Apparatus and method for measuring an induced perturbation to determine a physical condition of the human arterial system

• US 5,830,131 A
• Filed: 11/22/1995
• Issued: 11/03/1998
• Est. Priority Date: 04/15/1994
• Status: Expired due to Term

• Current Assignee: Masimo Corporation
• Original Assignee: Vital Insite, Inc.
• Inventors: Caro, Richard G., Sher, Mark H., Flaherty, Bryan P.
• Primary Examiner(s): Nasser, Robert L.
• Application Number:
  US08/561,928
• Time in Patent Office: 1,077 Days
• Field of Search: 126/603, 126/633, 126/630, 126/664-8, 126/672-694, 126/696, 126/713, 126/716, 126/719, 126/721, 126/722, 126/735, 126/748, 126/774
• US Class Current: 600/300
• CPC Class Codes: A61B 5/02108 from analysis of pulse wave characteristics
• CPC Class Codes: A61B 5/02133 by using induced vibration of the blood vessel
• CPC Class Codes: A61B 5/022 by applying pressure to close blood vessels, e.g. against the skin; Ophthalmodynamometers

Abstract

A monitor for determining a patient'"'"'s physical condition includes a calibration device configured to provide a calibration signal representative of a patient'"'"'s physiological parameter. An exciter is positioned over a blood vessel of the patient for inducing a transmitted exciter waveform into the patient. A noninvasive sensor is positioned over the blood vessel, where the noninvasive sensor is configured to sense a hemoparameter and to generate a noninvasive sensor signal representative of the hemoparameter containing a component of a physiological parameter waveform and a component of a received exciter waveform. In this context, a hemoparameter is defined as any physiological parameter related to vessel blood such as pressure, flow, volume, velocity, blood vessel wall motion, blood vessel wall position and other related parameters. A processor is configured to determine a relationship between a property of the received exciter waveform and a property of the physiological parameter. The processor is connected to receive the calibration signal and the noninvasive sensor signal, and the processor is configured to process the calibration signal and the noninvasive sensor signal to determine the physical condition. In an exemplary embodiment, the physical condition is arterial stiffness that represents cardiovascular disease, however, many additional physical conditions can be measured and determined such as arterial elasticity, arterial thickness, arterial wall compliance and other conditions. Also, in an exemplary embodiment, the physiological parameter measured is blood pressure, however, the present invention can also be used to analyze and track other physiological parameters

Claims

1. A monitor for use in determining a patient'"'"'s physical condition, comprising:

an exciter adapted to be positioned over a blood vessel of the patient and configured to induce a transmitted exciter waveform into the patient;

a noninvasive sensor spaced apart from said exciter, adapted to be positioned over said blood vessel and configured to sense a hemoparameter and to generate a noninvasive sensor signal representative of said hemoparameter containing a component of a received exciter waveform; and

a processor coupled to said noninvasive sensor and configured to receive said noninvasive sensor signal and to process said noninvasive sensor signal to determine a physical property of the patient in order to provide a condition signal related to said physical condition.

2. The monitor of claim 1, further comprising:

a device configured to provide a pressure signal representative of a blood pressure of the patient; and

wherein said processor is configured to receive said pressure signal and to provide said pressure signal as an output.

3. The monitor of claim 2, wherein:

said processor is configured to compare said condition signal to a previously stored condition signal to provide a relative condition signal related to said physical condition.

4. The monitor of claim 1, further comprising:

a device configured to provide a pressure signal representative of a blood pressure of the patient; and

wherein said processor is configured to receive said pressure signal and to process said pressure signal to provide said condition signal.

5. The monitor of claim 4, wherein:

said processor is configured to compare said condition signal to a previously stored condition signal to provide a relative condition signal related to said physical condition.

6. The monitor of claim 4, wherein:

said processor is configured to determine a propagation parameter of said received exciter waveform and to process said propagation parameter and said pressure signal to provide said condition signal.

7. The monitor of claim 6, wherein:

said processor is configured to determine a relationship between said propagation parameter and said pressure signal; and

said processor is configured to provide said condition signal based at least in part on said relationship.

8. The monitor of claim 4, wherein:

said processor is configured to determine a derivative of a propagation parameter of said received exciter waveform and to process said derivative and said pressure signal to provide said condition signal.

9. The monitor of claim 8, wherein:

said processor is configured to compare said condition signal to a previously stored condition signal provide a relative condition signal related to said physical condition.

10. The monitor of claim 4, wherein:

said physical condition is a mechanical property of said blood vessel; and

said processor is configured to process said noninvasive sensor signal and said pressure signal to provide said condition signal related to said mechanical property.

