Low energy pacing pulse waveform for implantable pacemaker

• US 5,782,880 A
• Filed: 04/23/1996
• Issued: 07/21/1998
• Est. Priority Date: 04/23/1996
• Status: Expired due to Term

• Current Assignee: Medtronic Incorporated (Medtronic Plc)
• Original Assignee: Medtronic Incorporated (Medtronic Plc)
• Inventors: Lahtinen, Stuart P., Anderson, Russell E.
• Primary Examiner(s): Kamm, William E.
• Assistant Examiner(s): EVANISKO, GEORGE ROBERT
• Application Number:
  US08/636,455
• Time in Patent Office: 819 Days
• Field of Search: 607/2, 607/5, 607/7, 607/9, 607/11, 607/68, 607/70, 607/74, 607/72
• US Class Current: 607/9
• CPC Class Codes: A61N 1/362 Heart stimulators heart defibrillators A61N1/39
• CPC Class Codes: A61N 1/37 Monitoring; Protecting
• CPC Class Codes: A61N 1/3956 Implantable devices for applying electric shocks to the heart, e.g. for cardioversion

Abstract

A tissue electrical stimulator and electrical pulse waveform are described. The stimulator or pulse generator may deliver the pules preferably through an endocardial electrode to pace a heart but could be used for other tissue such as nerves or to deliver defibrillation pulses through other means. A preferred circuit is described employing timing of a gate voltage level on an output transistor for the discharge capacitor(s) of the pulse generator. The waveform has a leading edge starting above zero volts and ramps upward for an initial fraction until a saturation voltage is reached and then ramps downward.

Claims

1. In an implantable pulse generator for providing cardiac pacing pulses through a discharge path including implantable pacing electrodes coupled to a patient'"'"'s heart in response to a pacing pulse trigger signal defining a predetermined pacing pulse interval, an improved pacing output circuit for reduced energy expenditure comprising:

an output capacitor adapted to be charged in a charge path and discharged in said discharge path;

charging circuit means for charging said output capacitor to a predetermined peak voltage level through said charge path; and

discharge circuit means operable in response to said pacing pulse trigger signal for controllably discharging said output capacitor in said discharge path and providing a pacing pulse output voltage across said implantable pacing electrodes commencing at an initial pulse voltage level less than said predetermined peak voltage level and greater than zero and increasing over an initial fraction of said pacing pulse interval to an intermediate pulse voltage level and thereafter exponentially decreasing in voltage amplitude during a remaining fraction of said pulse interval until a terminal end thereof, whereby pacing pulse energy delivered across said pacing electrodes is decreased and a residual charge of said output capacitor at the end of the pacing pulse interval is increased by restraining the discharge of said output capacitor during said initial fraction of said pacing pulse interval.

2. The implantable pulse generator of claim 1 wherein said initial pulse voltage level is in the range of approximately 10% to 50% of the predetermined peak voltage level.

3. The implantable pulse generator of claim 2 wherein said intermediate pulse voltage level corresponds to an exponential discharge level of said output capacitor reached during its discharge in the initial fraction of the pacing pulse interval.

4. The implantable pulse generator of claim 3 wherein said exponential decreasing pacing pulse output voltage corresponds to the exponential discharge of said output capacitor through an impedance across said pacing electrodes.

5. The implantable pulse generator of claim 1 wherein said intermediate pulse voltage level corresponds to a linear discharge level of said output capacitor reached during its discharge in the initial fraction of the pacing pulse interval.

6. The implantable pulse generator of claim 5 wherein a linearly decreasing pacing pulse output voltage corresponds to the linear discharge of said output capacitor through the impedance across said pacing electrodes.

7. In an implantable pulse generator for providing cardiac pacing pulses through a discharge path including an implantable pacing electrode coupled to a patient'"'"'s heart in response to a pacing pulse trigger signal defining a predetermined pacing pulse interval, an improved pacing output circuit for reduced energy expenditure comprising:

output capacitor means adapted to be charged in a charge path and discharged in said discharge path;

charging circuit means for charging said output capacitor means to a predetermined peak voltage level through said charge path;

an output circuit means having a conduction path in said discharge path coupled to said output capacitor and having a control gate; and

discharge voltage control circuit means operable in response to said pulse trigger signal and coupled to said control gate for providing a variable gate voltage to render said conduction path of said output circuit means conductive for controllably discharging said output capacitor means in said discharge path and providing a pacing pulse output voltage across said implantable pacing electrode(s) commencing at an initial pacing pulse voltage level less than said predetermined peak voltage level and greater than zero and increasing over an initial fraction of said pacing pulse interval to an intermediate pacing pulse voltage level and thereafter decreasing exponentially in voltage amplitude during a remaining fraction of said pulse interval until a terminal end thereof, whereby pacing pulse energy delivered across said pacing electrodes is decreased and a residual charge of said output capacitor at the end of the pacing pulse interval is increased by restraining the discharge of said output capacitor during said initial fraction of said pacing pulse interval.

