External preparation for application to the skin containing lidocaine

  • US 5,827,529 A
  • Filed: 06/10/1994
  • Issued: 10/27/1998
  • Est. Priority Date: 03/30/1991
  • Status: Expired due to Term
First Claim
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1. An external preparation for application to the skin containing lidocaine which comprises a drug-retaining layer placed on a support, wherein said drug-retaining layer comprises an adhesive gel base and 1 to 10% by weight of lidocaine, said base consisting essentially of 0.5 to 50% by weight of a water-soluble high molecular weight substance selected from the group consisting of gelatin, starch, agar, mannan, alginic acid, polyacrylic acid, a salt of polyacrylic acid, dextrin, methylcellulose, methylcellulose sodium, carboxymethylcellulose, carboxymethylcellulose sodium, polyvinyl alcohol, polyvinyl pyrrolidone, copolymer of methyl vinyl ether and maleic anhydride, gum arabic, tragacanth, karaya gum and locust bean gum, 30 to 70% by weight of water and 1 to 70% by weight of a water-retaining agent selected from the group consisting of ethylene glycol, diethylene glycol, polyethylene glycol, glycerin, sorbitol, martitol, propylene glycol and 1,3-butylene glycol, said lidocaine being dissolved in the base so as to result in a uniform base material.

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