11. The monitor of claim 10, wherein:

said processor is configured to compare said condition signal to a previously stored condition signal provide a relative condition signal related to said physical condition.

12. The monitor of claim 1, wherein:

said processor is configured to compare said condition signal to a previously stored condition signal to provide a relative condition signal related to said physical condition.

13. The monitor of claim 1, wherein:

said processor is configured to determine a propagation parameter of said received exciter waveform and to process said propagation parameter to provide said condition signal.

14. The monitor of claim 1, wherein:

said processor is configured to store a relationship between a propagation parameter and a blood pressure; and

said processor is configured to provide said condition signal based at least in part on said relationship.

15. The monitor of claim 1, wherein:

said processor is configured to determine a derivative of a propagation parameter of said received exciter waveform and to process said derivative to provide said condition signal.

16. The monitor of claim 15, wherein:

said processor is, configured to compare said condition signal to a previously stored condition signal provide a relative condition signal related to said physical condition.

17. The monitor of claim 1, wherein:

said physical condition is a mechanical property of said blood vessel; and

said processor is configured to process said noninvasive sensor signal to provide said condition signal related to said mechanical property.

18. The monitor of claim 17, wherein:

said processor is configured to compare said condition signal to a previously stored condition signal provide a relative condition signal related to said physical condition.

19. A processor for use in determining a patient'"'"'s physical condition with an apparatus having an exciter positioned over a blood vessel of the patient and configured to induce a transmitted exciter waveform into the patient, and a noninvasive sensor spaced apart from said exciter and adapted to be positioned over said blood vessel and configured to sense a hemoparameter and to generate a noninvasive sensor signal representative of said hemoparameter, said processor comprising:

a first input configured to receive said noninvasive sensor signal; and

a determination routine configured to process said noninvasive sensor signal to determine a physical property of the patient in order to provide a condition signal related to said physical condition.

20. The processor of claim 19, wherein said apparatus includes a device configured to provide a pressure signal representative of a blood pressure of the patient, said processor further comprising:

a second input configured to receive said pressure signal; and

an output pressure routine configured to provide said pressure signal as an output.

21. The processor of claim 20, further comprising:

a comparison routine configured to compare said condition signal to a previously stored condition signal to provide a relative condition signal related to said physical condition.

22. The processor of claim 19, wherein said apparatus includes a device configured to provide a pressure signal representative of a blood pressure of the patient, said processor further comprising:

a second input configured to receive said pressure signal; and

wherein said determination routine is configured to process said pressure signal to provide said condition signal.

23. The processor of claim 22, further comprising:

a comparison routine configured to compare said condition signal to a previously stored condition signal to provide a relative condition signal related to said physical condition.

24. The processor of claim 22, further comprising:

a propagation routine configured to determine a propagation parameter of said received exciter waveform; and

wherein said determination routine is configured to process said propagation parameter and said pressure signal to provide said condition signal.

25. The processor of claim 24, further comprising:

a relationship routine configured to determine a relationship between a propagation parameter and blood pressure; and

wherein said determination routine is configured to provide said condition signal based at least in part on said relationship.

26. The processor of claim 22, further comprising:

a derivative routine configured to determine a derivative of a propagation parameter of said received exciter waveform; and

wherein said determination routine is configured to process said derivative and said pressure signal to provide said condition signal.

27. The processor of claim 26, further comprising:

a comparison routine configured to compare said condition signal to a previously stored condition signal to provide a relative condition signal related to said physical condition.

28. The monitor of claim 22, wherein:

said physical condition is a mechanical property of said blood vessel; and

said determination routine is configured to process said pressure signal to provide said condition signal related to said mechanical property.

29. The monitor of claim 28, further comprising:

a comparison routine configured to compare said condition signal to a previously stored condition signal to provide a relative condition signal related to said physical condition.

30. The processor of claim 19, further comprising:

a comparison routine configured to compare said condition signal to a previously stored condition signal to provide a relative condition signal related to said physical condition.

31. The processor of claim 19, further comprising:

a propagation routine configured to determine a propagation parameter of said received exciter waveform; and

wherein said determination routine is configured to process said propagation parameter to provide said condition signal.

32. The processor of claim 19, further comprising:

a memory configured to store a relationship between a propagation parameter and blood pressure; and

wherein said determination routine is configured to provide said condition signal based at least in part on said relationship.

33. The processor of claim 19, further comprising:

a derivative routine configured to determine a derivative of a propagation parameter of said received exciter waveform; and

wherein said determination routine is configured to process said derivative to provide said condition signal.

34. The processor of claim 33, further comprising:

a comparison routine configured to compare said condition signal to a previously stored condition signal to provide a relative condition signal related to said physical condition.

