Medical noninvasive operations using focused modulated high power ultrasound

• US 5,827,204 A
• Filed: 05/27/1997
• Issued: 10/27/1998
• Est. Priority Date: 11/26/1996
• Status: Expired due to Fees

• Current Assignee: Willem Grandia, Yoseph Bar-Cohen
• Original Assignee: Willem Grandia, Yoseph Bar-Cohen
• Inventors: Bar-Cohen, Yoseph, Grandia, Willem
• Primary Examiner(s): Smith, Ruth S.
• Application Number:
  US08/863,162
• Time in Patent Office: 518 Days
• Field of Search: 601/2-4, 600/439, 600/427
• US Class Current: 601/2
• CPC Class Codes: A61B 17/2256 with means for locating or checking the concrement, e.g. X-ray apparatus, imaging means A61B17/2255 takes precedence
• CPC Class Codes: A61B 2017/22008 used or promoted
• CPC Class Codes: A61B 2017/22089 Gas-bubbles
• CPC Class Codes: A61B 2090/378 using ultrasound
• CPC Class Codes: A61N 2007/0039 using microbubbles
• CPC Class Codes: A61N 7/02 Localised ultrasound hyperthermia hyperthermia in general A61F7/00

Abstract

Medical noninvasive operations using focused modulated high power ultrasound in accordance with the present invention generally includes a transmitter for exciting a multifrequency ultrasound wave for causing vaporous cavitation bubbles in a small focal zone of a medical target region. Focused ultrasound can be used for both dissolving tissues as well as causing clots in order to destroy cancerous growths. The multifrequency wave includes an underlying low frequency signal for enabling optimal growth of microbubbles and at least one high frequency signal for enabling a narrow zone of focus of the ultrasound. A cavitation monitor may be provided for sensing a level of cavitation as well as providing feedback to the transmitter. In addition, an imaging system is provided for enabling viewing of the medical target area during the therapy.

Claims

1. Noninvasive surgical apparatus for affecting a medical target in a living being by destruction of undesired tissue or coagulation of blood, said apparatus comprising:

low frequency ultrasound means, including a low frequency ultrasound signal, for controlling growth of cavitation microbubbles in a medical target region, said low frequency ultrasound signal having an amplitude below a cavitation threshold of the target region,

means for superimposing at least one high frequency ultrasound signal onto the low frequency signal in order to produce a modulated ultrasound signal having an amplitude that exceeds said cavitation threshold, said modulated signal having a focal zone of a size determined by the high frequency signal; and

means for positioning the focal zone of the modulated signal into the medical target region in order to cause vaporous cavitation therein.

2. The noninvasive surgical apparatus according to claim 1 wherein the low frequency signal has a frequency of less than about 100 kHz.

3. The noninvasive surgical apparatus according to claim 2 wherein the high frequency signal has a frequency of between about 200 kHz and about 2.5 MHZ.

4. The noninvasive surgical apparatus according to claim 1 wherein the low frequency signal has a frequency of about 25 kHz.

5. The noninvasive surgical apparatus according to claim 4 wherein the high frequency signal has a frequency of between about 200 kHz and about 2.5 MHz.

6. The noninvasive surgical apparatus according to claim 1 further comprising hydrophone means for monitoring a formation of the vaporous cavitation in the target region.

7. The noninvasive surgical apparatus according to claim 6 further comprising imaging means for producing a visual image of the medical target region in order to enable observation of the region during destruction of unwanted tissue or coagulation of blood therein.

8. The noninvasive surgical apparatus according to claim 1 wherein the means for positioning includes a piezoelectric actuator.

9. Noninvasive surgical apparatus comprising an ultrasound transmitter, including:

a source of a high frequency ultrasound signal,

a source of a low frequency ultrasound signal, said low frequency ultrasound signal having an amplitude below a cavitation threshold of a medical target region in order to enhance bubble growth during vaporous cavitation and

means for superimposing the high frequency signal and the low frequency signal in order to produce a modulated, multifrequency signal; and

means for focusing the multifrequency signal into the medical target region in order to produce vaporous cavitation therein.

10. The noninvasive surgical apparatus according to claim 9 wherein the low frequency signal has a frequency of less than about 100 kHz.

11. The noninvasive surgical apparatus according to claim 10 wherein the high frequency signal has a frequency of between about 200 kHz and about 2.5 MHz.

12. The noninvasive surgical apparatus according to claim 9 wherein the low frequency signal has a frequency of about 25 kHz.

13. The noninvasive surgical apparatus according to claim 12 wherein the high frequency signal has a frequency of between about 200 kHz and about 2.5 MHz.

14. The noninvasive surgical apparatus according to claim 9 wherein further comprising hydrophone means for monitoring a formation of the vaporous cavitation in the medical target region.

15. The noninvasive surgical apparatus according to claim 14 further comprising imaging means for producing a visual image of the medical target area in order to enable observation of the medical target area during destruction of unwanted tissue or coagulation of blood therein.

16. A method for performing noninvasive surgery using modulated high powered ultrasound, said method comprising the steps of:

inducing a low frequency ultrasound signal at an amplitude below a cavitation threshold of a medical target region in order to control growth of cavitation microbubbles in the target region;

superimposing a high frequency signal onto the low frequency signal in order to produce a modulated signal having an amplitude that exceeds said cavitation threshold, said modulated signal having a focal zone of a size determined by the high frequency signal; and

positioning the focal zone of the modulated signal into the medical target region in order to cause vaporous cavitation therein.

17. The method according to claim 16 wherein the step of inducing a low frequency signal comprises inducing a low frequency signal of less than about 100 kHz.

18. The method according to claim 17 wherein the step of inducing a low frequency signal comprises inducing a low frequency signal of less than about 25 kHz.

19. The method according to claim 16 wherein the step of inducing a high frequency signal comprises the step of inducing a ultrasound signal of between about 200 kHz and about 2.5 MHZ.

20. The method according to claim 17 further comprising the steps of

monitoring the vaporous cavitation during the step of positioning the focal zone into the medical target and,

producing a visual image of the medical target region in order to enable observation of the region.