8. The implantable pulse generator of claim 7 wherein said discharge voltage control circuit means further comprises:

gate voltage control means for providing an increasing gate voltage to said gate during said initial fraction rendering said conduction path of said output transistor conductive in a linear operating region for discharging said output capacitor in said discharge path at an increasing rate and providing said pacing pulse output voltage commencing from said initial pacing pulse voltage level until the increasing gate voltage renders said conduction path of said output transistor conductive in saturation for said remaining fraction of said pacing pulse interval, thereby providing said pacing pulse output voltage with an increasing voltage over said initial fraction and an exponentially decreasing voltage over said remaining fraction of said pacing pulse interval.

9. The pacing output pulse circuit of claim 8, wherein said gate voltage control means further comprises:

a diode circuit coupled to said gate for applying a fixed gate voltage to said gate for initially rendering said control circuit conductive in said linear operating region and providing said initial pacing pulse voltage level in response to said trigger pulse; and

a capacitive charging circuit coupled with said diode circuit and said gate and responsive to said trigger pulse for providing an increasing gate voltage as said variable control signal over said first fraction of said pacing pulse interval until said capacitive charging circuit is charged to a saturation gate voltage level, whereby said transistor is conductive in saturation.

10. The pacing output circuit of claim 7, wherein:

said output transistor further comprises a field effect transistor having said gate and a source-drain conduction path coupled in electrical series with said output capacitor and said pacing electrodes; and

said discharge voltage control circuit means is responsive to said trigger signal for providing a variable gate voltage to said gate over said initial fraction for operating said field effect transistor in a generally linearly increasing conduction range and for providing a fixed gate voltage to said gate over said subsequent fraction for operating said field effect transistor at saturation to allow exponential discharge of said output capacitor charge voltage therethrough.

11. The pacing output pulse circuit of claim 10, wherein said gate voltage control means further comprises:

a diode circuit coupled to said field effect transistor gate for applying a fixed gate voltage to said gate for initially rendering said field effect transistor conductive in said linear operating region and providing said initial pacing pulse voltage level in response to said trigger pulse; and

a capacitive charging circuit coupled with said diode circuit and said field effect transistor gate and responsive to said trigger pulse for providing an increasing gate voltage as said variable control signal over said first fraction of said pacing pulse interval until said capacitive charging circuit is charged to a saturation gate voltage level, whereby said field effect transistor is conductive in saturation.

12. The implantable pulse generator of claim 7 wherein said initial pacing pulse voltage level is in a range of approximately 10% to 50% of the predetermined peak voltage level.

13. The implantable pulse generator of claim 12 wherein said intermediate pacing pulse voltage level corresponds to a linear discharge level of said output capacitor reached during its discharge in the initial fraction of the pacing pulse interval.

14. The implantable pulse generator of claim 13 wherein said linear discharge of said pacing pulse output voltage is the linear discharge of said output capacitor through the transistor conduction path and an impendance across said pacing electrodes.

15. The implantable pulse generator of claim 7 wherein said intermediate pacing pulse voltage level corresponds to an linear discharge level of said output capacitor reached during its discharge in the initial fraction of the pacing pulse interval.

16. The implantable pulse generator of claim 15 wherein said linear discharge of said pacing pulse output voltage is the linear discharge of said output capacitor through the transistor conduction path and an impedance across said pacing electrodes.