35. The processor of claim 19, wherein:

said physical condition is a mechanical property of said blood vessel; and

said determination routine is configured to provide said condition signal related to said mechanical property.

36. The monitor of claim 35, further comprising:

a comparison routine configured to compare said condition signal to a previously stored condition signal to provide a relative condition signal related to said physical condition.

37. A method for use in determining a patient'"'"'s physical condition, comprising the steps of:

inducing a transmitted exciter waveform into the patient at a first location;

noninvasively sensing a hemoparameter at a location spaced apart from said first location and generating a noninvasive sensor signal representative of said hemoparameter containing a component of a received exciter waveform;

processing said noninvasive sensor signal to determine a physical property of the patient in order to provide a condition signal related to said physical condition.

38. The method of claim 37, further comprising the step of:

providing a calibration signal representative of the patient'"'"'s physiological parameter and storing the calibration signal; and

wherein said processing step includes a step of providing said pressure signal as an output.

39. The method of claim 38, further comprising the step of:

comparing said condition signal to a previously stored condition signal to provide a relative condition signal related to said physical condition.

40. The method of claim 37, further comprising the step of:

providing a calibration signal representative of the patient'"'"'s physiological parameter and storing the calibration signal; and

wherein said processing step is performed by processing said pressure signal to provide said condition signal.

41. The method of claim 40, further comprising the step of:

comparing said condition signal to a previously stored condition signal to provide a relative condition signal related to said physical condition.

42. The method of claim 39, further comprising the step of:

determining a propagation parameter of said received exciter waveform; and

wherein said processing step is performed by processing said propagation parameter and said pressure signal to provide said condition signal.

43. The method of claim 42, further comprising the step of:

determining a relationship between said propagation parameter and said pressure signal; and

wherein said processing step is performed to provide said condition signal based at least in part on said relationship.

44. The method of claim 39, further comprising the step of:

determining a derivative of a propagation parameter of said received exciter waveform; and

wherein said processing step is performed by processing said derivative and said pressure signal to provide said condition signal.

45. The method of claim 44, further comprising the step of:

comparing said condition signal to a previously stored condition signal to provide a relative condition signal related to said physical condition.

46. The method of claim 39, wherein:

said physical condition is a mechanical property of said blood vessel; and

said processing step is performed to process said noninvasive sensor signal and said pressure signal to provide said condition signal related to said mechanical property.

47. The method of claim 46, further comprising the step of:

comparing said condition signal to a previously stored condition signal to provide a relative condition signal related to said physical condition.

48. The method of claim 37, further comprising the step of:

comparing said condition signal to a previously stored condition signal to provide a relative condition signal related to said physical condition.

49. The method of claim 37, further comprising the step of:

determining a propagation parameter of said received exciter waveform; and

wherein said processing step is performed by processing said propagation parameter to provide said condition signal.

50. The method of claim 37, further comprising the step of:

storing a relationship between a propagation parameter and a blood pressure; and

wherein said processing step is performed to provide said condition signal based at least in part on said relationship.

51. The method of claim 37, further comprising the step of:

determining a derivative of a propagation parameter of said received exciter waveform; and

wherein said processing step is performed by processing said derivative to provide said condition signal.

52. The method of claim 51, further comprising the step of:

comparing said condition signal to a previously stored condition signal to provide a relative condition signal related to said physical condition.

53. The method of claim 37, wherein:

said physical condition is a mechanical property of said blood vessel; and

said processing step is performed to process said noninvasive sensor signal to provide said condition signal related to said mechanical property.

54. The method of claim 53, further comprising the step of:

comparing said condition signal to a previously stored condition signal to provide a relative condition signal related to said physical condition.

55. A monitor for use in determining a patient'"'"'s physical condition, comprising:

a device configured to provide a pressure signal representative of a blood pressure of the patient;

an exciter adapted to be positioned over a blood vessel of the patient and configured to induce a transmitted exciter waveform into the patient;

a noninvasive sensor spaced apart from said exciter and adapted to be positioned over said blood vessel from said exciter and configured to sense a hemoparameter and to generate a noninvasive sensor signal representative of said hemoparameter containing a component of a received exciter waveform; and

a processor coupled to said noninvasive sensor and configured to receive said noninvasive sensor signal and said pressure signal and to process said noninvasive sensor signal and said pressure signal to determine a physical property of the patient in order to provide a condition signal related to said physical condition.

56. The monitor of claim 55, wherein:

said processor is configured to determine a velocity of said transmitted exciter waveform and to process said velocity to provide said condition signal.

57. The monitor of claim 56, wherein:

said processor is configured to determine a relationship between the velocity of said transmitted exciter waveform and said pressure signal; and

said processor is configured to provide said condition signal based at least in part on said relationship.