Apparatus and method for optimizing cardiac performance by determining the optimal timing interval from an accelerometer signal

• US 5,836,987 A
• Filed: 03/12/1997
• Issued: 11/17/1998
• Est. Priority Date: 11/15/1995
• Status: Expired due to Term

• Current Assignee: Cardiac Pacemakers Incorporated (Boston Scientific Corporation)
• Original Assignee: Cardiac Pacemakers Incorporated (Boston Scientific Corporation)
• Inventors: Silvermint, Emanuel H., Tockman, Bruce A., Salo, Rodney W., Baumann, Lawrence S.
• Primary Examiner(s): Kamm, William E.
• Assistant Examiner(s): EVANISKO, GEORGE ROBERT
• Application Number:
  US08/815,697
• Time in Patent Office: 615 Days
• Field of Search: 607/17, 607/18, 607/24, 607/25
• US Class Current: 607/17
• CPC Class Codes: A61N 1/3627 for treating a mechanical deficiency of the heart, e.g. congestive heart failure or cardiomyopathy
• CPC Class Codes: A61N 1/36542 controlled by body motion, e.g. acceleration
• CPC Class Codes: A61N 1/3682 with a variable atrioventricular delay

Abstract

A cardiac stimulating apparatus and method which optimizes cardiac performance by determining, from a filtered waveform transmitted from an accelerometer contained within the cardiac pacer, an optimum timing interval between at least one of intrinsic and paced stimulations of pre-selected chambers of the heart. Digitized data of the accelerometer signal, corresponding with identified R--R intervals, are stored for a plurality of preselected timing intervals for analysis and comparison. The accelerometer signal is filtered to isolate features of the waveform associated with specific cardiac events including for example, the first heart sound, the second heart sound or an amplitude in the frequency domain thereof. Characteristic values of these features of the accelerometer signal are calculated over a plurality of complete R--R intervals for each of the preselected timing intervals. The characteristic values are analyzed and compared to determine which timing interval optimizes cardiac performance. The cardiac stimulating apparatus and method may be used in any of several pacing modes including A-V pacing, V--V pacing, or A--A pacing.

Claims

1. A cardiac stimulating apparatus functioning in a preset pacing mode, and programmed to optimize cardiac performance of a patient'"'"'s heart, comprising:

a) a dual chamber cardiac pacer and leads coupled to said cardiac pacer for sensing atrial and ventricular events of a patient'"'"'s heart and for stimulating preselected chambers of the heart, and further including a cardiac cycle means for identifying cardiac cycles of the patient'"'"'s heart;

b) a cardiac electrogram coupled to said cardiac pacer for identifying R--R intervals of the patient'"'"'s heart;

c) an accelerometer contained within a housing of said cardiac pacer and coupled to a microprocessor based controller of said cardiac pacer, said accelerometer having a filter wherein said accelerometer transmits to the cardiac pacer a waveform having various features associated with mechanical movement events within an atrium and mechanical movement events within a ventricle; and

d) said microprocessor based controller including feature means for identifying pre-selected features of the waveform transmitted by the accelerometer, means for corresponding the R--R interval identified by the cardiac electrogram with the features identified by the feature means, and analyzing means for analyzing identified features over corresponding R--R intervals, wherein the identified features are analyzed and compared by said microprocessor over a preselected number of R--R intervals for a plurality of preselected timing intervals, said timing intervals being a time between at least one of intrinsic and paced stimulations of pre-selected chambers of the heart, to thereby determine an optimum timing interval.

2. The cardiac stimulating apparatus as recited in claim 1 wherein said pre-selected features are selected from the group consisting of an amplitude in the frequency domain of the waveform, an amplitude associated with a first heart sound and an amplitude associated with a second heart sound.

3. The cardiac stimulating apparatus as recited in claim 1, wherein said microprocessor-based controller analyzes and compares characteristic values of the identified features over the plurality of pre-selected timing intervals.

4. The cardiac stimulating apparatus as recited in claim 1, wherein said microprocessor-based controller includes a means for identifying, from the waveform transmitted by the accelerometer, a time of physical inactivity.

5. The cardiac stimulating apparatus as recited in claim 1, further including a respiratory means for identifying complete respiratory cycles and means for corresponding identified respiratory cycles with the features identified by the feature means, whereby the identified features are analyzed and compared over a plurality respiratory cycles.

6. The cardiac stimulating apparatus as recited in claim 1, wherein the dual chamber cardiac pacer functions in a pacing mode selected from the group consisting of A-V pacing, V--V pacing and A--A pacing.

7. The cardiac stimulating apparatus as recited in claim 6, wherein the A-V pacing mode is selected from the group consisting of A_R -V_R pacing, A_R -V_L pacing, A_L -V_R pacing, A_R - V_RL pacing, A_L -V_RL pacing, and A_L -V_L pacing.