17. In an implantable pulse generator for providing cardiac pacing pulses through implantable pacing electrodes to a patient'"'"'s heart and across an electrode-tissue interface and impedance of a discharge path through the patient'"'"'s heart in response to a pacing pulse trigger signal having a predetermined pulse width, an improved pacing output circuit for reducing energy expenditure comprising:

an output capacitor adapted to be charged in a charge path and discharged in said discharge path to provide said pacing pulse over said pulse width;

discharge switch means having a conduction path in a discharge circuit with said output capacitor and said pacing electrodes having an open state for blocking discharge current flow and an variable closed state for allowing variable current flow in dependence on a switch control signal;

charge circuit means for charging said output capacitor to a predetermined charge voltage level while said discharge switch means is in said open state; and

discharge circuit means operable in response to said pacing pulse trigger signal for providing a variable control signal to said discharge switch means for partially closing said discharge switch means and discharging said output capacitor at a progressively increasing voltage commencing from an initial pacing pulse voltage level less than said predetermined charge voltage level and greater than zero over an initial fraction of said pacing pulse interval until said discharge switch means is fully closed and thereafter allowing exponential discharge of said output capacitor voltage for a remaining fraction of said pacing pulse interval through said discharge switch.

18. The pacing output pulse circuit of claim 17, wherein said discharge switch means is a field effect transistor having a gate and a source-drain path providing said conduction path, and said discharge circuit means comprises:

gate voltage control means for providing a variable gate voltage to said gate over said first fraction for operating said field effect transistor in a generally linearly increasing conduction range and for providing a fixed gate voltage to said gate over said second fraction for operating said field effect transistor in saturation to allow exponential discharge of said output capacitor charge voltage therethrough.

19. The pacing output pulse circuit of claim 18, wherein said gate voltage control means further comprises:

a diode circuit coupled to said field effect transistor gate for applying a fixed gate voltage to said gate for initially rendering said field effect transistor conductive in said linear operating region and providing said initial pacing pulse voltage level in response to said trigger pulse; and

a capacitive charging circuit coupled with said diode circuit and said field effect transistor gate and responsive to said trigger pulse for providing an increasing gate voltage as said variable control signal over said first fraction of said pacing pulse interval until said capacitive charging circuit is charged to a saturation gate voltage level, whereby said field effect transistor is conductive in saturation.

20. The implantable pulse generator of claim 17 wherein said discharge switch means is an output transistor having a gate and said conduction path, and said discharge circuit means comprises:

gate voltage control means for providing a variable gate voltage to said gate over said first fraction for operating said transistor conduction path in a generally linearly increasing conduction range and for providing a fixed gate voltage to said gate over said second fraction for operating said transistor in saturation to allow exponential discharge of said output capacitor charge voltage through said conduction path, thereby providing said pacing pulse output voltage with an increasing voltage over said initial fraction and an exponentially decreasing voltage over said remaining fraction of said pacing pulse interval.

21. The pacing output pulse circuit of claim 20, wherein said gate voltage control means further comprises:

a diode circuit coupled to said gate for applying a fixed gate voltage to said gate for initially rendering said transistor conductive in said linear operating region and providing said initial pacing pulse voltage level in response to said trigger pulse; and

a capacitive charging circuit coupled with said diode circuit and said gate and responsive to said trigger pulse for providing an increasing gate voltage as said variable control signal over said first fraction of said pacing pulse interval until said capacitive charging circuit is charged to a saturation gate voltage level, whereby said transistor is conductive in saturation.

22. In a tissue stimulator having a timing means for timing a pulse interval and pulse generator means for providing a tissue stimulation pulse, the improvement comprising a pulse generator means configured for providing said tissue stimulation pulse such that when provided, said stimulation pulse has a voltage pulse waveform commencing at an initial pulse voltage level greater, in absolute value, than zero and increasing over an initial fraction of said pulse interval to an intermediate pulse voltage level and immediately thereafter exponentially decreasing in voltage amplitude from the intermediate pulse voltage level during a remaining fraction of said pulse interval.

23. The tissue stimulator of claim 22 wherein said voltage pulse waveform has a terminal end point following said remaining fraction characterized by having a terminal pulse voltage level greater, in absolute value, than zero.

24. In an implantable cardiac pacemaker having timing means for timing a pulse interval and pulse generator means for providing a pacing pulse, the improvement in said pulse generator means comprising circuit means for providing as said pacing pulse a voltage pulse waveform commencing at an initial pulse voltage level greater, in absolute value, than zero and increasing over an initial fraction of said pulse interval to an intermediate pulse voltage level and thereafter exponentially decreasing in voltage amplitude during a remaining faction of said pulse interval.

25. The pacemaker of claim 24 wherein said voltage pulse waveform has a terminal end point following said remaining fraction characterized by having a terminal pulse voltage level greater, in absolute value, than zero.