Use of plant extracts for treatment of HIV, HCV and HBV infections

• US 5,837,257 A
• Filed: 05/27/1997
• Issued: 11/17/1998
• Est. Priority Date: 07/09/1996
• Status: Expired due to Term

• Current Assignee: Genic Biotech, Co., Ltd.
• Original Assignee: Sage R&D
• Inventors: Kung, Pai-Chu, Hwang, Shie-Ming, Tsai, Hsiu-Hsien
• Primary Examiner(s): Naff, David M.
• Assistant Examiner(s): Kerr, Janet M.
• Application Number:
  US08/863,803
• Time in Patent Office: 539 Days
• Field of Search: 424/195.1, 424/451, 424/464, 424/456, 424/489
• US Class Current: 424/741
• CPC Class Codes: A61K 2300/00 Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
• CPC Class Codes: A61K 36/00 Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines antigens from pollen A61K39/36
• CPC Class Codes: A61K 36/28 Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
• CPC Class Codes: A61K 36/48 Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
• CPC Class Codes: A61K 36/638 Ligustrum, e.g. Chinese privet
• CPC Class Codes: A61K 36/81 Solanaceae (Potato family), e.g. tobacco, nightshade, tomato, belladonna, capsicum or jimsonweed
• CPC Class Codes: A61K 9/20 Pills, tablets, discs, rods A61K9/0004, A61K9/0007, A61K9/0056, A61K9/0065 take precedence; for reconstitution of a drink A61K9/0095
• CPC Class Codes: A61K 9/48 Preparations in capsules, e.g. of gelatin, of chocolate A61K9/0004 takes precedence; bite capsules A61K9/0056
• CPC Class Codes: A61P 31/12 Antivirals
• CPC Class Codes: A61P 31/18 for HIV

Abstract

This invention relates to compositions derived from Chinese herbal medicines, medicinal plants and extracts thereof, and to their use for the treatment of animals infected with viruses, especially with hepatitis B virus (HBV), hepatitis C virus (HCV), and human immunodeficiency virus (HIV). More specifically, the compositions of the present invention are derived from various Chinese herbal medicines or medicinal plants which have a long history of human consumption. The compositions of the invention are obtained through specific techniques and have demonstrated outstanding efficacy for treating human HBV carriers and hepatitic C patients. Compositions according to the invention have also exhibited in vitro antiviral activities against murine leukemia virus (MuLV) and HIV. HIV is the virus known to cause acquired immunodeficiency syndrome (AIDS) in humans and AIDS presents special problems to the medical community which the present invention addresses.

Claims

1. A method for treating a subject having a viral infection selected from the group consisting of hepatitis B virus (HBV), hepatitis C virus (HCV), leukemia virus (LV) and human immunodeficiency virus (HIV), said method comprising administering to said subject in need thereof, a therapeutically effective amount of a composition which comprises at least one herbal medicine selected from the group consisting of:

a) SOLANI HERBA, prepared from the whole plant of Solanum nigrum;

b) LESPEDEZAE HERBA, prepared from the whole plant of Lespedeza cuneata;

c) SENECINIS HERBA, prepared from the whole plant of Senecio scandens; and

d) LIGUSTRI FRUCTUS, prepared from the mature fruit of at least one plant selected from the group consisting of Ligustrum lucidum and Ligustrum japonicum.

2. The method of claim 1 wherein said composition additionally comprises at least one herbal medicine selected from the group consisting of:

a) HEDYOTIS, prepared from the whole plant of Hedyotis diffusa;

b) SCUTELLARIAE BARBATAE HERBA, prepared from the whole plant of at least one selected from the group consisting of Scutellaria barbata, Scutellaria rivularis and Scutellaria dependens;

c) LONICERAE FLOS, prepared from the flower bud of at least one plant selected from the group consisting of Lonicera japonica and Lonicera confusa;

d) PRUNELLAE SPICA, prepared from the spica or whole plant of at least one plant selected from the group consisting of Prunella vulgaris and Prunella vulgaris subsp. asiatica;

e) BLECHNI RHIZOMA, prepared from at least one plant selected from the group consisting of Blechnum orientate, Osmunda japonica, Woodwardia orientalis, Woodwardia unigemmata, Athyrium acrostichoides, Sphaeropteris lepifera, Cyrtomium falcatum and Cyrtomium fortunei;

f) DRYOPTERIS CRASSIRHIZOMAE RHIZOMA, prepared from at least one plant selected from the group consisting of Dryopteris crassirhizoma, Osmunda japonica, Woodwardia orientalis, Woodwardia unigemmata, Athyrium acrostichoides, Sphaeropteris lepifera, Cyrtomium falcatum and Cyrtomium fortunei;

g) CIRSII RHIZOMA ET RADIX, prepared from the rhizome, root or whole plant of at least one plant selected from the group consisting of Cirsium japonicum, Cirsium albescens and Cirsium japonicum vat. australe;

h) BREEAE RADIX, prepared from the root of at least one plant selected from the group consisting of Breea segetum and Breea setosum;

