

correlating said response to a quantitative measure of said analyte concentration; and

indicating said quantitative measure of a said analyte concentration in response to said correlation.

19. The method recited in claim 18 wherein said stimulating step comprises the step of stimulating a first endogenous tissue with said stimulus and said detecting step comprises the step of detecting a response of a second endogenous tissue to said stimulus.

20. The method recited in claim 18 wherein said stimulating step comprises the step of stimulating a first endogenous tissue with said stimulus and said detecting step comprises the step of detecting a response of said first endogenous tissue to said stimulus.

21. The method recited in claim 18 wherein said analyte is a physiological analyte.

22. The method recited in claim 18 wherein said analyte is a non-physiological analyte.

23. The method recited in claim 18 further comprising the step of temporarily occluding said stimulated endogenous tissue to obstruct a flow of blood to said stimulated tissue or to said endogenous tissue.

24. The method recited in claim 18 further comprising the step of visually displaying said analyte concentration.

25. The method recited in claim 18 further comprising the step of audibly indicating said analyte concentration.

26. The method recited in claim 18 further comprising the step of transmitting said analyte concentration to a remote location.

27. The method recited in claim 18 further comprising the step of storing said analyte concentration in a memory.

28. The method recited in claim 18 further comprising the step of repeating said stimulating, detecting and correlating steps to provide a plurality of indications of said analyte concentration and processing said plurality of indications of said analyte concentration.

29. The method recited in claim 18 further comprising the step of selecting a strength of said stimulus by repeating said stimulating, detecting and correlating steps with different strengths of said stimulus to determine a stimulus strength evoking a response by said detected endogenous tissue having a magnitude that is a predetermined fraction of a maximum response magnitude.

30. The method recited in claim 29 wherein said predetermined fraction of said maximum response magnitude is fifty percent.