8. A cardiac stimulating apparatus functioning in a rate adaptive preset pacing mode, and programmed to optimize cardiac performance of a patient'"'"'s heart, comprising:

a) a dual chamber cardiac pacer and leads coupled to said cardiac pacer for sensing atrial and ventricular events of a patient'"'"'s heart and for stimulating preselected chambers of the heart, and further including a cardiac cycle means for identifying cardiac cycles of the patient'"'"'s heart;

b) a cardiac electrogram coupled to said cardiac pacer for identifying R--R intervals of the patient'"'"'s heart;

c) an accelerometer contained within a housing of said cardiac pacer and coupled to a microprocessor based controller of said cardiac pacer, said accelerometer having a filter wherein said accelerometer transmits to the cardiac pacer a waveform having various features associated with mechanical movement events within an atrium and mechanical movement events within a ventricle; and

d) said microprocessor based controller including feature means for identifying pre-selected features of the waveform transmitted by the accelerometer, respiratory means coupled to said cardiac pacer for identifying complete respiratory cycles, means for corresponding both the R--R interval identified by the cardiac electrogram and the respiratory cycles identified by the respiratory means with the features identified by the feature means, and analyzing means for analyzing identified features over corresponding R--R intervals and respiratory cycles, wherein the identified features are analyzed and compared by said microprocessor over a preselected number of at least one of R--R intervals and respiratory cycles for a plurality of preselected timing intervals, said timing intervals being a time between at least one of intrinsic and paced stimulations of pre-selected chambers of the heart, to thereby determine an optimum timing interval.

9. The cardiac stimulating apparatus as recited in claim 8, wherein said pre-selected features are selected from the group consisting of an amplitude in the frequency domain of the waveform, an amplitude associated with a first heart sound and an amplitude associated with a second heart sound.

10. The cardiac stimulating apparatus as recited in claim 8, wherein said microprocessor-based controller analyzes and compares characteristic values of the identified features over the plurality of pre-selected timing intervals.

11. The cardiac stimulating apparatus as recited in claim 8, wherein said microprocessor-based controller includes a means for identifying, from the waveform transmitted by the accelerometer, a time of physical inactivity.

12. The cardiac stimulating apparatus as recited in claim 8, wherein the dual chamber cardiac pacer functions in a pacing mode selected from the group consisting of A-V pacing, V--V pacing and A--A pacing.

13. The cardiac stimulating apparatus as recited in claim 12, wherein the A-V pacing mode is selected from the group consisting of A_R -V_R pacing, A_R -V_L pacing, A_L -V_R pacing, A_R -V_RL pacing, A_L -V_RL pacing, and A_L -V_L pacing.

14. A method for optimizing the timing interval of an implantable cardiac pacer between intrinsic and paced stimulations of pre-selected chambers of a patient'"'"'s heart, said pacer being of the type having a microprocessor-based controller having memory, a pulse generator, and an accelerometer for sensing mechanical atrial and ventricular events contained therein, said method comprising the steps of:

a) pacing a patient'"'"'s heart with the implantable cardiac pacer, wherein the cardiac pacer has a preset pacing mode, identifies cardiac cycles of the patient'"'"'s heart and controls a timing interval between at least one of intrinsic and paced stimulations of preselected chambers of the heart;

b) setting the timing interval of the implantable cardiac pacer to a first value of a predetermined set of timing interval values;

c) receiving a signal from the accelerometer;

d) coupling a cardiac electrogram to the implantable cardiac pacer to identify R--R intervals of the patient'"'"'s heart;

e) identifying pre-selected features from the signal, and storing data associated with identified features of the signal received from the accelerometer for a plurality of R--R intervals in the memory of the microprocessor-based controller;

f) calculating from the identified features, characteristic values of the identified features of the signal;

g) selecting a new timing interval value from the predetermined set of timing interval values;

h) repeating steps c-g until all the timing interval values of the predetermined set of timing interval values have been used;

i) analyzing and comparing the calculated characteristic values for each timing interval value of the predetermined set of timing interval values, to determine an optimum timing interval value; and

j) setting the timing interval of the implantable cardiac pacer to the determined optimum timing interval value.

15. The method as in claim 14, and further including, before step b), the further step of inhibiting the steps of b)-j) if a level of physical activity of the patient determined from the signal received from the accelerometer is greater than a predetermined amount.

16. The method as in claim 14 and further including the step of waiting a predetermined amount of time between steps b) and c).

17. The method as in claim 14, further including the step of selecting a pacing mode of the implantable cardiac pacer from a group consisting of A-V pacing, V--V pacing and A--A pacing.

18. The method as recited in claim 17, further including the step of selecting the A-V pacing mode from the group consisting of A_R -V_R pacing, A_R -V_L pacing, A_L -V_R pacing, A_R -V_RL pacing, A_L -V_RL pacing, and A_L -V_L pacing.

19. The method as recited in claim 14, wherein the pre-selected features are selected from the group consisting of an amplitude in the frequency domain of the waveform, an amplitude associated with a first heart sound and an amplitude associated with a second heart sound.

20. The method as recited in claim 14, wherein the predetermined set of timing interval values comprise alternation between a baseline value and a randomly selected timing interval value.