i) AEGINETIAE HERBA, prepared from the whole plant of at least one plant selected from the group consisting of Aeginetia indica, Dichondra micrantha, Striga lutea and Dichondra repens;

j) BAPHICACANTHIS RHIZOMA ET RADIX, prepared from the rhizome or root of at least one plant selected from the group consisting of Baphicacanthes cusia, Strobilanthes cusia, Isatis tinctoria, Isatis indigotica and Polygonum tinctorium;

k) POLYGONI CUSPIDATI RHIZOMA, prepared from the rhizome of at least one plant selected from the group consisting of Polygonum cuspidatum, Polygonum runcinatum and Polygonum reynoutria;

l) FORSYTHIAE FRUCTUS, prepared from the mature fruit of at least one plant selected from the group consisting of Forsythia suspensa, Forsythia viridissima and Forsythia koreana;

m) PHELLODENDRI CORTEX, prepared from the cortex of at least one plant selected from the group consisting of Phellodendron amurense, Phellodendron chinense, Phellodendron amurense var. sachalinense and Phellodendron wilsonii; and

n) BLETILLAE TUBER, prepared from the tuber of Bletilla striata.

3. The method according to claim 2 wherein said composition comprises:

a) HEDYOTIS;

b) SCUTELLARIAE BARBATAE HERBA;

c) LONICERAE FLOS;

d) PRUNELLAE SPICA; and

e) SOLANI HERBA.

4. The method according to claim 3 wherein the weight ratio of a:

b;

c;

d;

e is about 3;

3;

3;

3;

4.

5. The method according to claim 2 wherein said composition comprises:

a) HEDYOTIS;

b) AEGINETIAE HERBA;

c) BAPHICACANTHIS RHIZOMA ET RADIX;

d) POLYGONI CUSPIDATI RHIZOMA;

e) FORSYTHIAE FRUCTUS;

f) PHELLODENDRI CORTEX

g) BLETILLAE TUBER; and

h) LIGUSTRI FRUCTUS.

6. The method of claim 2 wherein said composition comprises:

a) LONICERAE FLOS;

b) PRUNELLAE SPICA;

c) AEGINETIAE HERBA; and

d) at least one herbal medicine selected from the group consisting of LESPEDEZAE HERBA and SENECINIS HERBA.

8. The method of claims 2, 3, 5 or 6 wherein said composition is administered as a beverage, capsule, tablet, powder, candy, gel, nutritional product or pharmaceutical product.

7. The method of 2, 3, 5 or 6 wherein said therapeutically effective amount is 0.4 to 120 grams per day.

9. A method for treating a subject having a viral infection selected from the group consisting of HIV, LV, and HCV, said method comprising administering to said subject in need thereof, a therapeutically effective amount of a composition comprising at least one herbal medicine selected from the group consisting of:

a) HEDYOTIS, prepared from the whole plant of Hedyotis diffusa;

b) AEGINETIAE HERBA, prepared from the whole plant of at least one plant selected from the group consisting of Aeginetia indica, Dichondra micrantha, Striga lutea and Dichondra repens;

c) SCUTELLARIAE BARBATAE HERBA, prepared from the whole plant of at least one plant selected from the group consisting of Scutellaria barbata, Scutellaria rivularis and Scutellaria dependens; and

d) FORSYTHIAE FRUCTUS, prepared from the mature fruit of at least one plant selected from the group consisting of Forsythia suspensa, Forsythia viridissima and Forsythia koreana.

10. The method of claim 9 wherein said composition comprises:

a) AEGINETIAE HERBA; and

b) at least one herbal medicine selected from the group consisting of;

(i) SCUTELLARIAE BARBATAE HERBA;

(ii) HEDYOTIS;

(iii) FORSYTHIAE FRUCTUS;

(iv) LONICERAE FLOS, prepared from the flower bud of at least one plant selected from the group consisting of Lonicera japonica and Lonicera confusa;

(v) PRUNELLAE SPICA, prepared from the spica or whole plant of at least one plant selected from the group consisting of Prunella vulgaris and Prunella vulgaris subsp. asiatica;

(vi) POLYGONI CUSPIDATI RHIZOMA, prepared from the rhizome of at least one plant selected from the group consisting of Polygonum cuspidatum, Polygonum runcinatum and Polygonum reynoutria;

(vii) BLECHNI RHIZOMA, prepared from at least one plant selected from the group consisting of Blechnum orientale, Osmunda japonica, Woodwardia orientalis, Woodwardia unigemmata, Athyrium acrostichoides, Sphaeropteris lepifera, Cyrtomium falcatum and Cyrtomium fortunei; and

(viii) DRYOPTERIS CRASSIRHIZOMAE RHIZOMA, prepared from the plant Dryopteris crassirhizoma.

11. The method of claim 10 wherein said therapeutically effective amount is 0.4 to 120 grams per day.

12. The method of claim 10 wherein the weight ratio of a) to b) is from 1:

10 to 10;

1.

13. The method of claim 10 wherein said composition is administered as a beverage, capsule, tablet, powder, candy, gel, nutritional product or pharmaceutical product.