Microcapsules of the multi-core structure containing natural carotenoid

• US 5,780,056 A
• Filed: 09/17/1996
• Issued: 07/14/1998
• Est. Priority Date: 05/10/1996
• Status: Expired due to Term

• Current Assignee: Lion Corporation
• Original Assignee: Lion Corporation
• Inventors: Yasue, Ryoji, Akamatsu, Taku, Kiyama, Kentaro, Hara, Noboru
• Primary Examiner(s): Page, Thurman K.
• Assistant Examiner(s): Benston, Jr., William E.
• Application Number:
  US08/714,266
• Time in Patent Office: 665 Days
• Field of Search: 426/93, 424/489, 424/464, 424/488, 424/479, 424/492, 424/486, 424/468, 424/471
• US Class Current: 424/464
• CPC Class Codes: A23L 5/44 using carotenoids or xanthophylls
• CPC Class Codes: A61K 9/1658 Proteins, e.g. albumin, gelatin
• CPC Class Codes: A61K 9/2077 Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets

Abstract

In a microcapsule of the multi-core structure comprising a plurality of particles which are made of a core material comprising natural carotenoid and an edible oil, and a wall which is made of a coating material based on gelatin, the particles have a mean particle size of 0.01-5 μm, the gelatin has a jelly strength of at least 100 blooms, and the microcapsule has a water content of up to 10% by weight. The microcapsule has a strength enough to protect natural carotenoid from oxidation and deterioration for a long time and to withstand tableting pressure.

Claims

1. A microcapsule of multi-core structure comprising a plurality of particles which are made of a core material comprising natural carotenoid and an edible oil, and a wall which is made of a coating material based on gelatin, wherein said particles have a mean particle size of 0.01 to 5 μ

m, said gelatin has a jelly strength of at least 100 blooms, and said microcapsule has a water content of up to 10% by weight based on the weight of said microcapsule.

2. The microcapsule of claim 1 which is microencapsulated by a spray cooling or curing-in-liquid technique.

3. The microcapsule of claim 1 wherein said gelatin has a jelly strength of at least 150 blooms.

4. The microcapsule of claim 1 which has a water content of up to 7% by weight based on the weight of said microcapsule.

5. The microcapsule of claim 1 wherein said particles have a mean particle size of 0.01 to 1 μ

m.

6. The microcapsule of claim 1 wherein said gelatin has a jelly strength of at least 150 blooms, said microcapsule has a water content of up to 7% by weight based on the weight of said microcapsule, and said particles have a mean particle size of 0.01 to 1 μ

m.

7. The microcapsule of claim 5 which is microencapsulated by a spray cooling or curing-in-liquid technique.

8. The microcapsule of claim 6 wherein said core material contains natural carotenoid and the edible oil in a weight ratio between 20:

80 and 50;

50.

9. The microcapsule of claim 6 wherein said particles have a mean core particle size and said microcapsule has a mean microcapsule particle size, the ratio of the core particle size to the microcapsule particle size being up to 1/50.

10. The microcapsule of claim 6 wherein said particles have a mean core particle size and said microcapsule has a mean microcapsule particle size, the ratio of the core particle size to the microcapsule particle size being up to 1/100.

11. The microcapsule of claim 6 which has a mean particle size of 50 to 3,000 μ

m.

12. The microcapsule of claim 6 which has a mean particle size of 100 to 2,000 μ

m.

13. The microcapsule of claim 1 which is prepared by a method comprising the steps of forming particles from the core material, microencapsulating the particles with the coating material, and drying the resulting microcapsule.

14. The microcapsule of claim 13 wherein the particle forming step includes phase inversion emulsification.

15. The microcapsule of claim 13 wherein the microencapsulation step includes spray cooling or curing-in-liquid.

16. The microcapsule of claim 13 wherein the drying step includes vacuum drying, through flow drying or fluidized bed drying.

17. The microcapsule as in any one of claims 1 to 16 wherein the natural carotenoid comprises palm oil carotenoid.

18. A tablet comprising microcapsules as set forth in claim 1.

19. An additive agent for foods comprising microcapsules as set forth in claim 1.

20. An additive agent for pharmaceuticals comprising microcapsules as set forth in claim 1.

21. A tablet comprising microcapsules as set forth in claim 1 and a vehicle.

22. The tablet according to claim 21, wherein said vehicle is selected from a group consisting of lactose, magnesium stearate, corn starch and saccharide ester.

23. The tablet according to claim 21, wherein said tablet contains 0.1 to 30% by weight of microcapsules.

24. The tablet according to claim 23, wherein said tablet contains 1 to 20% by weight of microcapsules.