Hydrophilic, swellable coatings for biosensors
First Claim
1. A method of reducing electrode impedance of an implantable biosensor comprising coating said biosensor with a hydrogel, wherein said hydrogel is formed from a reaction mixture of:
- (a) a diisocyanate, said diisocyanate comprising about 50 mol % of the reactants in said mixture;
(b) a hydrophilic polymer which is a member selected from the group consisting of a hydrophilic polymer diol, a hydrophilic polymer diamine and combinations thereof; and
optionally;
(c) a chain extender, said hydrogel having a water pickup of from about 120% to about 400% by weight.
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Accused Products
Abstract
Methods for reducing the electrode impedance of implantable biosensors by coating the surface of the biosensor with a uniform hydrogel which allows unimpeded water movement around the sensor are provided. The surface coatings are compositions which are biocompatible and are capable of water uptake of at least 120% of their weight, more preferably at least 200% of their weight. Upon the uptake of water, the hydrogels used in the present invention will also swell and provide a layer of water around the electrodes to which the hydrogels are attached. The hydrogels can be prepared from (a) a diisocyanate, (b) a hydrophilic polymer which is a hydrophilic diol, a hydrophilic diamine, or a combination thereof, and optionally, (c) a chain extender.
436 Citations
15 Claims
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1. A method of reducing electrode impedance of an implantable biosensor comprising coating said biosensor with a hydrogel, wherein said hydrogel is formed from a reaction mixture of:
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(a) a diisocyanate, said diisocyanate comprising about 50 mol % of the reactants in said mixture; (b) a hydrophilic polymer which is a member selected from the group consisting of a hydrophilic polymer diol, a hydrophilic polymer diamine and combinations thereof; and
optionally;(c) a chain extender, said hydrogel having a water pickup of from about 120% to about 400% by weight. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8)
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9. An implantable biosensor having a hydrogel coating, said coating prepared from a reaction mixture of:
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(a) a diisocyanate, said diisocyanate comprising about 50 mol % of the reactants in said mixture; (b) a hydrophilic polymer which is a member selected from the group consisting of a hydrophilic polymer diol, a hydrophilic polymer diamine and combinations thereof; and
optionally;(c) a chain extender;
wherein said coating has a water pickup of from about 120% to about 400% by weight. - View Dependent Claims (10, 11, 12, 13, 14, 15)
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Specification