Method of preparing a forskohlin composition from forskohlin extract and use of forskohlin for promoting lean body mass and treating mood disorders

• US 5,804,596 A
• Filed: 02/27/1997
• Issued: 09/08/1998
• Est. Priority Date: 02/27/1997
• Status: Expired due to Term

• Current Assignee: Sami Labs Limited
• Original Assignee: Sabinsa Corporation (Sami-Sabinsa Group Limited)
• Inventors: Rajendran, R., Badmaey, Viadimir, Majeed, Muhammed
• Primary Examiner(s): Goldberg, Jerome D.
• Application Number:
  US08/807,652
• Time in Patent Office: 558 Days
• Field of Search: 514/455
• US Class Current: 514/455
• CPC Class Codes: A61K 31/352 condensed with carbocyclic rings, e.g. methantheline cannabinoids A61K31/658
• CPC Class Codes: A61P 3/04 Anorexiants; Antiobesity agents
• CPC Class Codes: A61P 43/00 Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Abstract

A method of promoting lean body mass in an individual is disclosed, comprising administering to the individual a lean body mass promoting effective amount of forskohlin. A method of treating a mood disorder is also disclosed, comprising administering to a patient in need thereof a mood disorder treating effective amount of forskohlin. Compositions suitable for promoting lean body mass and/or treating a mood disorder are also disclosed, the composition comprising about 1 to about 40% forskohlin in combination with at least one physiologically acceptable carrier or excipient. A method of preparing a forskohlin composition from a forskohlin extract of Coleus Forskoli plant is further disclosed, as well as a forskohlin composition prepared by the method.

Claims

1. A method of promoting lean body mass in a human individual in need thereof, comprising administering to the individual a lean body mass promoting effective amount of forskohlin.

2. The method of claim 1, wherein the forskohlin is administered in a daily dose of about 10 to about 60 mg.

3. The method of claim 2, wherein the daily dose is divided into a plurality of individual doses.

4. The method of claim 1, wherein the forskohlin is administered in an individual dose of about 10 to about 20 mg.

5. A method of shifting the proportion between lean body mass and adipose tissue in favor of lean body mass in a human individual in need thereof, comprising administering to the individual a proportion shifting effective amount of forskohlin.

6. The method of claim 5, wherein the forskohlin is administered in a daily dose of about 10 to about 60 mg.

7. The method of claim 6, wherein the daily dose is divided into a plurality of individual doses.

8. The method of claim 5, wherein the forskohlin is administered in an individual dose of about 10 to about 20 mg.