Enhancement of non-specific immune defenses by administration of underivatized, aqueous soluble glucans

CAFC
  • US 5,849,720 A
  • Filed: 03/08/1995
  • Issued: 12/15/1998
  • Est. Priority Date: 09/08/1989
  • Status: Expired due to Term
First Claim
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1. A method of treating an immunocompromised human or animal comprising administering to said human or animal an amount of an underivatized, aqueous soluble yeast β

  • (1-3) glucan sufficient to enhance the non-specific defenses of mononuclear cells or macrophages or both in said animal or human, wherein the underivatized, aqueous soluble yeast β

    (1-3) glucan is produced by a process comprising the steps of;

    a) contacting a suspension of aqueous insoluble β

    (1-3) glucan derived from yeast with an organic acid to solubilize said glucan thereby forming an acid-soluble and acid-insoluble glucan mixture;

    b) contacting the acid-soluble portion of the glucans with an alkali solution to dissolve the alkali-soluble glucan;

    c) removing alkali-insoluble glucans from the solution of step (b);

    d) neutralizing the solution containing the alkali-soluble glucan of step (c); and

    e) isolating an aqueous soluble β

    (1-3) glucan by size fractionation to produce a β

    (1-3) glucan that is suitable for parenteral administration,thereby treating said immunocompromised human or animal by enhancing the non-specific defenses of mononuclear cells or macrophages or both.

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